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Imaging
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Abbreviations
- Pleomorphic lobular carcinoma in situ (pLCIS)
Definitions
- pLCIS: High nuclear grade LCIS, more aggressive subtype of lobular carcinoma in situ (LCIS)
- Lobular neoplasia (LN): Spectrum of atypical lobular hyperplasia and LCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Fasola CE et al: Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast. Breast J. 24(1):66-69, 2018
- Masannat YA et al: Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ. Breast. 38:120-124, 2018
- Savage JL et al: Pleomorphic lobular carcinoma in situ: Imaging features, upgrade rate, and clinical outcomes. AJR Am J Roentgenol. 1-6, 2018
- De Brot M et al: Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review. Breast Cancer Res Treat. 165(2):411-420, 2017
- Ginter PS et al: Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants. Arch Pathol Lab Med. 141(12):1668-1678, 2017
- Giuliano AE et al: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(4):290-303, 2017
- Guo T et al: Pleomorphic lobular carcinoma in situ diagnosed by breast core biopsy: Clinicopathologic features and correlation with subsequent excision. Clin Breast Cancer. ePub, 2017
- Maxwell AJ et al: The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. Breast. 27:109-15, 2016
- Wazir U et al: Pleomorphic lobular carcinoma in situ: Current evidence and a systemic review. Oncol Lett. 12(6):4863-4868, 2016
- Blanco LZ et al: Multinucleation is an objective feature useful in the diagnosis of pleomorphic lobular carcinoma in situ. Am J Clin Pathol. 144(5):722-6, 2015
- Chester R et al: UK national survey of management of breast lobular carcinoma in situ. Ann R Coll Surg Engl. 97(8):574-7, 2015
- Flanagan MR et al: Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management. Ann Surg Oncol. 22(13):4263-9, 2015
- Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
- Jorns J et al: Lobular neoplasia: morphology and management. Arch Pathol Lab Med. 138(10):1344-9, 2014
- Khoury T et al: Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology. 64(7):981-93, 2014
- Meroni S et al: Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy. Eur Radiol. 24(7):1651-8, 2014
- Pieri A et al: Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World J Clin Oncol. 5(3):546-53, 2014
- Blair SL et al: Breast surgeon's survey: no consensus for surgical treatment of pleomorphic lobular carcinoma in situ. Breast J. 19(1):116-8, 2013
- Masannat YA et al: Challenges in the management of pleomorphic lobular carcinoma in situ of the breast. Breast. 22(2):194-6, 2013
- Shin SJ et al: Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ. Hum Pathol. 44(10):1998-2009, 2013
- Murray L et al: Pleomorphic lobular carcinoma in situ: treatment options for a new pathologic entity. Clin Breast Cancer. 12(1):76-9, 2012
- Chivukula M: Pleomorphic lobular carcinoma in situ: A divergent entity with emerging significance. Oncology (Williston Park). 25(4):358, 360, 362, 2011
- Downs-Kelly E et al: Clinical implications of margin involvement by pleomorphic lobular carcinoma in situ. Arch Pathol Lab Med. 135(6):737-43, 2011
- Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
- Brogi E et al: Lobular carcinoma, not only a classic. Breast J. 16 Suppl 1:S10-4, 2010
- Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
- Gao F et al: Clinical importance of histologic grading of lobular carcinoma in situ in breast core needle biopsy specimens: current issues and controversies. Am J Clin Pathol. 133(5):767-71, 2010
- Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
- Chen YY et al: Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol. 33(11):1683-94, 2009
- Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
- Lavoué V et al: Management of lobular neoplasia diagnosed by core needle biopsy: study of 52 biopsies with follow-up surgical excision. Breast. 16(5):533-9, 2007
- Fadare O et al: Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases. Am J Surg Pathol. 30(11):1445-53, 2006
- Mahoney MC et al: Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. AJR Am J Roentgenol. 187(4):949-54, 2006
- Elsheikh TM et al: Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol. 29(4):534-43, 2005
- Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
- Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001
- Pacelli A et al: Outcome of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed by core needle biopsy: clinical and surgical follow-up of 30 cases. Am J Clin Pathol. 116:591-2, 2001
- Sapino A et al: Mammographically detected in situ lobular carcinomas of the breast. Virchows Arch. 436(5):421-30, 2000
- Pleomorphic lobular carcinoma in situ
- Pleomorphic lobular carcinoma in situ
- The Diagnosis of Pleomorphic Lobular Carcinoma In Situ Warrants Complete Excision with Negative Margins
- Clinical and radiological presentation of pleomorphic lobular carcinoma in-situ and its association with invasive malignancy
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Pleomorphic lobular carcinoma in situ (pLCIS)
Definitions
- pLCIS: High nuclear grade LCIS, more aggressive subtype of lobular carcinoma in situ (LCIS)
- Lobular neoplasia (LN): Spectrum of atypical lobular hyperplasia and LCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
- Fasola CE et al: Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast. Breast J. 24(1):66-69, 2018
- Masannat YA et al: Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ. Breast. 38:120-124, 2018
- Savage JL et al: Pleomorphic lobular carcinoma in situ: Imaging features, upgrade rate, and clinical outcomes. AJR Am J Roentgenol. 1-6, 2018
- De Brot M et al: Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review. Breast Cancer Res Treat. 165(2):411-420, 2017
- Ginter PS et al: Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants. Arch Pathol Lab Med. 141(12):1668-1678, 2017
- Giuliano AE et al: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(4):290-303, 2017
- Guo T et al: Pleomorphic lobular carcinoma in situ diagnosed by breast core biopsy: Clinicopathologic features and correlation with subsequent excision. Clin Breast Cancer. ePub, 2017
- Maxwell AJ et al: The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. Breast. 27:109-15, 2016
- Wazir U et al: Pleomorphic lobular carcinoma in situ: Current evidence and a systemic review. Oncol Lett. 12(6):4863-4868, 2016
- Blanco LZ et al: Multinucleation is an objective feature useful in the diagnosis of pleomorphic lobular carcinoma in situ. Am J Clin Pathol. 144(5):722-6, 2015
- Chester R et al: UK national survey of management of breast lobular carcinoma in situ. Ann R Coll Surg Engl. 97(8):574-7, 2015
- Flanagan MR et al: Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management. Ann Surg Oncol. 22(13):4263-9, 2015
- Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
- Jorns J et al: Lobular neoplasia: morphology and management. Arch Pathol Lab Med. 138(10):1344-9, 2014
- Khoury T et al: Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology. 64(7):981-93, 2014
- Meroni S et al: Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy. Eur Radiol. 24(7):1651-8, 2014
- Pieri A et al: Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World J Clin Oncol. 5(3):546-53, 2014
- Blair SL et al: Breast surgeon's survey: no consensus for surgical treatment of pleomorphic lobular carcinoma in situ. Breast J. 19(1):116-8, 2013
- Masannat YA et al: Challenges in the management of pleomorphic lobular carcinoma in situ of the breast. Breast. 22(2):194-6, 2013
- Shin SJ et al: Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ. Hum Pathol. 44(10):1998-2009, 2013
- Murray L et al: Pleomorphic lobular carcinoma in situ: treatment options for a new pathologic entity. Clin Breast Cancer. 12(1):76-9, 2012
- Chivukula M: Pleomorphic lobular carcinoma in situ: A divergent entity with emerging significance. Oncology (Williston Park). 25(4):358, 360, 362, 2011
- Downs-Kelly E et al: Clinical implications of margin involvement by pleomorphic lobular carcinoma in situ. Arch Pathol Lab Med. 135(6):737-43, 2011
- Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
- Brogi E et al: Lobular carcinoma, not only a classic. Breast J. 16 Suppl 1:S10-4, 2010
- Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
- Gao F et al: Clinical importance of histologic grading of lobular carcinoma in situ in breast core needle biopsy specimens: current issues and controversies. Am J Clin Pathol. 133(5):767-71, 2010
- Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
- Chen YY et al: Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol. 33(11):1683-94, 2009
- Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
- Lavoué V et al: Management of lobular neoplasia diagnosed by core needle biopsy: study of 52 biopsies with follow-up surgical excision. Breast. 16(5):533-9, 2007
- Fadare O et al: Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases. Am J Surg Pathol. 30(11):1445-53, 2006
- Mahoney MC et al: Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. AJR Am J Roentgenol. 187(4):949-54, 2006
- Elsheikh TM et al: Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol. 29(4):534-43, 2005
- Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
- Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001
- Pacelli A et al: Outcome of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed by core needle biopsy: clinical and surgical follow-up of 30 cases. Am J Clin Pathol. 116:591-2, 2001
- Sapino A et al: Mammographically detected in situ lobular carcinomas of the breast. Virchows Arch. 436(5):421-30, 2000
- Pleomorphic lobular carcinoma in situ
- Pleomorphic lobular carcinoma in situ
- The Diagnosis of Pleomorphic Lobular Carcinoma In Situ Warrants Complete Excision with Negative Margins
- Clinical and radiological presentation of pleomorphic lobular carcinoma in-situ and its association with invasive malignancy
