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Chest
Diagnosis
Pulmonary Neoplasms
Lung Cancer
Large Cell Carcinoma
Large Cell Carcinoma
Sonia L. Betancourt-Cuellar, MD
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Large cell lung carcinoma (LCLC)
Synonyms
Anaplastic carcinoma
Definitions
Diagnosis of exclusion
No features of small cell lung carcinoma or other non-small cell lung carcinomas (NSCLCs) (adenocarcinoma or squamous cell carcinoma)
Least common type of NSCLC
Most common subtype: Large cell neuroendocrine carcinoma
Characteristics common to neuroendocrine tumors and LCLC
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Pelosi G et al: Large cell carcinoma of the lung: A tumor in search of an author. A clinically oriented critical reappraisal. Lung Cancer. ePub, 2015
Gollard R et al: Large cell/neuroendocrine carcinoma. Lung Cancer. 69(1):13-8, 2010
Chong S et al: Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. Radiographics. 26(1):41-57; discussion 57-8, 2006
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Large cell lung carcinoma (LCLC)
Synonyms
Anaplastic carcinoma
Definitions
Diagnosis of exclusion
No features of small cell lung carcinoma or other non-small cell lung carcinomas (NSCLCs) (adenocarcinoma or squamous cell carcinoma)
Least common type of NSCLC
Most common subtype: Large cell neuroendocrine carcinoma
Characteristics common to neuroendocrine tumors and LCLC
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Pelosi G et al: Large cell carcinoma of the lung: A tumor in search of an author. A clinically oriented critical reappraisal. Lung Cancer. ePub, 2015
Gollard R et al: Large cell/neuroendocrine carcinoma. Lung Cancer. 69(1):13-8, 2010
Chong S et al: Neuroendocrine tumors of the lung: clinical, pathologic, and imaging findings. Radiographics. 26(1):41-57; discussion 57-8, 2006
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