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Lymphocytic Interstitial Pneumonia
Jeffrey P. Kanne, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Lymphocytic interstitial pneumonia (LIP)
            • Synonyms

              • Lymphoid interstitial pneumonia
            • Definitions

              • Diffuse polyclonal lymphocytic infiltration of alveolar septa
              • Part of spectrum of lymphoproliferative disorders
                • Follicular bronchiolitis (lymphoid hyperplasia) to lymphoma
              • Included in ATS/ERS 2001 classification of idiopathic interstitial pneumonias

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Kanne JP: Idiopathic interstitial pneumonias. Semin Roentgenol. 45(1):8-21, 2010
                                      2. Silva CI et al: Idiopathic interstitial pneumonias. J Thorac Imaging. 24(4):260-73, 2009
                                      3. Cha SI et al: Lymphoid interstitial pneumonia: clinical features, associations and prognosis. Eur Respir J. 28(2):364-9, 2006
                                      4. Silva CI et al: Diffuse lung cysts in lymphoid interstitial pneumonia: high-resolution CT and pathologic findings. J Thorac Imaging. 21(3):241-4, 2006
                                      5. Do KH et al: Pulmonary parenchymal involvement of low-grade lymphoproliferative disorders. J Comput Assist Tomogr. 29(6):825-30, 2005
                                      6. American Thoracic Society; European Respiratory Society: American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. This joint statement of the American Thoracic Society (ATS) and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 165(2):277-304, 2002
                                      7. Swigris JJ et al: Lymphoid interstitial pneumonia: a narrative review. Chest. 122(6):2150-64, 2002
                                      8. Nicholson AG: Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung. Semin Respir Crit Care Med. 22(4):409-22, 2001
                                      9. Travis WD et al: Non-neoplastic pulmonary lymphoid lesions. Thorax. 56(12):964-71, 2001
                                      10. Johkoh T et al: Lymphocytic interstitial pneumonia: follow-up CT findings in 14 patients. J Thorac Imaging. 15(3):162-7, 2000
                                      11. Honda O et al: Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT. AJR Am J Roentgenol. 173(1):71-4, 1999
                                      12. Johkoh T et al: Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology. 212(2):567-72, 1999
                                      13. Ichikawa Y et al: Lung cyst formation in lymphocytic interstitial pneumonia: CT features. J Comput Assist Tomogr. 18(5):745-8, 1994
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Lymphocytic interstitial pneumonia (LIP)
                                                • Synonyms

                                                  • Lymphoid interstitial pneumonia
                                                • Definitions

                                                  • Diffuse polyclonal lymphocytic infiltration of alveolar septa
                                                  • Part of spectrum of lymphoproliferative disorders
                                                    • Follicular bronchiolitis (lymphoid hyperplasia) to lymphoma
                                                  • Included in ATS/ERS 2001 classification of idiopathic interstitial pneumonias

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      DIAGNOSTIC CHECKLIST

                                                                      • Consider

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Kanne JP: Idiopathic interstitial pneumonias. Semin Roentgenol. 45(1):8-21, 2010
                                                                          2. Silva CI et al: Idiopathic interstitial pneumonias. J Thorac Imaging. 24(4):260-73, 2009
                                                                          3. Cha SI et al: Lymphoid interstitial pneumonia: clinical features, associations and prognosis. Eur Respir J. 28(2):364-9, 2006
                                                                          4. Silva CI et al: Diffuse lung cysts in lymphoid interstitial pneumonia: high-resolution CT and pathologic findings. J Thorac Imaging. 21(3):241-4, 2006
                                                                          5. Do KH et al: Pulmonary parenchymal involvement of low-grade lymphoproliferative disorders. J Comput Assist Tomogr. 29(6):825-30, 2005
                                                                          6. American Thoracic Society; European Respiratory Society: American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. This joint statement of the American Thoracic Society (ATS) and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 165(2):277-304, 2002
                                                                          7. Swigris JJ et al: Lymphoid interstitial pneumonia: a narrative review. Chest. 122(6):2150-64, 2002
                                                                          8. Nicholson AG: Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung. Semin Respir Crit Care Med. 22(4):409-22, 2001
                                                                          9. Travis WD et al: Non-neoplastic pulmonary lymphoid lesions. Thorax. 56(12):964-71, 2001
                                                                          10. Johkoh T et al: Lymphocytic interstitial pneumonia: follow-up CT findings in 14 patients. J Thorac Imaging. 15(3):162-7, 2000
                                                                          11. Honda O et al: Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT. AJR Am J Roentgenol. 173(1):71-4, 1999
                                                                          12. Johkoh T et al: Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology. 212(2):567-72, 1999
                                                                          13. Ichikawa Y et al: Lung cyst formation in lymphocytic interstitial pneumonia: CT features. J Comput Assist Tomogr. 18(5):745-8, 1994