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Lipoma of Bone
Behrang Amini, MD, PhD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Intraosseous lipoma, intramedullary lipoma, intracortical lipoma, parosteal lipoma
        • Definitions

          • Strict definition: benign neoplasm composed of white adipocytes that arise within or on surface of bone
          • Some refer to any localized fat in bone as lipomas; focal fat may be result of healing injury or involuting lesions
            • Fatty conversion of simple bone cysts and screw or biopsy tracts

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • Gross Pathologic & Surgical Features

                    • Microscopic Features

                      CLINICAL ISSUES

                      • Presentation

                        • Demographics

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                Selected References

                                1. Tins BJ et al: Intraosseous lipomas originating from simple bone cysts. Skeletal Radiol. 50(4):801-6, 2021
                                2. Rosenberg AE et al: Lipoma and hibernoma of bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 475-7, 2020
                                3. Malghem J et al: Calcaneal cysts and lipomas: a common pathogenesis? Skeletal Radiol. 46(12):1635-42, 2017
                                4. Aumar DK et al: Intraosseous lipoma of the calcaneus: report of a case and review of the literature. J Foot Ankle Surg. 52(3):360-3, 2013
                                5. Mannem RR et al: AIRP best cases in radiologic-pathologic correlation: intraosseous lipoma. Radiographics. 32(5):1523-8, 2012
                                6. Eyzaguirre E et al: Intraosseous lipoma. A clinical, radiologic, and pathologic study of 5 cases. Ann Diagn Pathol. 11(5):320-5, 2007
                                7. Kapukaya A et al: Osseous lipoma: eleven new cases and review of the literature. Acta Orthop Belg. 72(5):603-14, 2006
                                8. Kwak HS et al: On the AJR viewbox. MR findings of calcaneal intraosseous lipoma with hemorrhage. AJR Am J Roentgenol. 185(5):1378-9, 2005
                                9. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                10. Ozdemir H et al: MRI findings of intraosseous lipoma: case report. Magn Reson Imaging. 22(2):281-4, 2004
                                11. Radl R et al: Intraosseous lipoma: retrospective analysis of 29 patients. Int Orthop. 28(6):374-8, 2004
                                12. Campbell RS et al: Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol. 32(4):209-22, 2003
                                13. Goto T et al: Intraosseous lipoma: a clinical study of 12 patients. J Orthop Sci. 7(2):274-80, 2002
                                14. Kamekura S et al: Involuted intraosseous lipoma of the sacrum showing high signal intensity on T1-weighted magnetic resonance imaging (MRI). J Orthop Sci. 6(2):183-6, 2001
                                15. Propeck T et al: Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol. 175(3):673-8, 2000
                                16. Blacksin MF et al: Magnetic resonance imaging of intraosseous lipomas: a radiologic-pathologic correlation. Skeletal Radiol. 24(1):37-41, 1995
                                17. Milgram JW: Malignant transformation in bone lipomas. Skeletal Radiol. 19(5):347-52, 1990
                                18. Milgram JW: Intraosseous lipomas: radiologic and pathologic manifestations. Radiology. 167(1):155-60, 1988
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Synonyms

                                        • Intraosseous lipoma, intramedullary lipoma, intracortical lipoma, parosteal lipoma
                                      • Definitions

                                        • Strict definition: benign neoplasm composed of white adipocytes that arise within or on surface of bone
                                        • Some refer to any localized fat in bone as lipomas; focal fat may be result of healing injury or involuting lesions
                                          • Fatty conversion of simple bone cysts and screw or biopsy tracts

                                      IMAGING

                                      • General Features

                                        • Radiographic Findings

                                          • CT Findings

                                            • MR Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • Gross Pathologic & Surgical Features

                                                  • Microscopic Features

                                                    CLINICAL ISSUES

                                                    • Presentation

                                                      • Demographics

                                                        • Natural History & Prognosis

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              Selected References

                                                              1. Tins BJ et al: Intraosseous lipomas originating from simple bone cysts. Skeletal Radiol. 50(4):801-6, 2021
                                                              2. Rosenberg AE et al: Lipoma and hibernoma of bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 475-7, 2020
                                                              3. Malghem J et al: Calcaneal cysts and lipomas: a common pathogenesis? Skeletal Radiol. 46(12):1635-42, 2017
                                                              4. Aumar DK et al: Intraosseous lipoma of the calcaneus: report of a case and review of the literature. J Foot Ankle Surg. 52(3):360-3, 2013
                                                              5. Mannem RR et al: AIRP best cases in radiologic-pathologic correlation: intraosseous lipoma. Radiographics. 32(5):1523-8, 2012
                                                              6. Eyzaguirre E et al: Intraosseous lipoma. A clinical, radiologic, and pathologic study of 5 cases. Ann Diagn Pathol. 11(5):320-5, 2007
                                                              7. Kapukaya A et al: Osseous lipoma: eleven new cases and review of the literature. Acta Orthop Belg. 72(5):603-14, 2006
                                                              8. Kwak HS et al: On the AJR viewbox. MR findings of calcaneal intraosseous lipoma with hemorrhage. AJR Am J Roentgenol. 185(5):1378-9, 2005
                                                              9. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                                              10. Ozdemir H et al: MRI findings of intraosseous lipoma: case report. Magn Reson Imaging. 22(2):281-4, 2004
                                                              11. Radl R et al: Intraosseous lipoma: retrospective analysis of 29 patients. Int Orthop. 28(6):374-8, 2004
                                                              12. Campbell RS et al: Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol. 32(4):209-22, 2003
                                                              13. Goto T et al: Intraosseous lipoma: a clinical study of 12 patients. J Orthop Sci. 7(2):274-80, 2002
                                                              14. Kamekura S et al: Involuted intraosseous lipoma of the sacrum showing high signal intensity on T1-weighted magnetic resonance imaging (MRI). J Orthop Sci. 6(2):183-6, 2001
                                                              15. Propeck T et al: Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol. 175(3):673-8, 2000
                                                              16. Blacksin MF et al: Magnetic resonance imaging of intraosseous lipomas: a radiologic-pathologic correlation. Skeletal Radiol. 24(1):37-41, 1995
                                                              17. Milgram JW: Malignant transformation in bone lipomas. Skeletal Radiol. 19(5):347-52, 1990
                                                              18. Milgram JW: Intraosseous lipomas: radiologic and pathologic manifestations. Radiology. 167(1):155-60, 1988