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Lewy Body Dementia
Akiva Mintz, MD, PhD, MHA, CFA; Bryan J. Neth, BS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Lewy body disease (LBD)
              • Lewy body variant (LBV) of Alzheimer disease (AD)
            • Synonyms

              • Dementia with Lewy bodies
            • Definitions

              • Progressive neurodegenerative disease of brain characterized by parkinsonism, visual hallucinations, fluctuations in cognition (alertness/attention), and other cognitive impairments leading to functional decline

            IMAGING

            • General Features

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Gross Pathologic & Surgical Features

                      CLINICAL ISSUES

                      • Presentation

                        • Natural History & Prognosis

                          • Treatment

                            DIAGNOSTIC CHECKLIST

                            • Image Interpretation Pearls

                              Selected References

                              1. Ishii K: PET Approaches for diagnosis of dementia. AJNR Am J Neuroradiol. 35(11):2030-8, 2014
                              2. Siderowf A et al: PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer's disease and Lewy body disorders. BMC Neurol. 14(1):79, 2014
                              3. Colloby SJ et al: Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain. 135(Pt 9):2798-808, 2012
                              4. Treglia G et al: Diagnostic performance of myocardial innervation imaging using MIBG scintigraphy in differential diagnosis between dementia with lewy bodies and other dementias: a systematic review and a meta-analysis. J Neuroimaging. 22(2):111-7, 2012
                              5. Kantarci K et al: Dementia with Lewy bodies and Alzheimer disease: neurodegenerative patterns characterized by DTI. Neurology. 74(22):1814-21, 2010
                              6. Mrak RE et al: Dementia with Lewy bodies: definition, diagnosis, and pathogenic relationship to Alzheimer's disease. Neuropsychiatr Dis Treat. 3(5):619-25, 2007
                              7. Weisman D et al: Dementia with Lewy bodies. Semin Neurol. 27(1):42-7, 2007
                              8. Whitwell JL et al: Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain. 130(Pt 3):708-19, 2007
                              9. Bozzali M et al: Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain. 128(Pt 7):1595-604, 2005
                              10. McKeith IG et al: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19. Review. Erratum in: Neurology. 65(12):1992, 2005
                              11. Minoshima S et al: Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol. 50(3):358-65, 2001
                              12. Barber R et al: MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia. Neurology. 54(6):1304-9, 2000
                              13. Hu XS et al: 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology. 55(10):1575-7, 2000
                              Related Anatomy
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                              Related Differential Diagnoses
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                              References
                              Tables

                              Tables

                              KEY FACTS

                              • Terminology

                                • Imaging

                                  • Top Differential Diagnoses

                                    • Pathology

                                      • Clinical Issues

                                        TERMINOLOGY

                                        • Abbreviations

                                          • Lewy body disease (LBD)
                                          • Lewy body variant (LBV) of Alzheimer disease (AD)
                                        • Synonyms

                                          • Dementia with Lewy bodies
                                        • Definitions

                                          • Progressive neurodegenerative disease of brain characterized by parkinsonism, visual hallucinations, fluctuations in cognition (alertness/attention), and other cognitive impairments leading to functional decline

                                        IMAGING

                                        • General Features

                                          • Imaging Recommendations

                                            DIFFERENTIAL DIAGNOSIS

                                              PATHOLOGY

                                              • General Features

                                                • Gross Pathologic & Surgical Features

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Natural History & Prognosis

                                                      • Treatment

                                                        DIAGNOSTIC CHECKLIST

                                                        • Image Interpretation Pearls

                                                          Selected References

                                                          1. Ishii K: PET Approaches for diagnosis of dementia. AJNR Am J Neuroradiol. 35(11):2030-8, 2014
                                                          2. Siderowf A et al: PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer's disease and Lewy body disorders. BMC Neurol. 14(1):79, 2014
                                                          3. Colloby SJ et al: Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. Brain. 135(Pt 9):2798-808, 2012
                                                          4. Treglia G et al: Diagnostic performance of myocardial innervation imaging using MIBG scintigraphy in differential diagnosis between dementia with lewy bodies and other dementias: a systematic review and a meta-analysis. J Neuroimaging. 22(2):111-7, 2012
                                                          5. Kantarci K et al: Dementia with Lewy bodies and Alzheimer disease: neurodegenerative patterns characterized by DTI. Neurology. 74(22):1814-21, 2010
                                                          6. Mrak RE et al: Dementia with Lewy bodies: definition, diagnosis, and pathogenic relationship to Alzheimer's disease. Neuropsychiatr Dis Treat. 3(5):619-25, 2007
                                                          7. Weisman D et al: Dementia with Lewy bodies. Semin Neurol. 27(1):42-7, 2007
                                                          8. Whitwell JL et al: Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease. Brain. 130(Pt 3):708-19, 2007
                                                          9. Bozzali M et al: Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain. 128(Pt 7):1595-604, 2005
                                                          10. McKeith IG et al: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19. Review. Erratum in: Neurology. 65(12):1992, 2005
                                                          11. Minoshima S et al: Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol. 50(3):358-65, 2001
                                                          12. Barber R et al: MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia. Neurology. 54(6):1304-9, 2000
                                                          13. Hu XS et al: 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology. 55(10):1575-7, 2000