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Lactating Adenoma
Laurie Margolies, MD; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Nodular lactational hyperplasia
            • Definitions

              • Well-differentiated, benign breast tumor in pregnant, lactating, or postpartum woman

            IMAGING

            • General Features

              • Ultrasonographic Findings

                • Mammographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      • Image-Guided Biopsy

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. American College of Radiology. ACR appropriateness criteria: breast imaging of pregnant and lactating women. Updated 2018
                                          2. Parker S et al: Spectrum of pregnancy- and lactation-related benign breast findings. Curr Probl Diagn Radiol. 46(6):432-440, 2017
                                          3. Szabo J et al: Spuriously aggressive features of a lactating adenoma prompting repeated biopsies. Radiol Case Rep. 12(2):215-218, 2017
                                          4. Barco Nebreda I et al: Lactating adenoma of the breast. J Hum Lact. 32(3):559-62, 2016
                                          5. Langer A et al: Breast lumps in pregnant women. Diagn Interv Imaging. 96(10):1077-87, 2015
                                          6. Tirada N et al: Imaging pregnant and lactating patients. Radiographics. 35(6):1751-65, 2015
                                          7. Anunobi CC et al: Vulva fibroadenoma associated with lactating adenoma in a 26-year-old nigerian female. Case Rep Pathol. 2013:195703, 2013
                                          8. Joshi S et al: Breast disease in the pregnant and lactating patient: radiological-pathological correlation. Insights Imaging. 4(5):527-38, 2013
                                          9. Parnes AN et al: AIRP best cases in radiologic-pathologic correlation: lactating adenoma. Radiographics. 33(2):455-9, 2013
                                          10. Vashi R et al: Breast imaging of the pregnant and lactating patient: physiologic changes and common benign entities. AJR Am J Roentgenol. 200(2):329-36, 2013
                                          11. Robbins J et al: Accuracy of diagnostic mammography and breast ultrasound during pregnancy and lactation. AJR Am J Roentgenol. 196(3):716-22, 2011
                                          12. Goto M et al: MR imaging of tubular adenoma of breast associated with lactating change. Breast J. 15(5):536-7, 2009
                                          13. Magno S et al: Breast MRI in a case of "early onset" lactating adenoma. Breast J. 15(1):105-6, 2009
                                          14. Sabate JM et al: Radiologic evaluation of breast disorders related to pregnancy and lactation. Radiographics. 27 Suppl 1:S101-24, 2007
                                          15. Saglam A et al: Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman. J Clin Pathol. 58(1):87-9, 2005
                                          16. Baker TP et al: Lactating adenoma: a diagnosis of exclusion. Breast J. 7(5):354-7, 2001
                                          17. Goyal M et al: Palpable breast mass in a lactating woman. Postgrad Med J. 77(909):473, 482-3, 2001
                                          18. Reeves ME et al: Lactating adenoma presenting as a giant breast mass. Surgery. 127(5):586-8, 2000
                                          19. Behrndt VS et al: Infarcted lactating adenoma presenting as a rapidly enlarging breast mass. AJR Am J Roentgenol. 173(4):933-5, 1999
                                          20. Sumkin JH et al: Lactating adenoma: US features and literature review. Radiology. 206(1):271-4, 1998
                                          21. Yang WT et al: Lactating adenoma of the breast: antepartum and postpartum sonographic and color Doppler imaging appearances with histopathologic correlation. J Ultrasound Med. 16(2):145-7, 1997
                                          22. Collins JC et al: Surgical management of breast masses in pregnant women. J Reprod Med. 40(11):785-8, 1995
                                          23. Slavin JL et al: Nodular breast lesions during pregnancy and lactation. Histopathology. 22(5):481-5, 1993
                                          24. Terada S et al: A lactating adenoma of the breast. Gynecol Obstet Invest. 34(2):126-8, 1992
                                          25. James K et al: Breast tumour of pregnancy ('lactating' adenoma). J Pathol. 156(1):37-44, 1988
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Nodular lactational hyperplasia
                                                    • Definitions

                                                      • Well-differentiated, benign breast tumor in pregnant, lactating, or postpartum woman

                                                    IMAGING

                                                    • General Features

                                                      • Ultrasonographic Findings

                                                        • Mammographic Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              • Image-Guided Biopsy

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. American College of Radiology. ACR appropriateness criteria: breast imaging of pregnant and lactating women. Updated 2018
                                                                                  2. Parker S et al: Spectrum of pregnancy- and lactation-related benign breast findings. Curr Probl Diagn Radiol. 46(6):432-440, 2017
                                                                                  3. Szabo J et al: Spuriously aggressive features of a lactating adenoma prompting repeated biopsies. Radiol Case Rep. 12(2):215-218, 2017
                                                                                  4. Barco Nebreda I et al: Lactating adenoma of the breast. J Hum Lact. 32(3):559-62, 2016
                                                                                  5. Langer A et al: Breast lumps in pregnant women. Diagn Interv Imaging. 96(10):1077-87, 2015
                                                                                  6. Tirada N et al: Imaging pregnant and lactating patients. Radiographics. 35(6):1751-65, 2015
                                                                                  7. Anunobi CC et al: Vulva fibroadenoma associated with lactating adenoma in a 26-year-old nigerian female. Case Rep Pathol. 2013:195703, 2013
                                                                                  8. Joshi S et al: Breast disease in the pregnant and lactating patient: radiological-pathological correlation. Insights Imaging. 4(5):527-38, 2013
                                                                                  9. Parnes AN et al: AIRP best cases in radiologic-pathologic correlation: lactating adenoma. Radiographics. 33(2):455-9, 2013
                                                                                  10. Vashi R et al: Breast imaging of the pregnant and lactating patient: physiologic changes and common benign entities. AJR Am J Roentgenol. 200(2):329-36, 2013
                                                                                  11. Robbins J et al: Accuracy of diagnostic mammography and breast ultrasound during pregnancy and lactation. AJR Am J Roentgenol. 196(3):716-22, 2011
                                                                                  12. Goto M et al: MR imaging of tubular adenoma of breast associated with lactating change. Breast J. 15(5):536-7, 2009
                                                                                  13. Magno S et al: Breast MRI in a case of "early onset" lactating adenoma. Breast J. 15(1):105-6, 2009
                                                                                  14. Sabate JM et al: Radiologic evaluation of breast disorders related to pregnancy and lactation. Radiographics. 27 Suppl 1:S101-24, 2007
                                                                                  15. Saglam A et al: Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman. J Clin Pathol. 58(1):87-9, 2005
                                                                                  16. Baker TP et al: Lactating adenoma: a diagnosis of exclusion. Breast J. 7(5):354-7, 2001
                                                                                  17. Goyal M et al: Palpable breast mass in a lactating woman. Postgrad Med J. 77(909):473, 482-3, 2001
                                                                                  18. Reeves ME et al: Lactating adenoma presenting as a giant breast mass. Surgery. 127(5):586-8, 2000
                                                                                  19. Behrndt VS et al: Infarcted lactating adenoma presenting as a rapidly enlarging breast mass. AJR Am J Roentgenol. 173(4):933-5, 1999
                                                                                  20. Sumkin JH et al: Lactating adenoma: US features and literature review. Radiology. 206(1):271-4, 1998
                                                                                  21. Yang WT et al: Lactating adenoma of the breast: antepartum and postpartum sonographic and color Doppler imaging appearances with histopathologic correlation. J Ultrasound Med. 16(2):145-7, 1997
                                                                                  22. Collins JC et al: Surgical management of breast masses in pregnant women. J Reprod Med. 40(11):785-8, 1995
                                                                                  23. Slavin JL et al: Nodular breast lesions during pregnancy and lactation. Histopathology. 22(5):481-5, 1993
                                                                                  24. Terada S et al: A lactating adenoma of the breast. Gynecol Obstet Invest. 34(2):126-8, 1992
                                                                                  25. James K et al: Breast tumour of pregnancy ('lactating' adenoma). J Pathol. 156(1):37-44, 1988