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Lipomyelomeningocele
Usha D. Nagaraj, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Lipomyelomeningocele (LMMC), lipomyelocele (LMC)
            • Synonyms

              • Lipoma with dorsal defect (includes spectrum of LMCs & LMMCs)
              • Lipomyeloschisis

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Goodrich DJ et al: Symptomatic retethering of the spinal cord in postoperative lipomyelomeningocele patients: a meta-analysis. Childs Nerv Syst. 32(1):121-6, 2016
                                          2. Nagaraj UD et al: Differentiating closed versus open spinal dysraphisms on fetal MRI. AJR Am J Roentgenol. 207(6):1316-23, 2016
                                          3. May L et al: Lack of uniformity in the clinical assessment of children with lipomyelomeningocele: a review of the literature and recommendations for the future. Childs Nerv Syst. 29(6):961-70, 2013
                                          4. Segal LS et al: The spectrum of musculoskeletal problems in lipomyelomeningocele. J Child Orthop. 7(6):513-9, 2013
                                          5. Barkovich AJ et al: Pediatric Neuroimaging. 5th ed. Philadelphia: Lippincott Williams & Wilkins. 877-82, 2012
                                          6. Sarris CE et al: Lipomyelomeningocele: pathology, treatment, and outcomes. Neurosurg Focus. 33(4):E3, 2012
                                          7. Rufener SL et al: Congenital spine and spinal cord malformations--pictorial review. AJR Am J Roentgenol. 194(3 Suppl):S26-37, 2010
                                          8. Oi S et al: Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan. J Neurosurg Pediatr. 3(5):412-9, 2009
                                          9. Cochrane DD: Cord untethering for lipomyelomeningocele: expectation after surgery. Neurosurg Focus. 23(2):1-7, 2007
                                          10. Tubbs RS et al: Critical analysis of the Chiari malformation Type I found in children with lipomyelomeningocele. J Neurosurg. 106(3 Suppl):196-200, 2007
                                          11. McNeely PD et al: Ineffectiveness of dietary folic acid supplementation on the incidence of lipomyelomeningocele: pathogenetic implications. J Neurosurg. 100(2):98-100, 2004
                                          12. Rossi A et al: Imaging in spine and spinal cord malformations. Eur J Radiol. 50(2):177-200, 2004
                                          13. Schoenmakers MA et al: Long-term outcome of neurosurgical untethering on neurosegmental motor and ambulation levels. Dev Med Child Neurol. 45(8):551-5, 2003
                                          14. Kim SY et al: Prenatal diagnosis of lipomyelomeningocele. J Ultrasound Med. 19(11):801-5, 2000
                                          15. Tortori-Donati P et al: Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42(7): 471-91, 2000
                                          16. Colak A et al: Recurrent tethering: a common long-term problem after lipomyelomeningocele repair. Pediatr Neurosurg. 29(4):184-90, 1998
                                          17. Chreston J et al: Sonographic detection of lipomyelomeningocele: a retrospective documentation. J Clin Ultrasound. 25(1):50-1, 1997
                                          18. Pierre-Kahn A et al: Congenital lumbosacral lipomas. Childs Nerv Syst. 13(6):298-334; discussion 335, 1997
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Lipomyelomeningocele (LMMC), lipomyelocele (LMC)
                                                    • Synonyms

                                                      • Lipoma with dorsal defect (includes spectrum of LMCs & LMMCs)
                                                      • Lipomyeloschisis

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Goodrich DJ et al: Symptomatic retethering of the spinal cord in postoperative lipomyelomeningocele patients: a meta-analysis. Childs Nerv Syst. 32(1):121-6, 2016
                                                                                  2. Nagaraj UD et al: Differentiating closed versus open spinal dysraphisms on fetal MRI. AJR Am J Roentgenol. 207(6):1316-23, 2016
                                                                                  3. May L et al: Lack of uniformity in the clinical assessment of children with lipomyelomeningocele: a review of the literature and recommendations for the future. Childs Nerv Syst. 29(6):961-70, 2013
                                                                                  4. Segal LS et al: The spectrum of musculoskeletal problems in lipomyelomeningocele. J Child Orthop. 7(6):513-9, 2013
                                                                                  5. Barkovich AJ et al: Pediatric Neuroimaging. 5th ed. Philadelphia: Lippincott Williams & Wilkins. 877-82, 2012
                                                                                  6. Sarris CE et al: Lipomyelomeningocele: pathology, treatment, and outcomes. Neurosurg Focus. 33(4):E3, 2012
                                                                                  7. Rufener SL et al: Congenital spine and spinal cord malformations--pictorial review. AJR Am J Roentgenol. 194(3 Suppl):S26-37, 2010
                                                                                  8. Oi S et al: Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan. J Neurosurg Pediatr. 3(5):412-9, 2009
                                                                                  9. Cochrane DD: Cord untethering for lipomyelomeningocele: expectation after surgery. Neurosurg Focus. 23(2):1-7, 2007
                                                                                  10. Tubbs RS et al: Critical analysis of the Chiari malformation Type I found in children with lipomyelomeningocele. J Neurosurg. 106(3 Suppl):196-200, 2007
                                                                                  11. McNeely PD et al: Ineffectiveness of dietary folic acid supplementation on the incidence of lipomyelomeningocele: pathogenetic implications. J Neurosurg. 100(2):98-100, 2004
                                                                                  12. Rossi A et al: Imaging in spine and spinal cord malformations. Eur J Radiol. 50(2):177-200, 2004
                                                                                  13. Schoenmakers MA et al: Long-term outcome of neurosurgical untethering on neurosegmental motor and ambulation levels. Dev Med Child Neurol. 45(8):551-5, 2003
                                                                                  14. Kim SY et al: Prenatal diagnosis of lipomyelomeningocele. J Ultrasound Med. 19(11):801-5, 2000
                                                                                  15. Tortori-Donati P et al: Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42(7): 471-91, 2000
                                                                                  16. Colak A et al: Recurrent tethering: a common long-term problem after lipomyelomeningocele repair. Pediatr Neurosurg. 29(4):184-90, 1998
                                                                                  17. Chreston J et al: Sonographic detection of lipomyelomeningocele: a retrospective documentation. J Clin Ultrasound. 25(1):50-1, 1997
                                                                                  18. Pierre-Kahn A et al: Congenital lumbosacral lipomas. Childs Nerv Syst. 13(6):298-334; discussion 335, 1997