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Lung Carcinoma
Leif Jensen, MD
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8

OVERVIEW

  • General Comments

    • Classification

      PATHOLOGY

      • Routes of Spread

        • General Features

          • Gross Pathology & Surgical Features

            • Microscopic Features

              IMAGING FINDINGS

              • Detection

                • Staging

                  • Restaging

                    CLINICAL ISSUES

                    • Presentation

                      • Cancer Natural History & Prognosis

                        • Treatment Options

                          REPORTING CHECKLIST

                          • T Staging

                            • N Staging

                              • M Staging

                                • Identify Lesions Amenable to Biopsy

                                  • Pearls

                                    Selected References

                                    1. Carter BW et al: Revisions to the TNM staging of lung cancer: rationale, significance, and clinical application. Radiographics. 38(2):374-91, 2018
                                    2. Carter BW et al: Screening for lung cancer: lexicon for communicating with health care providers. AJR Am J Roentgenol. 210(3):473-9, 2018
                                    3. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                    4. Hirsch FR et al: Lung cancer: current therapies and new targeted treatments. Lancet. 389(10066):299-311, 2017
                                    5. Sheikhbahaei S et al: The value of FDG PET/CT in treatment response assessment, follow-up, and surveillance of lung cancer. AJR Am J Roentgenol. 208(2):420-33, 2017
                                    6. Detterbeck FC et al: The eighth edition lung cancer stage classification. Chest. 151(1):193-203, 2017
                                    7. Detterbeck FC et al: The IASLC lung cancer staging project: background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 11(5):666-80, 2016
                                    8. Goldstraw P et al: The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11(1):39-51, 2016
                                    9. Nicholson AG et al: The International Association for the Study of Lung Cancer Lung Cancer staging project: proposals for the revision of the clinical and pathologic staging of small cell lung cancer in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol. 11(3):300-11, 2016
                                    10. Kanaji N et al: Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 5(3):197-223, 2014
                                    11. Almeida FA et al: Initial evaluation of the nonsmall cell lung cancer patient: diagnosis and staging. Curr Opin Pulm Med. 16(4):307-14, 2010
                                    12. Terasaki H et al: Lung adenocarcinoma, mixed subtype: histopathologic basis for high-resolution computed tomography findings. J Thorac Imaging. 26(1):74-81, 2010
                                    13. Volterrani L et al: MSCT multi-criteria: a novel approach in assessment of mediastinal lymph node metastases in non-small cell lung cancer. Eur J Radiol. 26(1):74-81, 2010
                                    14. Hicks RJ: Role of 18F-FDG PET in assessment of response in non-small cell lung cancer. J Nucl Med. 50 Suppl 1:31S-42S, 2009
                                    15. Wang J et al: Tumor response in patients with advanced non-small cell lung cancer: perfusion CT evaluation of chemotherapy and radiation therapy. AJR Am J Roentgenol. 193(4):1090-6, 2009
                                    16. Gould MK et al: Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132(3 Suppl):108S-130S, 2007
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    OVERVIEW

                                    • General Comments

                                      • Classification

                                        PATHOLOGY

                                        • Routes of Spread

                                          • General Features

                                            • Gross Pathology & Surgical Features

                                              • Microscopic Features

                                                IMAGING FINDINGS

                                                • Detection

                                                  • Staging

                                                    • Restaging

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Cancer Natural History & Prognosis

                                                          • Treatment Options

                                                            REPORTING CHECKLIST

                                                            • T Staging

                                                              • N Staging

                                                                • M Staging

                                                                  • Identify Lesions Amenable to Biopsy

                                                                    • Pearls

                                                                      Selected References

                                                                      1. Carter BW et al: Revisions to the TNM staging of lung cancer: rationale, significance, and clinical application. Radiographics. 38(2):374-91, 2018
                                                                      2. Carter BW et al: Screening for lung cancer: lexicon for communicating with health care providers. AJR Am J Roentgenol. 210(3):473-9, 2018
                                                                      3. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                                                      4. Hirsch FR et al: Lung cancer: current therapies and new targeted treatments. Lancet. 389(10066):299-311, 2017
                                                                      5. Sheikhbahaei S et al: The value of FDG PET/CT in treatment response assessment, follow-up, and surveillance of lung cancer. AJR Am J Roentgenol. 208(2):420-33, 2017
                                                                      6. Detterbeck FC et al: The eighth edition lung cancer stage classification. Chest. 151(1):193-203, 2017
                                                                      7. Detterbeck FC et al: The IASLC lung cancer staging project: background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol. 11(5):666-80, 2016
                                                                      8. Goldstraw P et al: The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11(1):39-51, 2016
                                                                      9. Nicholson AG et al: The International Association for the Study of Lung Cancer Lung Cancer staging project: proposals for the revision of the clinical and pathologic staging of small cell lung cancer in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol. 11(3):300-11, 2016
                                                                      10. Kanaji N et al: Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 5(3):197-223, 2014
                                                                      11. Almeida FA et al: Initial evaluation of the nonsmall cell lung cancer patient: diagnosis and staging. Curr Opin Pulm Med. 16(4):307-14, 2010
                                                                      12. Terasaki H et al: Lung adenocarcinoma, mixed subtype: histopathologic basis for high-resolution computed tomography findings. J Thorac Imaging. 26(1):74-81, 2010
                                                                      13. Volterrani L et al: MSCT multi-criteria: a novel approach in assessment of mediastinal lymph node metastases in non-small cell lung cancer. Eur J Radiol. 26(1):74-81, 2010
                                                                      14. Hicks RJ: Role of 18F-FDG PET in assessment of response in non-small cell lung cancer. J Nucl Med. 50 Suppl 1:31S-42S, 2009
                                                                      15. Wang J et al: Tumor response in patients with advanced non-small cell lung cancer: perfusion CT evaluation of chemotherapy and radiation therapy. AJR Am J Roentgenol. 193(4):1090-6, 2009
                                                                      16. Gould MK et al: Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132(3 Suppl):108S-130S, 2007