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Large Cell Carcinoma
Sonia L. Betancourt Cuellar, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Large cell lung carcinoma (LCLC)
            • Synonyms

              • Anaplastic carcinoma
            • Definitions

              • Diagnosis of exclusion
                • No features of small cell lung carcinoma or other non-small cell lung carcinomas (NSCLCs) (adenocarcinoma or squamous cell carcinoma)
              • Least common type of NSCLC
              • Most common subtype: Large cell neuroendocrine carcinoma
                • Characteristics common to neuroendocrine tumors and LCLC

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Pelosi G et al: Large cell carcinoma of the lung: A tumor in search of an author. A clinically oriented critical reappraisal. Lung Cancer. ePub, 2015
                                          2. Gollard R et al: Large cell/neuroendocrine carcinoma. Lung Cancer. 69(1):13-8, 2010
                                          3. Chong S et al: Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. Radiographics. 26(1):41-57; discussion 57-8, 2006
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Large cell lung carcinoma (LCLC)
                                                    • Synonyms

                                                      • Anaplastic carcinoma
                                                    • Definitions

                                                      • Diagnosis of exclusion
                                                        • No features of small cell lung carcinoma or other non-small cell lung carcinomas (NSCLCs) (adenocarcinoma or squamous cell carcinoma)
                                                      • Least common type of NSCLC
                                                      • Most common subtype: Large cell neuroendocrine carcinoma
                                                        • Characteristics common to neuroendocrine tumors and LCLC

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Pelosi G et al: Large cell carcinoma of the lung: A tumor in search of an author. A clinically oriented critical reappraisal. Lung Cancer. ePub, 2015
                                                                                  2. Gollard R et al: Large cell/neuroendocrine carcinoma. Lung Cancer. 69(1):13-8, 2010
                                                                                  3. Chong S et al: Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. Radiographics. 26(1):41-57; discussion 57-8, 2006