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Langerhans Cell Histiocytosis, Pulmonary
Tyler H. Ternes, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Pulmonary Langerhans cell histiocytosis (PLCH)
              • Definitions

                • Peribronchiolar infiltration of stellate nodules that contain Langerhans cells

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Diagnosis

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Seaman DM et al: Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol. 196(6):1305-11, 2011
                                            2. Seely JM et al: Pulmonary Langerhans Cell Histiocytosis: A Comparative Study of Computed Tomography in Children and Adults. J Thorac Imaging. Epub ahead of print, 2010
                                            3. Galvin JR et al: Smoking-related lung disease. J Thorac Imaging. 24(4):274-84, 2009
                                            4. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                            5. Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
                                            6. Vassallo R et al: Pulmonary Langerhans'-cell histiocytosis. N Engl J Med. 342(26):1969-78, 2000
                                            7. Brauner MW et al: Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology. 204(2):497-502, 1997
                                            8. Moore AD et al: Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology. 172(1):249-54, 1989
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Pulmonary Langerhans cell histiocytosis (PLCH)
                                                        • Definitions

                                                          • Peribronchiolar infiltration of stellate nodules that contain Langerhans cells

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Diagnosis

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Seaman DM et al: Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol. 196(6):1305-11, 2011
                                                                                      2. Seely JM et al: Pulmonary Langerhans Cell Histiocytosis: A Comparative Study of Computed Tomography in Children and Adults. J Thorac Imaging. Epub ahead of print, 2010
                                                                                      3. Galvin JR et al: Smoking-related lung disease. J Thorac Imaging. 24(4):274-84, 2009
                                                                                      4. Attili AK et al: Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. Radiographics. 28(5):1383-96; discussion 1396-8, 2008
                                                                                      5. Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
                                                                                      6. Vassallo R et al: Pulmonary Langerhans'-cell histiocytosis. N Engl J Med. 342(26):1969-78, 2000
                                                                                      7. Brauner MW et al: Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology. 204(2):497-502, 1997
                                                                                      8. Moore AD et al: Pulmonary histiocytosis X: comparison of radiographic and CT findings. Radiology. 172(1):249-54, 1989