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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Langerhans cell histiocytosis (LCH)
Synonyms
- Eosinophilic granuloma, Hand-Schüller-Christian disease, Letterer-Siwe disease, histiocytosis X
Definitions
- Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
- Leads to formation of destructive granulomas
- Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
IMAGING
General Features
Radiographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Ahuja J et al: Histiocytic disorders of the chest: imaging findings. Radiographics. 35(2):357-70, 2015
- Bano S et al: Pulmonary Langerhans cell histiocytosis in children: a spectrum of radiologic findings. Eur J Radiol. 83(1):47-56, 2014
- Ronceray L et al: Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr. 161(1):129-33.e1-3, 2012
- Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2012
- García-Peña P et al: Thoracic findings of systemic diseases at high-resolution CT in children. Radiographics. 31(2):465-82, 2011
- Schmidt S et al: Extraosseous langerhans cell histiocytosis in children. Radiographics. 28(3):707-26; quiz 910-1, 2008
- Odame I et al: Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer. 47(7):889-93, 2006
- Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
- Donnelly LF et al: Langerhans' cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR Am J Roentgenol. 174(3):877-8, 2000
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Langerhans cell histiocytosis (LCH)
Synonyms
- Eosinophilic granuloma, Hand-Schüller-Christian disease, Letterer-Siwe disease, histiocytosis X
Definitions
- Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
- Leads to formation of destructive granulomas
- Neoplastic proliferation of monoclonal Langerhans cells in 1 or more organ systems
IMAGING
General Features
Radiographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Ahuja J et al: Histiocytic disorders of the chest: imaging findings. Radiographics. 35(2):357-70, 2015
- Bano S et al: Pulmonary Langerhans cell histiocytosis in children: a spectrum of radiologic findings. Eur J Radiol. 83(1):47-56, 2014
- Ronceray L et al: Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr. 161(1):129-33.e1-3, 2012
- Seely JM et al: Pulmonary Langerhans cell histiocytosis: a comparative study of computed tomography in children and adults. J Thorac Imaging. 27(1):65-70, 2012
- García-Peña P et al: Thoracic findings of systemic diseases at high-resolution CT in children. Radiographics. 31(2):465-82, 2011
- Schmidt S et al: Extraosseous langerhans cell histiocytosis in children. Radiographics. 28(3):707-26; quiz 910-1, 2008
- Odame I et al: Pulmonary Langerhans cell histiocytosis: a variable disease in childhood. Pediatr Blood Cancer. 47(7):889-93, 2006
- Abbott GF et al: From the archives of the AFIP: pulmonary Langerhans cell histiocytosis. Radiographics. 24(3):821-41, 2004
- Donnelly LF et al: Langerhans' cell histiocytosis showing low-attenuation mediastinal mass and cystic lung disease. AJR Am J Roentgenol. 174(3):877-8, 2000
