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Langerhans Cell Histiocytosis, Spine
Lubdha M. Shah, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Synonyms

              • Langerhans cell histiocytosis (LCH), Langerhans cell granulomatosis, eosinophilic granuloma (EG), histiocytosis X
            • Definitions

              • Abnormal histiocyte proliferation producing granulomatous skeletal lesions

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Lee SK et al: Solitary Langerhans cell histocytosis of skull and spine in pediatric and adult patients. Childs Nerv Syst. 30(2):271-5, 2014
                                              2. Huang WD et al: Langerhans cell histiocytosis of spine: a comparative study of clinical, imaging features, and diagnosis in children, adolescents, and adults. Spine J. 13(9):1108-17, 2013
                                              3. Bavbek M et al: Spontaneous resolution of lumbar vertebral eosinophilic granuloma. Acta Neurochir (Wien). 146(2):165-7, 2004
                                              4. Garg S et al: Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am. 86-A(8):1740-50, 2004
                                              5. Kuhn J et al: Caffey's Pediatric Diagnostic Imaging. 10th ed. Philadelphia: Mosby. 704, 2004
                                              6. Simanski C et al: The Langerhans' cell histiocytosis (eosinophilic granuloma) of the cervical spine: a rare diagnosis of cervical pain. Magn Reson Imaging. 22(4):589-94, 2004
                                              7. Fernando Ugarriza L et al: Solitary eosinophilic granuloma of the cervicothoracic junction causing neurological deficit. Br J Neurosurg. 17(2):178-81, 2003
                                              8. Puertas EB et al: Surgical treatment of eosinophilic granuloma in the thoracic spine in patients with neurological lesions. J Pediatr Orthop B. 12(5):303-6, 2003
                                              9. Bertram C et al: Eosinophilic granuloma of the cervical spine. Spine. 27(13):1408-13, 2002
                                              10. Graham D et al: Greenfield's Neuropathology. 7th ed. London: Arnold. 1017-1018, 2002
                                              11. Plasschaert F et al: Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br. 84(6):870-2, 2002
                                              12. Kamimura M et al: Eosinophilic granuloma of the spine: early spontaneous disappearance of tumor detected on magnetic resonance imaging. Case report. J Neurosurg. 93(2 Suppl):312-6, 2000
                                              13. Reddy PK et al: Eosinophilic granuloma of spine in adults: a case report and review of literature. Spinal Cord. 38(12):766-8, 2000
                                              14. Yeom JS et al: Langerhans' cell histiocytosis of the spine. Analysis of twenty-three cases. Spine. 24(16):1740-9, 1999
                                              15. Kandoi M et al: Rapidly progressive polyostotic eosinophilic granuloma involving spine: a case report. Indian J Med Sci. 52(1):22-4, 1998
                                              16. Raab P et al: Vertebral remodeling in eosinophilic granuloma of the spine. A long-term follow-up. Spine. 23(12):1351-4, 1998
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Langerhans cell histiocytosis (LCH), Langerhans cell granulomatosis, eosinophilic granuloma (EG), histiocytosis X
                                                        • Definitions

                                                          • Abnormal histiocyte proliferation producing granulomatous skeletal lesions

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Lee SK et al: Solitary Langerhans cell histocytosis of skull and spine in pediatric and adult patients. Childs Nerv Syst. 30(2):271-5, 2014
                                                                                          2. Huang WD et al: Langerhans cell histiocytosis of spine: a comparative study of clinical, imaging features, and diagnosis in children, adolescents, and adults. Spine J. 13(9):1108-17, 2013
                                                                                          3. Bavbek M et al: Spontaneous resolution of lumbar vertebral eosinophilic granuloma. Acta Neurochir (Wien). 146(2):165-7, 2004
                                                                                          4. Garg S et al: Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am. 86-A(8):1740-50, 2004
                                                                                          5. Kuhn J et al: Caffey's Pediatric Diagnostic Imaging. 10th ed. Philadelphia: Mosby. 704, 2004
                                                                                          6. Simanski C et al: The Langerhans' cell histiocytosis (eosinophilic granuloma) of the cervical spine: a rare diagnosis of cervical pain. Magn Reson Imaging. 22(4):589-94, 2004
                                                                                          7. Fernando Ugarriza L et al: Solitary eosinophilic granuloma of the cervicothoracic junction causing neurological deficit. Br J Neurosurg. 17(2):178-81, 2003
                                                                                          8. Puertas EB et al: Surgical treatment of eosinophilic granuloma in the thoracic spine in patients with neurological lesions. J Pediatr Orthop B. 12(5):303-6, 2003
                                                                                          9. Bertram C et al: Eosinophilic granuloma of the cervical spine. Spine. 27(13):1408-13, 2002
                                                                                          10. Graham D et al: Greenfield's Neuropathology. 7th ed. London: Arnold. 1017-1018, 2002
                                                                                          11. Plasschaert F et al: Eosinophilic granuloma. A different behaviour in children than in adults. J Bone Joint Surg Br. 84(6):870-2, 2002
                                                                                          12. Kamimura M et al: Eosinophilic granuloma of the spine: early spontaneous disappearance of tumor detected on magnetic resonance imaging. Case report. J Neurosurg. 93(2 Suppl):312-6, 2000
                                                                                          13. Reddy PK et al: Eosinophilic granuloma of spine in adults: a case report and review of literature. Spinal Cord. 38(12):766-8, 2000
                                                                                          14. Yeom JS et al: Langerhans' cell histiocytosis of the spine. Analysis of twenty-three cases. Spine. 24(16):1740-9, 1999
                                                                                          15. Kandoi M et al: Rapidly progressive polyostotic eosinophilic granuloma involving spine: a case report. Indian J Med Sci. 52(1):22-4, 1998
                                                                                          16. Raab P et al: Vertebral remodeling in eosinophilic granuloma of the spine. A long-term follow-up. Spine. 23(12):1351-4, 1998