Left ventricular noncompaction cardiomyopathy (LVNC)
Synonyms
Noncompacted left ventricle (NCLV), left ventricular hypertrabeculation, spongy myocardium
Definitions
Inherited cardiomyopathy characterized by extensive hypertrabeculation of left ventricular (LV) myocardium
2-layer appearance of LV with sponge-like noncompacted (NC) inner layer & thinner, dense compacted (C) outer layer
Primitive appearance of myocardium suggests potential arrest in fetal LV myocardial development
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Echocardiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Di Fusco SA et al: Left ventricular noncompaction: diagnostic approach, prognostic evaluation, and management strategies. Cardiol Rev. 28(3):125-34, 2020
Rao K et al: The role of multimodality imaging in the diagnosis of left ventricular noncompaction. Eur J Clin Invest. 50(9):e13254, 2020
Fennira S et al: [Left ventricular non-compaction: what should be known!.] Ann Cardiol Angeiol (Paris). 68(2):120-4, 2019
Wengrofsky P et al: Left ventricular trabeculation and noncompaction cardiomyopathy: a review. EC Clin Exp Anat. 2(6):267-83, 2019
Amzulescu MS et al: Prognostic impact of hypertrabeculation and noncompaction phenotype in dilated cardiomyopathy: a CMR study. JACC Cardiovasc Imaging. 8(8):934-46, 2015
Jefferies JL et al: Cardiomyopathy phenotypes and outcomes for children with left ventricular myocardial noncompaction: results from the pediatric cardiomyopathy registry. J Card Fail. 21(11):877-84, 2015
Towbin JA et al: Left ventricular non-compaction cardiomyopathy. Lancet. 386(9995):813-25, 2015
Stacey RB et al: Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc Imaging. 6(9):931-40, 2013
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Abbreviations
Left ventricular noncompaction cardiomyopathy (LVNC)
Synonyms
Noncompacted left ventricle (NCLV), left ventricular hypertrabeculation, spongy myocardium
Definitions
Inherited cardiomyopathy characterized by extensive hypertrabeculation of left ventricular (LV) myocardium
2-layer appearance of LV with sponge-like noncompacted (NC) inner layer & thinner, dense compacted (C) outer layer
Primitive appearance of myocardium suggests potential arrest in fetal LV myocardial development
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Echocardiographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Di Fusco SA et al: Left ventricular noncompaction: diagnostic approach, prognostic evaluation, and management strategies. Cardiol Rev. 28(3):125-34, 2020
Rao K et al: The role of multimodality imaging in the diagnosis of left ventricular noncompaction. Eur J Clin Invest. 50(9):e13254, 2020
Fennira S et al: [Left ventricular non-compaction: what should be known!.] Ann Cardiol Angeiol (Paris). 68(2):120-4, 2019
Wengrofsky P et al: Left ventricular trabeculation and noncompaction cardiomyopathy: a review. EC Clin Exp Anat. 2(6):267-83, 2019
Amzulescu MS et al: Prognostic impact of hypertrabeculation and noncompaction phenotype in dilated cardiomyopathy: a CMR study. JACC Cardiovasc Imaging. 8(8):934-46, 2015
Jefferies JL et al: Cardiomyopathy phenotypes and outcomes for children with left ventricular myocardial noncompaction: results from the pediatric cardiomyopathy registry. J Card Fail. 21(11):877-84, 2015
Towbin JA et al: Left ventricular non-compaction cardiomyopathy. Lancet. 386(9995):813-25, 2015
Stacey RB et al: Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc Imaging. 6(9):931-40, 2013
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