Eosinophilic granuloma, Hand-Schüller-Christian disease, Letterer-Siwe disease, histiocytosis X
Definitions
Langerhans cell histiocytosis (LCH): Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
Leads to formation of destructive granulomas
IMAGING
General Features
Radiographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Della Valle V et al: Chest computed tomography findings for a cohort of children with pulmonary Langerhans cell histiocytosis. Pediatr Blood Cancer. 67(10):e28496, 2020
Jessop S et al: FDG PET-CT in pediatric Langerhans cell histiocytosis. Pediatr Blood Cancer. 67(1):e28034, 2020
Le Louet S et al: Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study. Orphanet J Rare Dis. 15(1):241, 2020
Allen CE et al: Langerhans-Cell histiocytosis. N Engl J Med. 379(9):856-68, 2018
Jezierska M et al: Langerhans cell histiocytosis in children - a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Postepy Dermatol Alergol. 35(1):6-17, 2018
Retraction: 'Imaging characteristics of liver Langerhans cell histiocytosis in children' by Hui Liu, Xueying Long, Xiaoyi Wang, Wenzheng Li and Yigang Pei. Pediatr Int. 59(9):1034, 2017
Ahuja J et al: Histiocytic disorders of the chest: imaging findings. Radiographics. 35(2):357-70, 2015
Bano S et al: Pulmonary Langerhans cell histiocytosis in children: a spectrum of radiologic findings. Eur J Radiol. 83(1):47-56, 2014
Ronceray L et al: Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr. 161(1):129-33.e1-3, 2012
Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2012
Suri HS et al: Pulmonary langerhans cell histiocytosis. Orphanet J Rare Dis. 7:16, 2012
García-Peña P et al: Thoracic findings of systemic diseases at high-resolution CT in children. Radiographics. 31(2):465-82, 2011
Schmidt S et al: Extraosseous langerhans cell histiocytosis in children. Radiographics. 28(3):707-26; quiz 910-1, 2008
Odame I et al: Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer. 47(7):889-93, 2006
Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
Donnelly LF et al: Langerhans' cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR Am J Roentgenol. 174(3):877-8, 2000
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TERMINOLOGY
Synonyms
Eosinophilic granuloma, Hand-Schüller-Christian disease, Letterer-Siwe disease, histiocytosis X
Definitions
Langerhans cell histiocytosis (LCH): Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
Leads to formation of destructive granulomas
IMAGING
General Features
Radiographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Della Valle V et al: Chest computed tomography findings for a cohort of children with pulmonary Langerhans cell histiocytosis. Pediatr Blood Cancer. 67(10):e28496, 2020
Jessop S et al: FDG PET-CT in pediatric Langerhans cell histiocytosis. Pediatr Blood Cancer. 67(1):e28034, 2020
Le Louet S et al: Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study. Orphanet J Rare Dis. 15(1):241, 2020
Allen CE et al: Langerhans-Cell histiocytosis. N Engl J Med. 379(9):856-68, 2018
Jezierska M et al: Langerhans cell histiocytosis in children - a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Postepy Dermatol Alergol. 35(1):6-17, 2018
Retraction: 'Imaging characteristics of liver Langerhans cell histiocytosis in children' by Hui Liu, Xueying Long, Xiaoyi Wang, Wenzheng Li and Yigang Pei. Pediatr Int. 59(9):1034, 2017
Ahuja J et al: Histiocytic disorders of the chest: imaging findings. Radiographics. 35(2):357-70, 2015
Bano S et al: Pulmonary Langerhans cell histiocytosis in children: a spectrum of radiologic findings. Eur J Radiol. 83(1):47-56, 2014
Ronceray L et al: Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr. 161(1):129-33.e1-3, 2012
Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2012
Suri HS et al: Pulmonary langerhans cell histiocytosis. Orphanet J Rare Dis. 7:16, 2012
García-Peña P et al: Thoracic findings of systemic diseases at high-resolution CT in children. Radiographics. 31(2):465-82, 2011
Schmidt S et al: Extraosseous langerhans cell histiocytosis in children. Radiographics. 28(3):707-26; quiz 910-1, 2008
Odame I et al: Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer. 47(7):889-93, 2006
Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
Donnelly LF et al: Langerhans' cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR Am J Roentgenol. 174(3):877-8, 2000
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