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Lipomatous Hypertrophy, Interatrial Septum
Suhny Abbara, MD, FACR, FSCCT
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Lipomatous hypertrophy of interatrial septum (LHIS or LHIAS)
            • Synonyms

              • Lipomatous hypertrophy of atrial septum
              • Lipomatous hamartoma
              • Lipomatous hyperplasia
              • Massive fatty deposits
            • Definitions

              • Nonneoplastic deposition of excessive amounts of fat within interatrial septum
                • 1st described in 1964 by JT Prior
              • Not true neoplasm

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Nuclear Medicine Findings

                        • Echocardiographic Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Coulier B et al: Lipomatous hypertrophy of interatrial septum causing hot spot on 18FDG PET/CT. Diagn Interv Imaging. 100(3):197-8, 2019
                                              2. Rocha RV et al: Adipose tumors of the heart. J Card Surg. 33(8):432-7, 2018
                                              3. Motwani M et al: MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 268(1):26-43, 2013
                                              4. Lee SH et al: Visceral obesity of the heart: extensive lipomatous hypertrophy of interatrial septum. J Cardiovasc Ultrasound. 20(3):161-2, 2012
                                              5. Rigatelli G et al: Anatomo-functional characterization of interatrial septum for catheter-based interventions. Am J Cardiovasc Dis. 1(3):227-35, 2011
                                              6. Pugliatti P et al: Lipomatous hypertrophy of the interatrial septum. Int J Cardiol. 130(2):294-5, 2008
                                              7. Tugcu A et al: Lipomatous hypertrophy of the interatrial septum presenting as an obstructive right atrial mass in a patient with exertional dyspnea. J Am Soc Echocardiogr. 20(11):1319.e3-5, 2007
                                              8. Fan CM et al: Lipomatous hypertrophy of the interatrial septum: increased uptake on FDG PET. AJR Am J Roentgenol. 184(1):339-42, 2005
                                              9. Kuester LB et al: Lipomatous hypertrophy of the interatrial septum: prevalence and features on fusion 18F fluorodeoxyglucose positron emission tomography/CT. Chest. 128(6):3888-93, 2005
                                              10. Heyer CM et al: Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms. Chest. 124(6):2068-73, 2003
                                              11. Iacovoni A et al: [Lipomatous hypertrophy of the interatrial septum: its assessment with TEE, CT and MRI.] G Ital Cardiol. 28(11):1273-7, 1998
                                              12. Meaney JF et al: CT appearance of lipomatous hypertrophy of the interatrial septum. AJR Am J Roentgenol. 168(4):1081-4, 1997
                                              13. Burke AP et al: Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass. Am J Surg Pathol. 20(6):678-85, 1996
                                              14. Shirani J et al: Clinical, electrocardiographic and morphologic features of massive fatty deposits ("lipomatous hypertrophy") in the atrial septum. J Am Coll Cardiol. 22(1):226-38, 1993
                                              15. Lund JT et al: Cardiac masses: assessment by MR imaging. AJR Am J Roentgenol. 152(3):469-73, 1989
                                              16. Simons M et al: Lipomatous hypertrophy of the atrial septum: diagnosis by combined echocardiography and computerized tomography. Am J Cardiol. 54(3):465-6, 1984
                                              17. Prior JT: Lipomatous hypertrophy of cardiac interatrial septum: a lesion resembling hibernoma, lipoblastomatosis and infiltrating lipoma. Arch Pathol. 78:11-5, 1964
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Lipomatous hypertrophy of interatrial septum (LHIS or LHIAS)
                                                        • Synonyms

                                                          • Lipomatous hypertrophy of atrial septum
                                                          • Lipomatous hamartoma
                                                          • Lipomatous hyperplasia
                                                          • Massive fatty deposits
                                                        • Definitions

                                                          • Nonneoplastic deposition of excessive amounts of fat within interatrial septum
                                                            • 1st described in 1964 by JT Prior
                                                          • Not true neoplasm

                                                        IMAGING

                                                        • General Features

                                                          • Imaging Recommendations

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Nuclear Medicine Findings

                                                                    • Echocardiographic Findings

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Coulier B et al: Lipomatous hypertrophy of interatrial septum causing hot spot on 18FDG PET/CT. Diagn Interv Imaging. 100(3):197-8, 2019
                                                                                          2. Rocha RV et al: Adipose tumors of the heart. J Card Surg. 33(8):432-7, 2018
                                                                                          3. Motwani M et al: MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 268(1):26-43, 2013
                                                                                          4. Lee SH et al: Visceral obesity of the heart: extensive lipomatous hypertrophy of interatrial septum. J Cardiovasc Ultrasound. 20(3):161-2, 2012
                                                                                          5. Rigatelli G et al: Anatomo-functional characterization of interatrial septum for catheter-based interventions. Am J Cardiovasc Dis. 1(3):227-35, 2011
                                                                                          6. Pugliatti P et al: Lipomatous hypertrophy of the interatrial septum. Int J Cardiol. 130(2):294-5, 2008
                                                                                          7. Tugcu A et al: Lipomatous hypertrophy of the interatrial septum presenting as an obstructive right atrial mass in a patient with exertional dyspnea. J Am Soc Echocardiogr. 20(11):1319.e3-5, 2007
                                                                                          8. Fan CM et al: Lipomatous hypertrophy of the interatrial septum: increased uptake on FDG PET. AJR Am J Roentgenol. 184(1):339-42, 2005
                                                                                          9. Kuester LB et al: Lipomatous hypertrophy of the interatrial septum: prevalence and features on fusion 18F fluorodeoxyglucose positron emission tomography/CT. Chest. 128(6):3888-93, 2005
                                                                                          10. Heyer CM et al: Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms. Chest. 124(6):2068-73, 2003
                                                                                          11. Iacovoni A et al: [Lipomatous hypertrophy of the interatrial septum: its assessment with TEE, CT and MRI.] G Ital Cardiol. 28(11):1273-7, 1998
                                                                                          12. Meaney JF et al: CT appearance of lipomatous hypertrophy of the interatrial septum. AJR Am J Roentgenol. 168(4):1081-4, 1997
                                                                                          13. Burke AP et al: Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass. Am J Surg Pathol. 20(6):678-85, 1996
                                                                                          14. Shirani J et al: Clinical, electrocardiographic and morphologic features of massive fatty deposits ("lipomatous hypertrophy") in the atrial septum. J Am Coll Cardiol. 22(1):226-38, 1993
                                                                                          15. Lund JT et al: Cardiac masses: assessment by MR imaging. AJR Am J Roentgenol. 152(3):469-73, 1989
                                                                                          16. Simons M et al: Lipomatous hypertrophy of the atrial septum: diagnosis by combined echocardiography and computerized tomography. Am J Cardiol. 54(3):465-6, 1984
                                                                                          17. Prior JT: Lipomatous hypertrophy of cardiac interatrial septum: a lesion resembling hibernoma, lipoblastomatosis and infiltrating lipoma. Arch Pathol. 78:11-5, 1964