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Localized Fibrous Tumor of the Pleura
Melissa L. Rosado de Christenson, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Localized fibrous tumor of pleura (LFTP)
          • Synonyms

            • Solitary fibrous tumor of pleura (SFTP)
              • Term "solitary" inaccurate; multifocal lesions rarely reported
          • Definitions

            • 2nd most common primary pleural neoplasm
            • < 5% of pleural neoplasms
            • Neoplasms of similar histology reported in lung, mediastinum, pericardium, breast, other organs/locations
            • Term "localized mesothelioma" inaccurate
              • LFTP originates in submesothelial tissues
            • Term "benign fibrous tumor" inaccurate
              • 10-15% of LFTP are malignant

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • FDG PET/CT

                    • Angiographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        • Imaging Follow-Up

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Mendez-Sanchez H et al: Solitary fibrous tumors of the pleura: a clinical-pathological characterization emphasizing changes in lung function. Adv Respir Med. 87(4):247-51, 2019
                                              2. Yagyu H et al: Giant solitary fibrous tumor of pleura presenting both benign and malignant features. Am J Case Rep. 20:1755-9, 2019
                                              3. Raafat E et al: Solitary fibrous tumour of the pleura presenting as a giant intrathoracic mass. BMJ Case Rep. 2017, 2017
                                              4. Keraliya AR et al: Solitary fibrous tumors: 2016 imaging update. Radiol Clin North Am. 54(3):565-79, 2016
                                              5. Zhu Y et al: Solitary fibrous tumors of pleura and lung: report of twelve cases. J Thorac Dis. 5(3):310-3, 2013
                                              6. Lahon B et al: Solitary fibrous tumor of the pleura: outcomes of 157 complete resections in a single center. Ann Thorac Surg. 94(2):394-400, 2012
                                              7. Lococo F et al: Malignant solitary fibrous tumors of the pleura: retrospective review of a multicenter series. J Thorac Oncol. 7(11):1698-706, 2012
                                              8. Guo W et al: Retrospective analysis for thirty-nine patients with solitary fibrous tumor of pleura and review of the literature. World J Surg Oncol. 9:134, 2011
                                              9. Song SW et al: Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura. Jpn J Radiol. 28(8):602-8, 2010
                                              10. Cardinale L et al: Fibrous tumour of the pleura (SFTP): a proteiform disease. Clinical, histological and atypical radiological patterns selected among our cases. Radiol Med. 114(2):204-15, 2009
                                              11. Usami N et al: Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. J Thorac Oncol. 2(12):1124-5, 2007
                                              12. Hara M et al: F-18 FDG uptake in a malignant localized fibrous tumor of the pleura. J Thorac Imaging. 20(2):118-9, 2005
                                              13. Lee SC et al: Solitary fibrous tumors of the pleura: clinical, radiological, surgical and pathological evaluation. Eur J Surg Oncol. 31(1):84-7, 2005
                                              14. Mitchell JD: Solitary fibrous tumor of the pleura. Semin Thorac Cardiovasc Surg. 15(3):305-9, 2003
                                              15. Rosado-de-Christenson ML et al: Localized fibrous tumor of the pleura. Radiographics. 23(3):759-83, 2003
                                              16. de Perrot M et al: Solitary fibrous tumors of the pleura. Ann Thorac Surg. 74(1):285-93, 2002
                                              17. Tateishi U et al: Solitary fibrous tumor of the pleura: MR appearance and enhancement pattern. J Comput Assist Tomogr. 26(2):174-9, 2002
                                              18. England DM et al: Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 13:640-58, 1989
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Localized fibrous tumor of pleura (LFTP)
                                                      • Synonyms

                                                        • Solitary fibrous tumor of pleura (SFTP)
                                                          • Term "solitary" inaccurate; multifocal lesions rarely reported
                                                      • Definitions

                                                        • 2nd most common primary pleural neoplasm
                                                        • < 5% of pleural neoplasms
                                                        • Neoplasms of similar histology reported in lung, mediastinum, pericardium, breast, other organs/locations
                                                        • Term "localized mesothelioma" inaccurate
                                                          • LFTP originates in submesothelial tissues
                                                        • Term "benign fibrous tumor" inaccurate
                                                          • 10-15% of LFTP are malignant

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • FDG PET/CT

                                                                • Angiographic Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    • Imaging Follow-Up

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Mendez-Sanchez H et al: Solitary fibrous tumors of the pleura: a clinical-pathological characterization emphasizing changes in lung function. Adv Respir Med. 87(4):247-51, 2019
                                                                                          2. Yagyu H et al: Giant solitary fibrous tumor of pleura presenting both benign and malignant features. Am J Case Rep. 20:1755-9, 2019
                                                                                          3. Raafat E et al: Solitary fibrous tumour of the pleura presenting as a giant intrathoracic mass. BMJ Case Rep. 2017, 2017
                                                                                          4. Keraliya AR et al: Solitary fibrous tumors: 2016 imaging update. Radiol Clin North Am. 54(3):565-79, 2016
                                                                                          5. Zhu Y et al: Solitary fibrous tumors of pleura and lung: report of twelve cases. J Thorac Dis. 5(3):310-3, 2013
                                                                                          6. Lahon B et al: Solitary fibrous tumor of the pleura: outcomes of 157 complete resections in a single center. Ann Thorac Surg. 94(2):394-400, 2012
                                                                                          7. Lococo F et al: Malignant solitary fibrous tumors of the pleura: retrospective review of a multicenter series. J Thorac Oncol. 7(11):1698-706, 2012
                                                                                          8. Guo W et al: Retrospective analysis for thirty-nine patients with solitary fibrous tumor of pleura and review of the literature. World J Surg Oncol. 9:134, 2011
                                                                                          9. Song SW et al: Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura. Jpn J Radiol. 28(8):602-8, 2010
                                                                                          10. Cardinale L et al: Fibrous tumour of the pleura (SFTP): a proteiform disease. Clinical, histological and atypical radiological patterns selected among our cases. Radiol Med. 114(2):204-15, 2009
                                                                                          11. Usami N et al: Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. J Thorac Oncol. 2(12):1124-5, 2007
                                                                                          12. Hara M et al: F-18 FDG uptake in a malignant localized fibrous tumor of the pleura. J Thorac Imaging. 20(2):118-9, 2005
                                                                                          13. Lee SC et al: Solitary fibrous tumors of the pleura: clinical, radiological, surgical and pathological evaluation. Eur J Surg Oncol. 31(1):84-7, 2005
                                                                                          14. Mitchell JD: Solitary fibrous tumor of the pleura. Semin Thorac Cardiovasc Surg. 15(3):305-9, 2003
                                                                                          15. Rosado-de-Christenson ML et al: Localized fibrous tumor of the pleura. Radiographics. 23(3):759-83, 2003
                                                                                          16. de Perrot M et al: Solitary fibrous tumors of the pleura. Ann Thorac Surg. 74(1):285-93, 2002
                                                                                          17. Tateishi U et al: Solitary fibrous tumor of the pleura: MR appearance and enhancement pattern. J Comput Assist Tomogr. 26(2):174-9, 2002
                                                                                          18. England DM et al: Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. 13:640-58, 1989