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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- Low-grade central osteosarcoma (LGCOS)
Synonyms
- Well-differentiated intramedullary osteosarcoma, well-differentiated intraosseous osteosarcoma
Definitions
- Low-grade, malignant, bone-forming neoplasm originating in intramedullary cavity and consisting of fibroblastic tumor cells and well-formed, neoplastic, bony trabeculae
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Yoshida A et al: Low-grade central osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 400-2, 2020
- He X et al: Consistent amplification of FRS2 and MDM2 in low-grade osteosarcoma: a genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol. 42(9):1143-55, 2018
- Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
- Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
- Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
- Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
- Kenan S et al: Dedifferentiated high-grade osteosarcoma originating from low-grade central osteosarcoma of the fibula. Skeletal Radiol. 36(4):347-51, 2007
- Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
- Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
- Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
- Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990
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References
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Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
TERMINOLOGY
Abbreviations
- Low-grade central osteosarcoma (LGCOS)
Synonyms
- Well-differentiated intramedullary osteosarcoma, well-differentiated intraosseous osteosarcoma
Definitions
- Low-grade, malignant, bone-forming neoplasm originating in intramedullary cavity and consisting of fibroblastic tumor cells and well-formed, neoplastic, bony trabeculae
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Yoshida A et al: Low-grade central osteosarcoma. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 400-2, 2020
- He X et al: Consistent amplification of FRS2 and MDM2 in low-grade osteosarcoma: a genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol. 42(9):1143-55, 2018
- Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
- Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
- Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
- Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
- Kenan S et al: Dedifferentiated high-grade osteosarcoma originating from low-grade central osteosarcoma of the fibula. Skeletal Radiol. 36(4):347-51, 2007
- Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
- Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
- Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
- Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990
