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Lipomatosis
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Infiltrating lipoma, diffuse congenital lipomatosis, Madelung disease, Launois-Bensaude syndrome, Dercum syndrome
            • Definitions

              • Diffuse overgrowth or regional deposition of mature adipose tissue
              • Found in multiple clinical situations and syndromes
                • Variety of body parts potentially involved
            • Subtypes

              • Diffuse lipomatosis, multiple symmetrical lipomatosis, pelvic lipomatosis, steroid lipomatosis, HIV lipodystrophy

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • Gross Pathologic & Surgical Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Natural History & Prognosis

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Lemaitre M et al: Multiple symmetric and multiple familial lipomatosis. Presse Med. 50(3):104077, 2021
                                  2. Rosenberg AE et al: Lipomatosis. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 16-7, 2020
                                  3. Concepcion E et al: Mediastinal lipomatosis presenting as persistent pneumonia. J Pediatr. 167(2):493-493.e1, 2015
                                  4. Garcia-Ortega DY et al: Parapharyngeal space lipomatosis with secondary dyspnea, disphagia and disphonia. Int J Surg Case Rep. 15:54-6, 2015
                                  5. Michael GA et al: Neuroimaging findings in encephalocraniocutaneous lipomatosis. Pediatr Neurol. 53(5):462-3, 2015
                                  6. Park KH et al: Multiple symmetric lipomatosis presenting with bilateral brachial plexopathy. J Clin Neurol. 11(4):400-1, 2015
                                  7. Petscavage-Thomas JM et al: Imaging findings of adiposis dolorosa vs. massive localized lymphedema. Skeletal Radiol. 44(6):839-47, 2015
                                  8. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 140-6, 2014
                                  9. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                  10. Al-Khawaja D et al: Spinal epidural lipomatosis--a brief review. J Clin Neurosci. 15(12):1323-6, 2008
                                  11. Puttarajappa C et al: Mediastinal lipomatosis as a cause of low voltage complexes on electrocardiogram and widened mediastinum: a case report. Cases J. 1(1):171, 2008
                                  12. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 461-5, 2008
                                  13. Dhawan SS et al: Atypical mediastinal lipomatosis. Heart Lung. 36(3):223-5, 2007
                                  14. Moog U et al: Brain anomalies in encephalocraniocutaneous lipomatosis. Am J Med Genet A. 143A(24):2963-72, 2007
                                  15. Torshizy H et al: Inflammation of Hoffa's fat pad in the setting of HIV: magnetic resonance imaging findings in six patients. Skeletal Radiol. 36(1):35-40, 2007
                                  16. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                  17. Rha SE et al: The renal sinus: pathologic spectrum and multimodality imaging approach. Radiographics. 24 Suppl 1:S117-31, 2004
                                  18. Nielsen GP et al: Lipomatosis. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 23-4, 2002
                                  19. Gámez J et al: Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA. Neurology. 51(1):258-60, 1998
                                  Related Anatomy
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                                  Related Differential Diagnoses
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                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Pathology

                                        • Clinical Issues

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Synonyms

                                              • Infiltrating lipoma, diffuse congenital lipomatosis, Madelung disease, Launois-Bensaude syndrome, Dercum syndrome
                                            • Definitions

                                              • Diffuse overgrowth or regional deposition of mature adipose tissue
                                              • Found in multiple clinical situations and syndromes
                                                • Variety of body parts potentially involved
                                            • Subtypes

                                              • Diffuse lipomatosis, multiple symmetrical lipomatosis, pelvic lipomatosis, steroid lipomatosis, HIV lipodystrophy

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • Radiographic Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • Gross Pathologic & Surgical Features

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              DIAGNOSTIC CHECKLIST

                                                              • Consider

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Lemaitre M et al: Multiple symmetric and multiple familial lipomatosis. Presse Med. 50(3):104077, 2021
                                                                  2. Rosenberg AE et al: Lipomatosis. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 16-7, 2020
                                                                  3. Concepcion E et al: Mediastinal lipomatosis presenting as persistent pneumonia. J Pediatr. 167(2):493-493.e1, 2015
                                                                  4. Garcia-Ortega DY et al: Parapharyngeal space lipomatosis with secondary dyspnea, disphagia and disphonia. Int J Surg Case Rep. 15:54-6, 2015
                                                                  5. Michael GA et al: Neuroimaging findings in encephalocraniocutaneous lipomatosis. Pediatr Neurol. 53(5):462-3, 2015
                                                                  6. Park KH et al: Multiple symmetric lipomatosis presenting with bilateral brachial plexopathy. J Clin Neurol. 11(4):400-1, 2015
                                                                  7. Petscavage-Thomas JM et al: Imaging findings of adiposis dolorosa vs. massive localized lymphedema. Skeletal Radiol. 44(6):839-47, 2015
                                                                  8. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 140-6, 2014
                                                                  9. Walker EA et al: Magnetic resonance imaging of benign soft tissue neoplasms in adults. Radiol Clin North Am. 49(6):1197-217, vi, 2011
                                                                  10. Al-Khawaja D et al: Spinal epidural lipomatosis--a brief review. J Clin Neurosci. 15(12):1323-6, 2008
                                                                  11. Puttarajappa C et al: Mediastinal lipomatosis as a cause of low voltage complexes on electrocardiogram and widened mediastinum: a case report. Cases J. 1(1):171, 2008
                                                                  12. Weiss SW et al: Benign lipomatous tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 461-5, 2008
                                                                  13. Dhawan SS et al: Atypical mediastinal lipomatosis. Heart Lung. 36(3):223-5, 2007
                                                                  14. Moog U et al: Brain anomalies in encephalocraniocutaneous lipomatosis. Am J Med Genet A. 143A(24):2963-72, 2007
                                                                  15. Torshizy H et al: Inflammation of Hoffa's fat pad in the setting of HIV: magnetic resonance imaging findings in six patients. Skeletal Radiol. 36(1):35-40, 2007
                                                                  16. Murphey MD et al: From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 24(5):1433-66, 2004
                                                                  17. Rha SE et al: The renal sinus: pathologic spectrum and multimodality imaging approach. Radiographics. 24 Suppl 1:S117-31, 2004
                                                                  18. Nielsen GP et al: Lipomatosis. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 23-4, 2002
                                                                  19. Gámez J et al: Familial multiple symmetric lipomatosis associated with the A8344G mutation of mitochondrial DNA. Neurology. 51(1):258-60, 1998