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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Lithium-induced nephropathy
- Lithium nephrotoxicity
Definitions
- Spectrum of functional and structural renal damage caused by lithium ingestion
- Can occur in context of suicide attempts, elevated lithium level, or therapeutic lithium level
- Nephrogenic diabetes insipidus and chronic renal insufficiency are most common presentations
IMAGING
General Features
Imaging Recommendations
MR Findings
Ultrasonographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Anthonissen A et al: An unexpected imaging finding in a CKD patient on lithium therapy. ASN. Published January 2021. Accessed June 2021. https://kidney360.asnjournals.org/content/2/1/180
- Bartoli M et al: MRI features of lithium-induced nephropathy. Diagn Interv Imaging. 100(5):317-8, 2019
- Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
- Di Salvo DN et al: Lithium nephropathy: unique sonographic findings. J Ultrasound Med. 31(4):637-44, 2012
- McKnight RF et al: Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 379(9817):721-8, 2012
- Slaughter A et al: MRI findings in chronic lithium nephropathy: a case report. J Radiol Case Rep. 4(8):15-21, 2010
- van Melick EJ et al: Renal effects of long-term lithium therapy in the elderly: a cross-sectional study. Int J Geriatr Psychiatry. 23(7):685-92, 2008
- Farres MT et al: Chronic lithium nephropathy: MR imaging for diagnosis. Radiology. 229(2):570-4, 2003
- Markowitz GS et al: Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol. 11(8):1439-48, 2000
- Boton R et al: Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis. 10(5):329-45, 1987
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
- Lithium-induced nephropathy
- Lithium nephrotoxicity
Definitions
- Spectrum of functional and structural renal damage caused by lithium ingestion
- Can occur in context of suicide attempts, elevated lithium level, or therapeutic lithium level
- Nephrogenic diabetes insipidus and chronic renal insufficiency are most common presentations
IMAGING
General Features
Imaging Recommendations
MR Findings
Ultrasonographic Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
- Anthonissen A et al: An unexpected imaging finding in a CKD patient on lithium therapy. ASN. Published January 2021. Accessed June 2021. https://kidney360.asnjournals.org/content/2/1/180
- Bartoli M et al: MRI features of lithium-induced nephropathy. Diagn Interv Imaging. 100(5):317-8, 2019
- Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
- Di Salvo DN et al: Lithium nephropathy: unique sonographic findings. J Ultrasound Med. 31(4):637-44, 2012
- McKnight RF et al: Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 379(9817):721-8, 2012
- Slaughter A et al: MRI findings in chronic lithium nephropathy: a case report. J Radiol Case Rep. 4(8):15-21, 2010
- van Melick EJ et al: Renal effects of long-term lithium therapy in the elderly: a cross-sectional study. Int J Geriatr Psychiatry. 23(7):685-92, 2008
- Farres MT et al: Chronic lithium nephropathy: MR imaging for diagnosis. Radiology. 229(2):570-4, 2003
- Markowitz GS et al: Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol. 11(8):1439-48, 2000
- Boton R et al: Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis. 10(5):329-45, 1987
