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Lyme Disease
Miral D. Jhaveri, MD; Laurie A. Loevner, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Lyme disease (LD), Lyme neuroborreliosis (LNB)
            • Definitions

              • Multisystem inflammatory disease
                • Caused by spirochete Borrelia burgdorferi (different subspecies in Europe)
                • Transmitted by hard-bodied tick bite

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Hansen K et al: Lyme neuroborreliosis. Handb Clin Neurol. 115:559-75, 2013
                                      2. Akgoz A et al: Imaging of rickettsial, spirochetal, and parasitic infections. Neuroimaging Clin N Am. 22(4):633-57, 2012
                                      3. Agarwal R et al: Neuro-lyme disease: MR imaging findings. Radiology. 253(1):167-73, 2009
                                      4. Hildenbrand P et al: Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol. 30(6):1079-87, 2009
                                      5. Kalina P et al: Lyme disease of the brainstem. Neuroradiology. 47(12):903-7, 2005
                                      6. Ustymowicz A et al: Proton MR spectroscopy in neuroborreliosis: a preliminary study. Neuroradiology. 46(1):26-30, 2004
                                      7. Tarasów E et al: [Neuroborreliosis: CT and MRI findings in 14 cases. Preliminary communication.] Neurol Neurochir Pol. 35(5):803-13, 2001
                                      8. Fernandez RE et al: Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol. 11(3):479-81, 1990
                                      9. Rafto SE et al: Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T. AJNR Am J Neuroradiol. 11(3):482-4, 1990
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Lyme disease (LD), Lyme neuroborreliosis (LNB)
                                                • Definitions

                                                  • Multisystem inflammatory disease
                                                    • Caused by spirochete Borrelia burgdorferi (different subspecies in Europe)
                                                    • Transmitted by hard-bodied tick bite

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Hansen K et al: Lyme neuroborreliosis. Handb Clin Neurol. 115:559-75, 2013
                                                                          2. Akgoz A et al: Imaging of rickettsial, spirochetal, and parasitic infections. Neuroimaging Clin N Am. 22(4):633-57, 2012
                                                                          3. Agarwal R et al: Neuro-lyme disease: MR imaging findings. Radiology. 253(1):167-73, 2009
                                                                          4. Hildenbrand P et al: Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol. 30(6):1079-87, 2009
                                                                          5. Kalina P et al: Lyme disease of the brainstem. Neuroradiology. 47(12):903-7, 2005
                                                                          6. Ustymowicz A et al: Proton MR spectroscopy in neuroborreliosis: a preliminary study. Neuroradiology. 46(1):26-30, 2004
                                                                          7. Tarasów E et al: [Neuroborreliosis: CT and MRI findings in 14 cases. Preliminary communication.] Neurol Neurochir Pol. 35(5):803-13, 2001
                                                                          8. Fernandez RE et al: Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol. 11(3):479-81, 1990
                                                                          9. Rafto SE et al: Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T. AJNR Am J Neuroradiol. 11(3):482-4, 1990