pLCIS: High nuclear grade LCIS, more aggressive subtype of lobular carcinoma in situ (LCIS)
Lobular neoplasia (LN): Spectrum of atypical lobular hyperplasia and LCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Fasola CE et al: Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast. Breast J. 24(1):66-69, 2018
Masannat YA et al: Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ. Breast. 38:120-124, 2018
Savage JL et al: Pleomorphic lobular carcinoma in situ: Imaging features, upgrade rate, and clinical outcomes. AJR Am J Roentgenol. 1-6, 2018
De Brot M et al: Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review. Breast Cancer Res Treat. 165(2):411-420, 2017
Ginter PS et al: Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants. Arch Pathol Lab Med. 141(12):1668-1678, 2017
Giuliano AE et al: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(4):290-303, 2017
Guo T et al: Pleomorphic lobular carcinoma in situ diagnosed by breast core biopsy: Clinicopathologic features and correlation with subsequent excision. Clin Breast Cancer. ePub, 2017
Maxwell AJ et al: The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. Breast. 27:109-15, 2016
Wazir U et al: Pleomorphic lobular carcinoma in situ: Current evidence and a systemic review. Oncol Lett. 12(6):4863-4868, 2016
Blanco LZ et al: Multinucleation is an objective feature useful in the diagnosis of pleomorphic lobular carcinoma in situ. Am J Clin Pathol. 144(5):722-6, 2015
Chester R et al: UK national survey of management of breast lobular carcinoma in situ. Ann R Coll Surg Engl. 97(8):574-7, 2015
Flanagan MR et al: Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management. Ann Surg Oncol. 22(13):4263-9, 2015
Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
Jorns J et al: Lobular neoplasia: morphology and management. Arch Pathol Lab Med. 138(10):1344-9, 2014
Khoury T et al: Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology. 64(7):981-93, 2014
Meroni S et al: Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy. Eur Radiol. 24(7):1651-8, 2014
Pieri A et al: Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World J Clin Oncol. 5(3):546-53, 2014
Blair SL et al: Breast surgeon's survey: no consensus for surgical treatment of pleomorphic lobular carcinoma in situ. Breast J. 19(1):116-8, 2013
Masannat YA et al: Challenges in the management of pleomorphic lobular carcinoma in situ of the breast. Breast. 22(2):194-6, 2013
Shin SJ et al: Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ. Hum Pathol. 44(10):1998-2009, 2013
Murray L et al: Pleomorphic lobular carcinoma in situ: treatment options for a new pathologic entity. Clin Breast Cancer. 12(1):76-9, 2012
Chivukula M: Pleomorphic lobular carcinoma in situ: A divergent entity with emerging significance. Oncology (Williston Park). 25(4):358, 360, 362, 2011
Downs-Kelly E et al: Clinical implications of margin involvement by pleomorphic lobular carcinoma in situ. Arch Pathol Lab Med. 135(6):737-43, 2011
Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
Brogi E et al: Lobular carcinoma, not only a classic. Breast J. 16 Suppl 1:S10-4, 2010
Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
Gao F et al: Clinical importance of histologic grading of lobular carcinoma in situ in breast core needle biopsy specimens: current issues and controversies. Am J Clin Pathol. 133(5):767-71, 2010
Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
Chen YY et al: Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol. 33(11):1683-94, 2009
Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
Fadare O et al: Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases. Am J Surg Pathol. 30(11):1445-53, 2006
Mahoney MC et al: Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. AJR Am J Roentgenol. 187(4):949-54, 2006
Elsheikh TM et al: Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol. 29(4):534-43, 2005
Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001
Pacelli A et al: Outcome of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed by core needle biopsy: clinical and surgical follow-up of 30 cases. Am J Clin Pathol. 116:591-2, 2001
Sapino A et al: Mammographically detected in situ lobular carcinomas of the breast. Virchows Arch. 436(5):421-30, 2000
Pleomorphic lobular carcinoma in situ
Pleomorphic lobular carcinoma in situ
The Diagnosis of Pleomorphic Lobular Carcinoma In Situ Warrants Complete Excision with Negative Margins
Clinical and radiological presentation of pleomorphic lobular carcinoma in-situ and its association with invasive malignancy
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Tables
KEY FACTS
Terminology
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TERMINOLOGY
Abbreviations
Pleomorphic lobular carcinoma in situ (pLCIS)
Definitions
pLCIS: High nuclear grade LCIS, more aggressive subtype of lobular carcinoma in situ (LCIS)
Lobular neoplasia (LN): Spectrum of atypical lobular hyperplasia and LCIS
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Fasola CE et al: Characteristics and clinical outcomes of pleomorphic lobular carcinoma in situ of the breast. Breast J. 24(1):66-69, 2018
Masannat YA et al: Pleomorphic LCIS what do we know? A UK multicenter audit of pleomorphic lobular carcinoma in situ. Breast. 38:120-124, 2018
Savage JL et al: Pleomorphic lobular carcinoma in situ: Imaging features, upgrade rate, and clinical outcomes. AJR Am J Roentgenol. 1-6, 2018
De Brot M et al: Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review. Breast Cancer Res Treat. 165(2):411-420, 2017
Ginter PS et al: Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants. Arch Pathol Lab Med. 141(12):1668-1678, 2017
Giuliano AE et al: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67(4):290-303, 2017
Guo T et al: Pleomorphic lobular carcinoma in situ diagnosed by breast core biopsy: Clinicopathologic features and correlation with subsequent excision. Clin Breast Cancer. ePub, 2017
Maxwell AJ et al: The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. Breast. 27:109-15, 2016
Wazir U et al: Pleomorphic lobular carcinoma in situ: Current evidence and a systemic review. Oncol Lett. 12(6):4863-4868, 2016
Blanco LZ et al: Multinucleation is an objective feature useful in the diagnosis of pleomorphic lobular carcinoma in situ. Am J Clin Pathol. 144(5):722-6, 2015
Chester R et al: UK national survey of management of breast lobular carcinoma in situ. Ann R Coll Surg Engl. 97(8):574-7, 2015
Flanagan MR et al: Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management. Ann Surg Oncol. 22(13):4263-9, 2015
Lien HC et al: Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast. Breast Cancer Res Treat. 150(2):447-55, 2015
Jorns J et al: Lobular neoplasia: morphology and management. Arch Pathol Lab Med. 138(10):1344-9, 2014
Khoury T et al: Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology. 64(7):981-93, 2014
Meroni S et al: Underestimation rate of lobular intraepithelial neoplasia in vacuum-assisted breast biopsy. Eur Radiol. 24(7):1651-8, 2014
Pieri A et al: Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World J Clin Oncol. 5(3):546-53, 2014
Blair SL et al: Breast surgeon's survey: no consensus for surgical treatment of pleomorphic lobular carcinoma in situ. Breast J. 19(1):116-8, 2013
Masannat YA et al: Challenges in the management of pleomorphic lobular carcinoma in situ of the breast. Breast. 22(2):194-6, 2013
Shin SJ et al: Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ. Hum Pathol. 44(10):1998-2009, 2013
Murray L et al: Pleomorphic lobular carcinoma in situ: treatment options for a new pathologic entity. Clin Breast Cancer. 12(1):76-9, 2012
Chivukula M: Pleomorphic lobular carcinoma in situ: A divergent entity with emerging significance. Oncology (Williston Park). 25(4):358, 360, 362, 2011
Downs-Kelly E et al: Clinical implications of margin involvement by pleomorphic lobular carcinoma in situ. Arch Pathol Lab Med. 135(6):737-43, 2011
Hussain M et al: Management of lobular carcinoma in-situ and atypical lobular hyperplasia of the breast--a review. Eur J Surg Oncol. 37(4):279-89, 2011
Brogi E et al: Lobular carcinoma, not only a classic. Breast J. 16 Suppl 1:S10-4, 2010
Carder PJ et al: Screen-detected pleomorphic lobular carcinoma in situ (PLCIS): risk of concurrent invasive malignancy following a core biopsy diagnosis. Histopathology. 57(3):472-8, 2010
Gao F et al: Clinical importance of histologic grading of lobular carcinoma in situ in breast core needle biopsy specimens: current issues and controversies. Am J Clin Pathol. 133(5):767-71, 2010
Sullivan ME et al: Lobular carcinoma in situ variants in breast cores: potential for misdiagnosis, upgrade rates at surgical excision, and practical implications. Arch Pathol Lab Med. 134(7):1024-8, 2010
Chen YY et al: Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast. Am J Surg Pathol. 33(11):1683-94, 2009
Chivukula M et al: Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 32(11):1721-6, 2008
Fadare O et al: Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases. Am J Surg Pathol. 30(11):1445-53, 2006
Mahoney MC et al: Lobular neoplasia at 11-gauge vacuum-assisted stereotactic biopsy: correlation with surgical excisional biopsy and mammographic follow-up. AJR Am J Roentgenol. 187(4):949-54, 2006
Elsheikh TM et al: Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature. Am J Surg Pathol. 29(4):534-43, 2005
Sneige N et al: Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol. 15(10):1044-50, 2002
Georgian-Smith D et al: Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol. 176(5):1255-9, 2001
Pacelli A et al: Outcome of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed by core needle biopsy: clinical and surgical follow-up of 30 cases. Am J Clin Pathol. 116:591-2, 2001
Sapino A et al: Mammographically detected in situ lobular carcinomas of the breast. Virchows Arch. 436(5):421-30, 2000
Pleomorphic lobular carcinoma in situ
Pleomorphic lobular carcinoma in situ
The Diagnosis of Pleomorphic Lobular Carcinoma In Situ Warrants Complete Excision with Negative Margins
Clinical and radiological presentation of pleomorphic lobular carcinoma in-situ and its association with invasive malignancy
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