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Liposarcoma of Head and Neck
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Soft tissue malignancy arising from fat tissue
                • Well-differentiated, intermediate (myxoid), and poorly differentiated types (round cell, pleomorphic, & dedifferentiated)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          • Reporting Tips

                                            Selected References

                                            1. Crowson MG et al: Rare cases of large parapharyngeal lipomas. Am J Otolaryngol. 37(1):54-8, 2016
                                            2. de Bree E et al: Lipomatous tumours of the head and neck: a spectrum of biological behaviour. Eur Arch Otorhinolaryngol. 272(5):1061-77, 2015
                                            3. Kikuchi N et al: Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature. J Laryngol Otol. 129 Suppl 2:S86-90, 2015
                                            4. Gerry D et al: Liposarcoma of the head and neck: analysis of 318 cases with comparison to non-head and neck sites. Head Neck. 36(3):393-400, 2014
                                            5. O'Neill JP et al: Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am. 24(1):67-78, 2013
                                            6. Tejani MA et al: Head and neck sarcomas: a comprehensive cancer center experience. Cancers (Basel). 5(3):890-900, 2013
                                            7. Coca Pelaz A et al: Giant neck liposarcoma with pathological clavicular fracture. Auris Nasus Larynx. 37(3):394-6, 2010
                                            8. Endo M et al: Low-grade dedifferentiated liposarcoma of the neck: magnetic resonance imaging and pathological correlation. J Orthop Sci. 15(1):148-52, 2010
                                            9. Gethin-Jones TL et al: Surgical management of mediastinal liposarcoma extending from hypopharynx to carina: case report. World J Surg Oncol. 8:13, 2010
                                            10. Madge SN et al: Primary orbital liposarcoma. Ophthalmology. 117(3):606-14, 2010
                                            11. Makeieff M et al: Laryngeal dedifferentiated liposarcoma. Eur Arch Otorhinolaryngol. 267(6):991-4, 2010
                                            12. McQueen C et al: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol. 17(1):38-41, 2010
                                            13. Alicandri-Ciufelli M et al: Giant retropharyngeal liposarcoma. ANZ J Surg. 79(6):485-7, 2009
                                            14. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                            15. Huang GW et al: Primary myxoid liposarcoma of the thyroid gland. J Clin Pathol. 62(11):1037-8, 2009
                                            16. Kind M et al: Histology and imaging of soft tissue sarcomas. Eur J Radiol. 72(1):6-15, 2009
                                            17. Mahmood U et al: Atypical lipomatous tumor/well-differentiated liposarcoma of the parotid gland: case report and literature review. Ear Nose Throat J. 88(10):E10-6, 2009
                                            18. Shellenberger TD et al: Sarcomas of the head and neck region. Curr Oncol Rep. 11(2):135-42, 2009
                                            19. Thompson SM et al: Case report: Liposarcoma of the sinonasal tract. Br J Radiol. 82(980):e160-3, 2009
                                            20. Tewfik JN et al: Fluorine-18-deoxyglucose-positron emission tomography imaging with magnetic resonance and computed tomographic correlation in the evaluation of bone and soft-tissue sarcomas: a pictorial essay. Curr Probl Diagn Radiol. 37(4):178-88, 2008
                                            21. Patel SG et al: Soft tissue sarcomas of the head and neck: an update. Am J Otolaryngol. 22(1):2-18, 2001
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Soft tissue malignancy arising from fat tissue
                                                          • Well-differentiated, intermediate (myxoid), and poorly differentiated types (round cell, pleomorphic, & dedifferentiated)

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Image Interpretation Pearls

                                                                                    • Reporting Tips

                                                                                      Selected References

                                                                                      1. Crowson MG et al: Rare cases of large parapharyngeal lipomas. Am J Otolaryngol. 37(1):54-8, 2016
                                                                                      2. de Bree E et al: Lipomatous tumours of the head and neck: a spectrum of biological behaviour. Eur Arch Otorhinolaryngol. 272(5):1061-77, 2015
                                                                                      3. Kikuchi N et al: Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature. J Laryngol Otol. 129 Suppl 2:S86-90, 2015
                                                                                      4. Gerry D et al: Liposarcoma of the head and neck: analysis of 318 cases with comparison to non-head and neck sites. Head Neck. 36(3):393-400, 2014
                                                                                      5. O'Neill JP et al: Head and neck sarcomas: epidemiology, pathology, and management. Neurosurg Clin N Am. 24(1):67-78, 2013
                                                                                      6. Tejani MA et al: Head and neck sarcomas: a comprehensive cancer center experience. Cancers (Basel). 5(3):890-900, 2013
                                                                                      7. Coca Pelaz A et al: Giant neck liposarcoma with pathological clavicular fracture. Auris Nasus Larynx. 37(3):394-6, 2010
                                                                                      8. Endo M et al: Low-grade dedifferentiated liposarcoma of the neck: magnetic resonance imaging and pathological correlation. J Orthop Sci. 15(1):148-52, 2010
                                                                                      9. Gethin-Jones TL et al: Surgical management of mediastinal liposarcoma extending from hypopharynx to carina: case report. World J Surg Oncol. 8:13, 2010
                                                                                      10. Madge SN et al: Primary orbital liposarcoma. Ophthalmology. 117(3):606-14, 2010
                                                                                      11. Makeieff M et al: Laryngeal dedifferentiated liposarcoma. Eur Arch Otorhinolaryngol. 267(6):991-4, 2010
                                                                                      12. McQueen C et al: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol. 17(1):38-41, 2010
                                                                                      13. Alicandri-Ciufelli M et al: Giant retropharyngeal liposarcoma. ANZ J Surg. 79(6):485-7, 2009
                                                                                      14. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                                                                      15. Huang GW et al: Primary myxoid liposarcoma of the thyroid gland. J Clin Pathol. 62(11):1037-8, 2009
                                                                                      16. Kind M et al: Histology and imaging of soft tissue sarcomas. Eur J Radiol. 72(1):6-15, 2009
                                                                                      17. Mahmood U et al: Atypical lipomatous tumor/well-differentiated liposarcoma of the parotid gland: case report and literature review. Ear Nose Throat J. 88(10):E10-6, 2009
                                                                                      18. Shellenberger TD et al: Sarcomas of the head and neck region. Curr Oncol Rep. 11(2):135-42, 2009
                                                                                      19. Thompson SM et al: Case report: Liposarcoma of the sinonasal tract. Br J Radiol. 82(980):e160-3, 2009
                                                                                      20. Tewfik JN et al: Fluorine-18-deoxyglucose-positron emission tomography imaging with magnetic resonance and computed tomographic correlation in the evaluation of bone and soft-tissue sarcomas: a pictorial essay. Curr Probl Diagn Radiol. 37(4):178-88, 2008
                                                                                      21. Patel SG et al: Soft tissue sarcomas of the head and neck: an update. Am J Otolaryngol. 22(1):2-18, 2001