Subtypes include adenoid cystic carcinoma (ACCa), adenocarcinoma, squamous cell carcinoma, acinic cell carcinoma, carcinoma ex pleomorphic adenoma, and mucoepidermoid carcinoma
Definitions
Malignant epithelial neoplasm of lacrimal gland
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wang YZ et al: [Value of the apparent diffusion coefficient in diffusion weighted imaging at 3.0T MR for differentiating lacrimal gland tumors.] Zhonghua Yi Xue Za Zhi. 99(1):53-6, 2019
Gündüz AK et al: Overview of benign and malignant lacrimal gland tumors. Curr Opin Ophthalmol. 29(5):458-68, 2018
Young SM et al: Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences. Br J Ophthalmol.103(2):264-8, 2018
Lorenzano D et al: The "wedge sign": an imaging sign for aggressive lacrimal gland disease. Ophthalmology. 124(7):1081-3, 2017
Ableman TB et al: Perineural spread of head and neck cancer: Ophthalmic considerations. J Neurol Surg B Skull Base. 77(2):131-9, 2016
Sanders JC et al: Adenoid cystic carcinoma of the lacrimal gland. Am J Otolaryngol. 37(2):144-7, 2016
Woo KI et al: Current treatment of lacrimal gland carcinoma. Curr Opin Ophthalmol. 27(5):449-56, 2016
von Holstein SL et al: Tumors of the lacrimal gland. Semin Diagn Pathol. 33(3):156-63, 2016
Ahmad SM et al: American Joint Committee on Cancer classification predicts outcome of patients with lacrimal gland adenoid cystic carcinoma. Ophthalmology. 116(6):1210-5, 2009
Rootman J et al: Changes in the 7th edition of the AJCC TNM classification and recommendations for pathologic analysis of lacrimal gland tumors. Arch Pathol Lab Med. 133(8):1268-71, 2009
Snaathorst J et al: Primary epithelial tumors of the lacrimal gland; a retrospective analysis of 22 patients. Int J Oral Maxillofac Surg. 38(7):751-7, 2009
Weis E et al: Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol. 127(8):1016-28, 2009
Bernardini FP et al: Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol. 19(5):409-13, 2008
Vaidhyanath R et al: Lacrimal fossa lesions: pictorial review of CT and MRI features. Orbit. 27(6):410-8, 2008
Jung WS et al: The radiological spectrum of orbital pathologies that involve the lacrimal gland and the lacrimal fossa. Korean J Radiol. 8(4):336-42, 2007
Perez DE et al: Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases. Otolaryngol Head Neck Surg. 134(2):321-5, 2006
Tse DT et al: Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. Am J Ophthalmol. 141(1):44-53, 2006
Kokemueller H et al: Adenoid cystic carcinoma of the head and neck--a 20 years experience. Int J Oral Maxillofac Surg. 33(1):25-31, 2004
Balchunas WR et al: Lacrimal gland and fossa masses: evaluation by computed tomography and A-mode echography. Radiology. 149(3):751-8, 1983
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Subtypes include adenoid cystic carcinoma (ACCa), adenocarcinoma, squamous cell carcinoma, acinic cell carcinoma, carcinoma ex pleomorphic adenoma, and mucoepidermoid carcinoma
Definitions
Malignant epithelial neoplasm of lacrimal gland
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wang YZ et al: [Value of the apparent diffusion coefficient in diffusion weighted imaging at 3.0T MR for differentiating lacrimal gland tumors.] Zhonghua Yi Xue Za Zhi. 99(1):53-6, 2019
Gündüz AK et al: Overview of benign and malignant lacrimal gland tumors. Curr Opin Ophthalmol. 29(5):458-68, 2018
Young SM et al: Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences. Br J Ophthalmol.103(2):264-8, 2018
Lorenzano D et al: The "wedge sign": an imaging sign for aggressive lacrimal gland disease. Ophthalmology. 124(7):1081-3, 2017
Ableman TB et al: Perineural spread of head and neck cancer: Ophthalmic considerations. J Neurol Surg B Skull Base. 77(2):131-9, 2016
Sanders JC et al: Adenoid cystic carcinoma of the lacrimal gland. Am J Otolaryngol. 37(2):144-7, 2016
Woo KI et al: Current treatment of lacrimal gland carcinoma. Curr Opin Ophthalmol. 27(5):449-56, 2016
von Holstein SL et al: Tumors of the lacrimal gland. Semin Diagn Pathol. 33(3):156-63, 2016
Ahmad SM et al: American Joint Committee on Cancer classification predicts outcome of patients with lacrimal gland adenoid cystic carcinoma. Ophthalmology. 116(6):1210-5, 2009
Rootman J et al: Changes in the 7th edition of the AJCC TNM classification and recommendations for pathologic analysis of lacrimal gland tumors. Arch Pathol Lab Med. 133(8):1268-71, 2009
Snaathorst J et al: Primary epithelial tumors of the lacrimal gland; a retrospective analysis of 22 patients. Int J Oral Maxillofac Surg. 38(7):751-7, 2009
Weis E et al: Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol. 127(8):1016-28, 2009
Bernardini FP et al: Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol. 19(5):409-13, 2008
Vaidhyanath R et al: Lacrimal fossa lesions: pictorial review of CT and MRI features. Orbit. 27(6):410-8, 2008
Jung WS et al: The radiological spectrum of orbital pathologies that involve the lacrimal gland and the lacrimal fossa. Korean J Radiol. 8(4):336-42, 2007
Perez DE et al: Epithelial lacrimal gland tumors: a clinicopathological study of 18 cases. Otolaryngol Head Neck Surg. 134(2):321-5, 2006
Tse DT et al: Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. Am J Ophthalmol. 141(1):44-53, 2006
Kokemueller H et al: Adenoid cystic carcinoma of the head and neck--a 20 years experience. Int J Oral Maxillofac Surg. 33(1):25-31, 2004
Balchunas WR et al: Lacrimal gland and fossa masses: evaluation by computed tomography and A-mode echography. Radiology. 149(3):751-8, 1983
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