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Lipomyelomeningocele
Kevin R. Moore, MD; Usha D. Nagaraj, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Lipomyelomeningocele (LMMC), lipomyelocele (LMC)
              • Synonyms

                • Lipoma with dorsal defect (includes spectrum of LMCs & LMMCs)
                • Lipomyeloschisis

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Meena RK et al: Contiguous diastematomyelia with lipomyelomeningocele in each hemicord-an exceptional case of spinal dysraphism. World Neurosurg. 123:103-7, 2019
                                            2. Wagner KM et al: Surgical management of lipomyelomeningocele in children: challenges and considerations. Surg Neurol Int. 8:63, 2017
                                            3. Goodrich DJ et al: Symptomatic retethering of the spinal cord in postoperative lipomyelomeningocele patients: a meta-analysis. Childs Nerv Syst. 32(1):121-6, 2016
                                            4. Nagaraj UD et al: Differentiating closed versus open spinal dysraphisms on fetal MRI. AJR Am J Roentgenol. 207(6):1316-23, 2016
                                            5. May L et al: Lack of uniformity in the clinical assessment of children with lipomyelomeningocele: a review of the literature and recommendations for the future. Childs Nerv Syst. 29(6):961-70, 2013
                                            6. Segal LS et al: The spectrum of musculoskeletal problems in lipomyelomeningocele. J Child Orthop. 7(6):513-9, 2013
                                            7. Barkovich AJ et al: Pediatric Neuroimaging. 5th ed. Philadelphia: Lippincott Williams & Wilkins. 877-82, 2012
                                            8. Sarris CE et al: Lipomyelomeningocele: pathology, treatment, and outcomes. Neurosurg Focus. 33(4):E3, 2012
                                            9. Rufener SL et al: Congenital spine and spinal cord malformations--pictorial review. AJR Am J Roentgenol. 194(3 Suppl):S26-37, 2010
                                            10. Oi S et al: Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan. J Neurosurg Pediatr. 3(5):412-9, 2009
                                            11. Cochrane DD: Cord untethering for lipomyelomeningocele: expectation after surgery. Neurosurg Focus. 23(2):1-7, 2007
                                            12. Tubbs RS et al: Critical analysis of the Chiari malformation Type I found in children with lipomyelomeningocele. J Neurosurg. 106(3 Suppl):196-200, 2007
                                            13. McNeely PD et al: Ineffectiveness of dietary folic acid supplementation on the incidence of lipomyelomeningocele: pathogenetic implications. J Neurosurg. 100(2):98-100, 2004
                                            14. Rossi A et al: Imaging in spine and spinal cord malformations. Eur J Radiol. 50(2):177-200, 2004
                                            15. Schoenmakers MA et al: Long-term outcome of neurosurgical untethering on neurosegmental motor and ambulation levels. Dev Med Child Neurol. 45(8):551-5, 2003
                                            16. Kim SY et al: Prenatal diagnosis of lipomyelomeningocele. J Ultrasound Med. 19(11):801-5, 2000
                                            17. Tortori-Donati P et al: Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42(7): 471-91, 2000
                                            18. Colak A et al: Recurrent tethering: a common long-term problem after lipomyelomeningocele repair. Pediatr Neurosurg. 29(4):184-90, 1998
                                            19. Chreston J et al: Sonographic detection of lipomyelomeningocele: a retrospective documentation. J Clin Ultrasound. 25(1):50-1, 1997
                                            20. Pierre-Kahn A et al: Congenital lumbosacral lipomas. Childs Nerv Syst. 13(6):298-334; discussion 335, 1997
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Lipomyelomeningocele (LMMC), lipomyelocele (LMC)
                                                        • Synonyms

                                                          • Lipoma with dorsal defect (includes spectrum of LMCs & LMMCs)
                                                          • Lipomyeloschisis

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Ultrasonographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Meena RK et al: Contiguous diastematomyelia with lipomyelomeningocele in each hemicord-an exceptional case of spinal dysraphism. World Neurosurg. 123:103-7, 2019
                                                                                      2. Wagner KM et al: Surgical management of lipomyelomeningocele in children: challenges and considerations. Surg Neurol Int. 8:63, 2017
                                                                                      3. Goodrich DJ et al: Symptomatic retethering of the spinal cord in postoperative lipomyelomeningocele patients: a meta-analysis. Childs Nerv Syst. 32(1):121-6, 2016
                                                                                      4. Nagaraj UD et al: Differentiating closed versus open spinal dysraphisms on fetal MRI. AJR Am J Roentgenol. 207(6):1316-23, 2016
                                                                                      5. May L et al: Lack of uniformity in the clinical assessment of children with lipomyelomeningocele: a review of the literature and recommendations for the future. Childs Nerv Syst. 29(6):961-70, 2013
                                                                                      6. Segal LS et al: The spectrum of musculoskeletal problems in lipomyelomeningocele. J Child Orthop. 7(6):513-9, 2013
                                                                                      7. Barkovich AJ et al: Pediatric Neuroimaging. 5th ed. Philadelphia: Lippincott Williams & Wilkins. 877-82, 2012
                                                                                      8. Sarris CE et al: Lipomyelomeningocele: pathology, treatment, and outcomes. Neurosurg Focus. 33(4):E3, 2012
                                                                                      9. Rufener SL et al: Congenital spine and spinal cord malformations--pictorial review. AJR Am J Roentgenol. 194(3 Suppl):S26-37, 2010
                                                                                      10. Oi S et al: Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan. J Neurosurg Pediatr. 3(5):412-9, 2009
                                                                                      11. Cochrane DD: Cord untethering for lipomyelomeningocele: expectation after surgery. Neurosurg Focus. 23(2):1-7, 2007
                                                                                      12. Tubbs RS et al: Critical analysis of the Chiari malformation Type I found in children with lipomyelomeningocele. J Neurosurg. 106(3 Suppl):196-200, 2007
                                                                                      13. McNeely PD et al: Ineffectiveness of dietary folic acid supplementation on the incidence of lipomyelomeningocele: pathogenetic implications. J Neurosurg. 100(2):98-100, 2004
                                                                                      14. Rossi A et al: Imaging in spine and spinal cord malformations. Eur J Radiol. 50(2):177-200, 2004
                                                                                      15. Schoenmakers MA et al: Long-term outcome of neurosurgical untethering on neurosegmental motor and ambulation levels. Dev Med Child Neurol. 45(8):551-5, 2003
                                                                                      16. Kim SY et al: Prenatal diagnosis of lipomyelomeningocele. J Ultrasound Med. 19(11):801-5, 2000
                                                                                      17. Tortori-Donati P et al: Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42(7): 471-91, 2000
                                                                                      18. Colak A et al: Recurrent tethering: a common long-term problem after lipomyelomeningocele repair. Pediatr Neurosurg. 29(4):184-90, 1998
                                                                                      19. Chreston J et al: Sonographic detection of lipomyelomeningocele: a retrospective documentation. J Clin Ultrasound. 25(1):50-1, 1997
                                                                                      20. Pierre-Kahn A et al: Congenital lumbosacral lipomas. Childs Nerv Syst. 13(6):298-334; discussion 335, 1997