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Lung Development
Melissa L. Rosado-de-Christenson, MD, FACR
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GENERAL CONCEPTS

  • Overview of Lung Development

    • Concurrent Developmental Processes

      • Developmental Stages

        EMBRYONIC STAGE (26 DAYS to 6 WEEKS)

        • Laryngotracheal Groove

          • Respiratory Diverticulum or Lung Bud

            • Tracheal Bud

              • Tracheoesophageal Septum

                • Primary Bronchial Buds and Branches

                  PSEUDOGLANDULAR STAGE (6-16 WEEKS)

                  • Microscopic Morphology

                    • Important Events

                      • Physiologic Implications

                        CANALICULAR STAGE (16-28 Weeks)

                        • Microscopic Morphology

                          • Important Events

                            • Physiologic Implications

                              SACCULAR STAGE (28-36 WEEKS)

                              • Microscopic Morphology

                                • Important Events

                                  • Physiologic Implications

                                    ALVEOLAR STAGE (36 WEEKS to 8 YEARS)

                                    • Microscopic Morphology

                                      • Important Events

                                        • Physiologic Implications

                                          IMPORTANT FACTORS FOR NORMAL PRENATAL LUNG DEVELOPMENT

                                          • Volume Requirements

                                            • Circulatory Requirements

                                              NEONATAL LUNG

                                              • Clearance of Retained Fluid

                                                • 1st Breath

                                                  • Postnatal Lung Development

                                                    DISORDERS OF LUNG IMMATURITY

                                                    • Retained Fetal Lung Fluid Syndrome

                                                      • Respiratory Distress Syndrome

                                                        • Central Tracheobronchial Tree

                                                          DEVELOPMENTAL DISORDERS

                                                          • Abnormal Tracheoesophageal Development

                                                            • Abnormalities of Foregut Budding

                                                              • Abnormalities of Distal Airway Development

                                                                Selected References

                                                                1. Chowdhury MM et al: Imaging of congenital lung malformations. Semin Pediatr Surg. 24(4):168-75, 2015
                                                                2. Pramanik AK et al: Neonatal respiratory distress: a practical approach to its diagnosis and management. Pediatr Clin North Am. 62(2):453-69, 2015
                                                                3. Reuter S et al: Respiratory distress in the newborn. Pediatr Rev. 35(10):417-28; quiz 429, 2014
                                                                4. Edwards MO et al: Respiratory distress of the term newborn infant. Paediatr Respir Rev. 14(1):29-36; quiz 36-7, 2013
                                                                5. Moore KL, Persaud TVN: The Developing Human. Clinically Oriented Embryology, 7th ed. Philadelphia, Saunders, 2003.
                                                                Related Anatomy
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                                                                Related Differential Diagnoses
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                                                                References
                                                                Tables

                                                                Tables

                                                                GENERAL CONCEPTS

                                                                • Overview of Lung Development

                                                                  • Concurrent Developmental Processes

                                                                    • Developmental Stages

                                                                      EMBRYONIC STAGE (26 DAYS to 6 WEEKS)

                                                                      • Laryngotracheal Groove

                                                                        • Respiratory Diverticulum or Lung Bud

                                                                          • Tracheal Bud

                                                                            • Tracheoesophageal Septum

                                                                              • Primary Bronchial Buds and Branches

                                                                                PSEUDOGLANDULAR STAGE (6-16 WEEKS)

                                                                                • Microscopic Morphology

                                                                                  • Important Events

                                                                                    • Physiologic Implications

                                                                                      CANALICULAR STAGE (16-28 Weeks)

                                                                                      • Microscopic Morphology

                                                                                        • Important Events

                                                                                          • Physiologic Implications

                                                                                            SACCULAR STAGE (28-36 WEEKS)

                                                                                            • Microscopic Morphology

                                                                                              • Important Events

                                                                                                • Physiologic Implications

                                                                                                  ALVEOLAR STAGE (36 WEEKS to 8 YEARS)

                                                                                                  • Microscopic Morphology

                                                                                                    • Important Events

                                                                                                      • Physiologic Implications

                                                                                                        IMPORTANT FACTORS FOR NORMAL PRENATAL LUNG DEVELOPMENT

                                                                                                        • Volume Requirements

                                                                                                          • Circulatory Requirements

                                                                                                            NEONATAL LUNG

                                                                                                            • Clearance of Retained Fluid

                                                                                                              • 1st Breath

                                                                                                                • Postnatal Lung Development

                                                                                                                  DISORDERS OF LUNG IMMATURITY

                                                                                                                  • Retained Fetal Lung Fluid Syndrome

                                                                                                                    • Respiratory Distress Syndrome

                                                                                                                      • Central Tracheobronchial Tree

                                                                                                                        DEVELOPMENTAL DISORDERS

                                                                                                                        • Abnormal Tracheoesophageal Development

                                                                                                                          • Abnormalities of Foregut Budding

                                                                                                                            • Abnormalities of Distal Airway Development

                                                                                                                              Selected References

                                                                                                                              1. Chowdhury MM et al: Imaging of congenital lung malformations. Semin Pediatr Surg. 24(4):168-75, 2015
                                                                                                                              2. Pramanik AK et al: Neonatal respiratory distress: a practical approach to its diagnosis and management. Pediatr Clin North Am. 62(2):453-69, 2015
                                                                                                                              3. Reuter S et al: Respiratory distress in the newborn. Pediatr Rev. 35(10):417-28; quiz 429, 2014
                                                                                                                              4. Edwards MO et al: Respiratory distress of the term newborn infant. Paediatr Respir Rev. 14(1):29-36; quiz 36-7, 2013
                                                                                                                              5. Moore KL, Persaud TVN: The Developing Human. Clinically Oriented Embryology, 7th ed. Philadelphia, Saunders, 2003.