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Lymphocytic Hypophysitis
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Lymphocytic hypophysitis (LH)
            • Synonyms

              • Adenohypophysitis, primary hypophysitis, stalkitis
            • Definitions

              • Idiopathic inflammation of pituitary gland or stalk

            IMAGING

            • General Features

              • MR Findings

                • Imaging Recommendations

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Tauziede-Espariat A et al: The prevalence of IgG4-positive plasma cells in hypophysitis: a possible relationship to IgG4-related disease. Clin Neuropathol. ePub, 2015
                                    2. Chodakiewitz Y et al: Ipilimumab treatment associated pituitary hypophysitis: clinical presentation and imaging diagnosis. Clin Neurol Neurosurg. 125:125-30, 2014
                                    3. Hunn BH et al: Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature. Pituitary. 17(4):357-65, 2014
                                    4. Imber BS et al: Hypophysitis: a single-center case series. Pituitary. ePub, 2014
                                    5. Hindocha A et al: Lymphocytic hypophysitis in males. J Clin Neurosci. 20(5):743-5, 2013
                                    6. De Bellis A et al: Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells. J Clin Endocrinol Metab. 97(10):3684-90, 2012
                                    7. Peruzzotti-Jametti L et al: Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis. J Stroke Cerebrovasc Dis. 21(8):918, 2012
                                    8. Mirocha S et al: T regulatory cells distinguish two types of primary hypophysitis. Clin Exp Immunol. 155(3):403-11, 2009
                                    9. Molitch ME et al: Lymphocytic hypophysitis. Horm Res. 68 Suppl 5:145-50, 2007
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            • Diagnostic Checklist

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Lymphocytic hypophysitis (LH)
                                              • Synonyms

                                                • Adenohypophysitis, primary hypophysitis, stalkitis
                                              • Definitions

                                                • Idiopathic inflammation of pituitary gland or stalk

                                              IMAGING

                                              • General Features

                                                • MR Findings

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Tauziede-Espariat A et al: The prevalence of IgG4-positive plasma cells in hypophysitis: a possible relationship to IgG4-related disease. Clin Neuropathol. ePub, 2015
                                                                      2. Chodakiewitz Y et al: Ipilimumab treatment associated pituitary hypophysitis: clinical presentation and imaging diagnosis. Clin Neurol Neurosurg. 125:125-30, 2014
                                                                      3. Hunn BH et al: Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature. Pituitary. 17(4):357-65, 2014
                                                                      4. Imber BS et al: Hypophysitis: a single-center case series. Pituitary. ePub, 2014
                                                                      5. Hindocha A et al: Lymphocytic hypophysitis in males. J Clin Neurosci. 20(5):743-5, 2013
                                                                      6. De Bellis A et al: Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells. J Clin Endocrinol Metab. 97(10):3684-90, 2012
                                                                      7. Peruzzotti-Jametti L et al: Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis. J Stroke Cerebrovasc Dis. 21(8):918, 2012
                                                                      8. Mirocha S et al: T regulatory cells distinguish two types of primary hypophysitis. Clin Exp Immunol. 155(3):403-11, 2009
                                                                      9. Molitch ME et al: Lymphocytic hypophysitis. Horm Res. 68 Suppl 5:145-50, 2007