Primary non-Hodgkin lymphoma of bone, primary lymphoma of bone (PLB), osteolymphoma
Definitions
Neoplasm composed of malignant lymphoid cells, producing ≥ 1 lesions within bone
PLB
≥ 1 bone lesions with no supraregional lymph node involvement or other extranodal lesions
Secondary lymphoma of bone
Lymphoma with skeletal and nonskeletal involvement
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Cleven AHG et al: Primary non-Hodgkin lymphoma of bone. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 489-91, 2020
Asenbaum U et al: Bone marrow involvement in malignant lymphoma: evaluation of quantitative PET and MRI biomarkers. Acad Radiol. 25(4):453-60, 2018
Patyk M et al: Application of the apparent diffusion coefficient in magnetic resonance imaging in an assessment of the early response to treatment in Hodgkin's and non-Hodgkin's lymphoma - pilot study. Pol J Radiol. 83:e210-4, 2018
Milks KS et al: Imaging of primary pediatric lymphoma of bone. Pediatr Radiol. 46(8):1150-7, 2016
Murphey MD et al: Primary musculoskeletal lymphoma. Radiol Clin North Am. 54(4):785-95, 2016
Messina C et al: Primary and secondary bone lymphomas. Cancer Treat Rev. 41(3):235-46, 2015
Liu YC et al: Prognostic factors and treatment efficacy in patients with primary diffuse large B-cell lymphoma of the bone: single institute experience over 11 years. Intern Med. 53(2):95-101, 2014
Wu H et al: Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 14:900, 2014
Wu H et al: Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. Br J Haematol. 166(1):60-8, 2014
Demircay E et al: Malignant lymphoma of bone: a review of 119 patients. Clin Orthop Relat Res. 471(8):2684-90, 2013
Jiang XX et al: A pooled analysis of MRI in the detection of bone marrow infiltration in patients with malignant lymphoma. Clin Radiol. 68(3):e143-53, 2013
Lim CY et al: Imaging of musculoskeletal lymphoma. Cancer Imaging. 13(4):448-57, 2013
Thomas AG et al. Extranodal lymphoma from head to toe: part 2, the trunk and extremities. AJR Am J Roentgenol. 2011 Aug;197(2):357-64, 2011
Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
Catlett JP et al: Primary lymphoma of bone: an institutional experience. Leuk Lymphoma. 49(11):2125-32, 2008
Power DG et al: Primary bone lymphoma: single institution case series. Ir J Med Sci. 177(3):247-51, 2008
Sato TS et al: Primary multifocal osseous lymphoma in a child. Pediatr Radiol. 38(12):1338-41, 2008
Ford DR et al: Primary bone lymphoma--treatment and outcome. Clin Oncol (R Coll Radiol). 19(1):50-5, 2007
Heyning FH et al: MR imaging characteristics in primary lymphoma of bone with emphasis on non-aggressive appearance. Skeletal Radiol. 36(10):937-44, 2007
Horsman JM et al: Primary bone lymphoma: a retrospective analysis. Int J Oncol. 28(6):1571-5, 2006
Mengiardi B et al: Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment. AJR Am J Roentgenol. 184(1):185-92, 2005
Krishnan A et al: Primary bone lymphoma: radiographic-MR imaging correlation. Radiographics. 23(6):1371-83; discussion 1384-7, 2003
Rahmouni A et al: Bone marrow with diffuse tumor infiltration in patients with lymphoproliferative diseases: dynamic gadolinium-enhanced MR imaging. Radiology. 229(3):710-7, 2003
Mulligan ME et al: Imaging features of primary lymphoma of bone. AJR Am J Roentgenol. 173(6):1691-7, 1999
Melamed JW et al: Imaging of primary multifocal osseous lymphoma. Skeletal Radiol. 26(1):35-41, 1997
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Diagnostic Checklist
TERMINOLOGY
Synonyms
Primary non-Hodgkin lymphoma of bone, primary lymphoma of bone (PLB), osteolymphoma
Definitions
Neoplasm composed of malignant lymphoid cells, producing ≥ 1 lesions within bone
PLB
≥ 1 bone lesions with no supraregional lymph node involvement or other extranodal lesions
Secondary lymphoma of bone
Lymphoma with skeletal and nonskeletal involvement
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Cleven AHG et al: Primary non-Hodgkin lymphoma of bone. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 489-91, 2020
Asenbaum U et al: Bone marrow involvement in malignant lymphoma: evaluation of quantitative PET and MRI biomarkers. Acad Radiol. 25(4):453-60, 2018
Patyk M et al: Application of the apparent diffusion coefficient in magnetic resonance imaging in an assessment of the early response to treatment in Hodgkin's and non-Hodgkin's lymphoma - pilot study. Pol J Radiol. 83:e210-4, 2018
Milks KS et al: Imaging of primary pediatric lymphoma of bone. Pediatr Radiol. 46(8):1150-7, 2016
Murphey MD et al: Primary musculoskeletal lymphoma. Radiol Clin North Am. 54(4):785-95, 2016
Messina C et al: Primary and secondary bone lymphomas. Cancer Treat Rev. 41(3):235-46, 2015
Liu YC et al: Prognostic factors and treatment efficacy in patients with primary diffuse large B-cell lymphoma of the bone: single institute experience over 11 years. Intern Med. 53(2):95-101, 2014
Wu H et al: Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 14:900, 2014
Wu H et al: Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. Br J Haematol. 166(1):60-8, 2014
Demircay E et al: Malignant lymphoma of bone: a review of 119 patients. Clin Orthop Relat Res. 471(8):2684-90, 2013
Jiang XX et al: A pooled analysis of MRI in the detection of bone marrow infiltration in patients with malignant lymphoma. Clin Radiol. 68(3):e143-53, 2013
Lim CY et al: Imaging of musculoskeletal lymphoma. Cancer Imaging. 13(4):448-57, 2013
Thomas AG et al. Extranodal lymphoma from head to toe: part 2, the trunk and extremities. AJR Am J Roentgenol. 2011 Aug;197(2):357-64, 2011
Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
Catlett JP et al: Primary lymphoma of bone: an institutional experience. Leuk Lymphoma. 49(11):2125-32, 2008
Power DG et al: Primary bone lymphoma: single institution case series. Ir J Med Sci. 177(3):247-51, 2008
Sato TS et al: Primary multifocal osseous lymphoma in a child. Pediatr Radiol. 38(12):1338-41, 2008
Ford DR et al: Primary bone lymphoma--treatment and outcome. Clin Oncol (R Coll Radiol). 19(1):50-5, 2007
Heyning FH et al: MR imaging characteristics in primary lymphoma of bone with emphasis on non-aggressive appearance. Skeletal Radiol. 36(10):937-44, 2007
Horsman JM et al: Primary bone lymphoma: a retrospective analysis. Int J Oncol. 28(6):1571-5, 2006
Mengiardi B et al: Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment. AJR Am J Roentgenol. 184(1):185-92, 2005
Krishnan A et al: Primary bone lymphoma: radiographic-MR imaging correlation. Radiographics. 23(6):1371-83; discussion 1384-7, 2003
Rahmouni A et al: Bone marrow with diffuse tumor infiltration in patients with lymphoproliferative diseases: dynamic gadolinium-enhanced MR imaging. Radiology. 229(3):710-7, 2003
Mulligan ME et al: Imaging features of primary lymphoma of bone. AJR Am J Roentgenol. 173(6):1691-7, 1999
Melamed JW et al: Imaging of primary multifocal osseous lymphoma. Skeletal Radiol. 26(1):35-41, 1997
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