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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Lymphangitic carcinomatosis (LC)
Synonyms
- Lymphangitic spread
- Interlobular interstitium = interlobular septa
- Thick interlobular interstitium = septal lines = interlobular septal thickening
Definitions
- Tumor infiltration of lymphatic channels from tumor emboli (common) or direct retrograde spread from affected hilar lymph nodes
- LC results primarily from adenocarcinomas
- Lung
- Breast
- Other: Stomach, colon, pancreas, prostate
- Involvement of lymphatic channels within interlobular and subpleural interstitium (i.e., peripheral interstitium) &/or central lymphatic channels within bronchovascular and centrilobular interstitium (i.e., axial interstitium)
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Diagnosis
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Charest M et al: Prognostic implication of the lymphangitic carcinomatosis pattern on perfusion lung scan. Can Assoc Radiol J. 63(4):294-303, 2012
- Prakash P et al: FDG PET/CT in assessment of pulmonary lymphangitic carcinomatosis. AJR Am J Roentgenol. 194(1):231-6, 2010
- Castañer E et al: Diseases affecting the peribronchovascular interstitium: CT findings and pathologic correlation. Curr Probl Diagn Radiol. 34(2):63-75, 2005
- Digumarthy SR et al: Fluorodeoxyglucose positron emission tomography pattern of pulmonary lymphangitic carcinomatosis. J Comput Assist Tomogr. 29(3):346-9, 2005
- Johkoh T et al: CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests. AJR Am J Roentgenol. 158(6):1217-22, 1992
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Lymphangitic carcinomatosis (LC)
Synonyms
- Lymphangitic spread
- Interlobular interstitium = interlobular septa
- Thick interlobular interstitium = septal lines = interlobular septal thickening
Definitions
- Tumor infiltration of lymphatic channels from tumor emboli (common) or direct retrograde spread from affected hilar lymph nodes
- LC results primarily from adenocarcinomas
- Lung
- Breast
- Other: Stomach, colon, pancreas, prostate
- Involvement of lymphatic channels within interlobular and subpleural interstitium (i.e., peripheral interstitium) &/or central lymphatic channels within bronchovascular and centrilobular interstitium (i.e., axial interstitium)
IMAGING
General Features
Radiographic Findings
CT Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Diagnosis
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
- Charest M et al: Prognostic implication of the lymphangitic carcinomatosis pattern on perfusion lung scan. Can Assoc Radiol J. 63(4):294-303, 2012
- Prakash P et al: FDG PET/CT in assessment of pulmonary lymphangitic carcinomatosis. AJR Am J Roentgenol. 194(1):231-6, 2010
- Castañer E et al: Diseases affecting the peribronchovascular interstitium: CT findings and pathologic correlation. Curr Probl Diagn Radiol. 34(2):63-75, 2005
- Digumarthy SR et al: Fluorodeoxyglucose positron emission tomography pattern of pulmonary lymphangitic carcinomatosis. J Comput Assist Tomogr. 29(3):346-9, 2005
- Johkoh T et al: CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests. AJR Am J Roentgenol. 158(6):1217-22, 1992
