Esther H. Y. Hung, MBChB, FRCR, FHKCR, FHKAM (Radiology); James F. Griffith, MD, MRCP, FRCR
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KEY FACTS
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Fatty tumor
Definitions
Benign
Lipoma: Benign soft tissue tumor composed of mature adipose tissue
Angiolipoma: Lipoma in which small capillary-sized vessels containing microthrombi transverse tumor
Lipomatosis: Diffuse infiltrative overgrowth of mature adipose tissue, completely or partially encapsulated
Lipomatosis of nerve: Median > > > other nerves ± localized mesenchymal overgrowth
Spindle cell lipoma: Mixture of fat and spindle cells; more common in head and neck subcutaneous tissues and adult males
Lipoblastoma: Admixture of mature and immature adipocytes; more common in extremities and children < 3 years old
Hibernoma: Tumor of brown (thermogenic) fat similar to that found in hibernating animals; > subcutaneous tissues of adults, especially lower neck, mediastinum, and upper dorsal region
Chondroid lipoma: Adult females, shoulder or pelvic girdle, may calcify
Myolipoma: Benign tumor exhibiting features of mature smooth muscles and mature adipose tissue
Lipoma arborescens: Subsynovial fatty proliferation, knee > > > ankle or hip; may occur in tendon sheath
Intermediate
Well-differentiated liposarcoma: Slow-growing, usually deep-seated tumor that does not metastasize but is prone to local recurrence; dedifferentiation risk: 6%
Malignant
Dedifferentiated liposarcoma: Deep-seated and large with significant (> 25%) nonfatty component; malignant potential
Myxoid liposarcoma: Myxoid tumor either low grade (< 5% round cell component) or high grade (> 5% round cell component)
Pleomorphic liposarcoma: Large mass with myxoid, necrotic, fatty, and hemorrhagic components
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gupta P et al: Spectrum of fat-containing soft-tissue masses at MR imaging: the common, the uncommon, the characteristic, and the sometimes confusing. Radiographics. 36(3):753-66, 2016
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Imaging
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Fatty tumor
Definitions
Benign
Lipoma: Benign soft tissue tumor composed of mature adipose tissue
Angiolipoma: Lipoma in which small capillary-sized vessels containing microthrombi transverse tumor
Lipomatosis: Diffuse infiltrative overgrowth of mature adipose tissue, completely or partially encapsulated
Lipomatosis of nerve: Median > > > other nerves ± localized mesenchymal overgrowth
Spindle cell lipoma: Mixture of fat and spindle cells; more common in head and neck subcutaneous tissues and adult males
Lipoblastoma: Admixture of mature and immature adipocytes; more common in extremities and children < 3 years old
Hibernoma: Tumor of brown (thermogenic) fat similar to that found in hibernating animals; > subcutaneous tissues of adults, especially lower neck, mediastinum, and upper dorsal region
Chondroid lipoma: Adult females, shoulder or pelvic girdle, may calcify
Myolipoma: Benign tumor exhibiting features of mature smooth muscles and mature adipose tissue
Lipoma arborescens: Subsynovial fatty proliferation, knee > > > ankle or hip; may occur in tendon sheath
Intermediate
Well-differentiated liposarcoma: Slow-growing, usually deep-seated tumor that does not metastasize but is prone to local recurrence; dedifferentiation risk: 6%
Malignant
Dedifferentiated liposarcoma: Deep-seated and large with significant (> 25%) nonfatty component; malignant potential
Myxoid liposarcoma: Myxoid tumor either low grade (< 5% round cell component) or high grade (> 5% round cell component)
Pleomorphic liposarcoma: Large mass with myxoid, necrotic, fatty, and hemorrhagic components
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Gupta P et al: Spectrum of fat-containing soft-tissue masses at MR imaging: the common, the uncommon, the characteristic, and the sometimes confusing. Radiographics. 36(3):753-66, 2016
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