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Lipoma of Soft Tissue
Eric Walker, MD, MHA, FACR, FACHE; Stephanie A. Bernard, MD; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Definitions

          • Lipoma = benign tumor composed of mature adipocytes
          • Atypical lipomatous tumor (ALT) = well-differentiated liposarcoma (WDL) superficially or in extremities

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        • Reporting Tips

                                          Selected References

                                          1. Charifa A et al: Lipoma pathology. StatPearls, 2021
                                          2. Sciot R: MDM2 amplified sarcomas: a literature review. Diagnostics (Basel). 11(3), 2021
                                          3. Fritchie KJ et al: Lipoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 13-5, 2020
                                          4. Johnson CN et al: Lipomatous soft-tissue tumors. J Am Acad Orthop Surg. 26(22):779-88, 2018
                                          5. Khashper A et al: Imaging characteristics of spindle cell lipoma and its variants. Skeletal Radiol. 43(5):591-7, 2014
                                          6. Kirwadi A et al: MR imaging features of spindle cell lipoma. Skeletal Radiol. 43(2):191-6, 2014
                                          7. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 102-5, 2014
                                          8. Brisson M et al: MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. Skeletal Radiol. 42(5):635-47, 2013
                                          9. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                          10. Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
                                          11. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                          12. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 431-6, 2008
                                          13. Bancroft LW et al: Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skeletal Radiol. 35(10):719-33, 2006
                                          14. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins. 81-4, 2006
                                          15. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                          16. Kransdorf MJ et al: Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology. 224(1):99-104, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Definitions

                                                  • Lipoma = benign tumor composed of mature adipocytes
                                                  • Atypical lipomatous tumor (ALT) = well-differentiated liposarcoma (WDL) superficially or in extremities

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          • Ultrasonographic Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              • Image Interpretation Pearls

                                                                                • Reporting Tips

                                                                                  Selected References

                                                                                  1. Charifa A et al: Lipoma pathology. StatPearls, 2021
                                                                                  2. Sciot R: MDM2 amplified sarcomas: a literature review. Diagnostics (Basel). 11(3), 2021
                                                                                  3. Fritchie KJ et al: Lipoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 13-5, 2020
                                                                                  4. Johnson CN et al: Lipomatous soft-tissue tumors. J Am Acad Orthop Surg. 26(22):779-88, 2018
                                                                                  5. Khashper A et al: Imaging characteristics of spindle cell lipoma and its variants. Skeletal Radiol. 43(5):591-7, 2014
                                                                                  6. Kirwadi A et al: MR imaging features of spindle cell lipoma. Skeletal Radiol. 43(2):191-6, 2014
                                                                                  7. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 102-5, 2014
                                                                                  8. Brisson M et al: MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. Skeletal Radiol. 42(5):635-47, 2013
                                                                                  9. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                                                                  10. Walker EA et al: Magnetic resonance imaging of soft-tissue masses. Semin Roentgenol. 45(4):277-97, 2010
                                                                                  11. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                                                                  12. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 431-6, 2008
                                                                                  13. Bancroft LW et al: Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skeletal Radiol. 35(10):719-33, 2006
                                                                                  14. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins. 81-4, 2006
                                                                                  15. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                                                                  16. Kransdorf MJ et al: Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology. 224(1):99-104, 2002