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Brain
Diagnosis
Pathology-Based Diagnoses
Infectious, Inflammatory, and Demyelinating Disease
Acquired Infections
Lyme Disease
Lyme Disease
Miral D. Jhaveri, MD, MBA
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Lyme disease (LD), Lyme neuroborreliosis (LNB)
Definitions
Multisystem inflammatory disease
Caused by
Borrelia burgdorferi
(USA)
Transmitted by hard-shelled tick bite
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Hagberg L: Diagnosis of Lyme neuroborreliosis. Infect Dis (Lond). 1-2, 2019
Halperin JJ: A neurologist's view of Lyme disease and other tick-borne infections. Semin Neurol. 39(4):440-7, 2019
Halperin JJ: Lyme neuroborreliosis. Curr Opin Infect Dis. 32(3):259-64, 2019
Halperin JJ: Neuroborreliosis. Neurol Clin. 36(4):821-30, 2018
Hansen K et al: Lyme neuroborreliosis. Handb Clin Neurol. 115:559-75, 2013
Akgoz A et al: Imaging of rickettsial, spirochetal, and parasitic infections. Neuroimaging Clin N Am. 22(4):633-57, 2012
Agarwal R et al: Neuro-lyme disease: MR imaging findings. Radiology. 253(1):167-73, 2009
Hildenbrand P et al: Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol. 30(6):1079-87, 2009
Kalina P et al: Lyme disease of the brainstem. Neuroradiology. 47(12):903-7, 2005
Ustymowicz A et al: Proton MR spectroscopy in neuroborreliosis: a preliminary study. Neuroradiology. 46(1):26-30, 2004
Tarasów E et al: [Neuroborreliosis: CT and MRI findings in 14 cases. Preliminary communication.] Neurol Neurochir Pol. 35(5):803-13, 2001
Fernandez RE et al: Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol. 11(3):479-81, 1990
Rafto SE et al: Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T. AJNR Am J Neuroradiol. 11(3):482-4, 1990
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Lyme disease (LD), Lyme neuroborreliosis (LNB)
Definitions
Multisystem inflammatory disease
Caused by
Borrelia burgdorferi
(USA)
Transmitted by hard-shelled tick bite
IMAGING
General Features
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Hagberg L: Diagnosis of Lyme neuroborreliosis. Infect Dis (Lond). 1-2, 2019
Halperin JJ: A neurologist's view of Lyme disease and other tick-borne infections. Semin Neurol. 39(4):440-7, 2019
Halperin JJ: Lyme neuroborreliosis. Curr Opin Infect Dis. 32(3):259-64, 2019
Halperin JJ: Neuroborreliosis. Neurol Clin. 36(4):821-30, 2018
Hansen K et al: Lyme neuroborreliosis. Handb Clin Neurol. 115:559-75, 2013
Akgoz A et al: Imaging of rickettsial, spirochetal, and parasitic infections. Neuroimaging Clin N Am. 22(4):633-57, 2012
Agarwal R et al: Neuro-lyme disease: MR imaging findings. Radiology. 253(1):167-73, 2009
Hildenbrand P et al: Lyme neuroborreliosis: manifestations of a rapidly emerging zoonosis. AJNR Am J Neuroradiol. 30(6):1079-87, 2009
Kalina P et al: Lyme disease of the brainstem. Neuroradiology. 47(12):903-7, 2005
Ustymowicz A et al: Proton MR spectroscopy in neuroborreliosis: a preliminary study. Neuroradiology. 46(1):26-30, 2004
Tarasów E et al: [Neuroborreliosis: CT and MRI findings in 14 cases. Preliminary communication.] Neurol Neurochir Pol. 35(5):803-13, 2001
Fernandez RE et al: Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol. 11(3):479-81, 1990
Rafto SE et al: Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T. AJNR Am J Neuroradiol. 11(3):482-4, 1990
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