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Low-Grade Central Osteosarcoma
Behrang Amini, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Low-grade central osteosarcoma (LGCOS)
          • Synonyms

            • Well-differentiated intramedullary osteosarcoma, well-differentiated intraosseous osteosarcoma
          • Definitions

            • Low-grade, malignant, bone-forming neoplasm originating in intramedullary cavity and consisting of fibroblastic tumor cells and well-formed, neoplastic, bony trabeculae

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Yoshida A et al: Low-grade central osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 400-2, 2020
                                        2. He X et al: Consistent amplification of FRS2 and MDM2 in low-grade osteosarcoma: a genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol. 42(9):1143-55, 2018
                                        3. Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
                                        4. Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
                                        5. Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
                                        6. Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
                                        7. Kenan S et al: Dedifferentiated high-grade osteosarcoma originating from low-grade central osteosarcoma of the fibula. Skeletal Radiol. 36(4):347-51, 2007
                                        8. Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
                                        9. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                        10. Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
                                        11. Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Low-grade central osteosarcoma (LGCOS)
                                                • Synonyms

                                                  • Well-differentiated intramedullary osteosarcoma, well-differentiated intraosseous osteosarcoma
                                                • Definitions

                                                  • Low-grade, malignant, bone-forming neoplasm originating in intramedullary cavity and consisting of fibroblastic tumor cells and well-formed, neoplastic, bony trabeculae

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Nuclear Medicine Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Yoshida A et al: Low-grade central osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 400-2, 2020
                                                                              2. He X et al: Consistent amplification of FRS2 and MDM2 in low-grade osteosarcoma: a genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol. 42(9):1143-55, 2018
                                                                              3. Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
                                                                              4. Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
                                                                              5. Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
                                                                              6. Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
                                                                              7. Kenan S et al: Dedifferentiated high-grade osteosarcoma originating from low-grade central osteosarcoma of the fibula. Skeletal Radiol. 36(4):347-51, 2007
                                                                              8. Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
                                                                              9. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                                                              10. Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
                                                                              11. Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990