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Low-Grade Intraosseous Osteosarcoma
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Synonyms

            • Low-grade central osteosarcoma, well-differentiated intramedullary osteosarcoma, sclerosing osteosarcoma
          • Definitions

            • Low-grade osteosarcoma arising within medullary cavity

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
                                      2. Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
                                      3. Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
                                      4. Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
                                      5. Inwards CY et al: Low grade central osteosarcoma. In Fletcher CDM et al. World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 275-6, 2002
                                      6. Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
                                      7. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                      8. Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
                                      9. Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Synonyms

                                                • Low-grade central osteosarcoma, well-differentiated intramedullary osteosarcoma, sclerosing osteosarcoma
                                              • Definitions

                                                • Low-grade osteosarcoma arising within medullary cavity

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Gilg MM et al: Central low-grade osteosarcoma with an unusual localization in the diaphysis of a 12-year old patient. Radiol Oncol. 47(2):192-6, 2013
                                                                          2. Yarmish G et al: Imaging characteristics of primary osteosarcoma: nonconventional subtypes. Radiographics. 30(6):1653-72, 2010
                                                                          3. Sailor J et al: Low-grade intramedullary osteosarcoma of the tibia presenting as an intracortical lesion. Orthopedics. 31(7):714, 2008
                                                                          4. Steiner GC et al: Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. Ultrastruct Pathol. 30(4):293-9, 2006
                                                                          5. Inwards CY et al: Low grade central osteosarcoma. In Fletcher CDM et al. World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 275-6, 2002
                                                                          6. Andresen KJ et al: Imaging features of low-grade central osteosarcoma of the long bones and pelvis. Skeletal Radiol. 33(7):373-9, 2004
                                                                          7. Murphey MD et al: The many faces of osteosarcoma. Radiographics. 17(5):1205-31, 1997
                                                                          8. Bertoni F et al: Osteosarcoma. Low-grade intraosseous-type osteosarcoma, histologically resembling parosteal osteosarcoma, fibrous dysplasia, and desmoplastic fibroma. Cancer. 71(2):338-45, 1993
                                                                          9. Kurt AM et al: Low-grade intraosseous osteosarcoma. Cancer. 65(6):1418-28, 1990