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Interstitial, Diffuse, and Inhalational Lung Disease
Metabolic Diseases and Miscellaneous Conditions
Light-Chain Deposition Disease
Light-Chain Deposition Disease
Takeshi Johkoh, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Light-chain deposition disease (LCDD)

            • Definitions

              • Rare condition characterized by systemic extracellular accumulation of immunoglobulin light chains commonly involving kidneys, liver, and heart
                • Deposition of amorphous nonfibrillary material; does not contain amyloid fibrils
                • Does not have β-pleated sheet configuration and consequently does not bind Congo red, unlike amyloidosis

            IMAGING

            • Radiographic Findings

              • CT Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  Selected References

                                  1. Sheard S et al: Pulmonary light-chain deposition disease: CT and pathology findings in nine patients. Clin Radiol. 70(5):515-22, 2015
                                  2. Rho L et al: Pulmonary manifestations of light chain deposition disease. Respirology. 14(5):767-70, 2009
                                  3. Colombat M et al: Pathomechanisms of cyst formation in pulmonary light chain deposition disease. Eur Respir J. 32(5):1399-403, 2008
                                  4. Bhargava P et al: Pulmonary light chain deposition disease: report of five cases and review of the literature. Am J Surg Pathol. 31(2):267-76, 2007
                                  5. Colombat M et al: Pulmonary cystic disorder related to light chain deposition disease. Am J Respir Crit Care Med. 173(7):777-80, 2006
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Light-chain deposition disease (LCDD)

                                            • Definitions

                                              • Rare condition characterized by systemic extracellular accumulation of immunoglobulin light chains commonly involving kidneys, liver, and heart
                                                • Deposition of amorphous nonfibrillary material; does not contain amyloid fibrils
                                                • Does not have β-pleated sheet configuration and consequently does not bind Congo red, unlike amyloidosis

                                            IMAGING

                                            • Radiographic Findings

                                              • CT Findings

                                                • Imaging Recommendations

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Gross Pathologic & Surgical Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Demographics

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  Selected References

                                                                  1. Sheard S et al: Pulmonary light-chain deposition disease: CT and pathology findings in nine patients. Clin Radiol. 70(5):515-22, 2015
                                                                  2. Rho L et al: Pulmonary manifestations of light chain deposition disease. Respirology. 14(5):767-70, 2009
                                                                  3. Colombat M et al: Pathomechanisms of cyst formation in pulmonary light chain deposition disease. Eur Respir J. 32(5):1399-403, 2008
                                                                  4. Bhargava P et al: Pulmonary light chain deposition disease: report of five cases and review of the literature. Am J Surg Pathol. 31(2):267-76, 2007
                                                                  5. Colombat M et al: Pulmonary cystic disorder related to light chain deposition disease. Am J Respir Crit Care Med. 173(7):777-80, 2006