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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Primary breast lymphoma (PBL)
Mucosa-associated lymphoid tissue (MALT)
Definitions
Clonal population of malignant lymphocytes involving breast ± axillary lymph node(s) in absence of extramammary disease
Breast parenchymal lesion required for diagnosis
Diagnosis based on Wiseman and Liao criteria
Close association of mammary tissue with lymphomatous infiltrate
No evidence of systemic lymphoma or previous extramammary lymphoma at time of diagnosis
Restricted to breast &/or ipsilateral axillary lymph nodes at time of diagnosis
Technically adequate pathologic sample
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Peñalver FJ et al: Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO). Haematologica. 102(2):235-245, 2017
Wienbeck S et al: Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study. Sci Rep. 7(1):7435, 2017
Dong A et al: Spectrum of the breast lesions with increased 18F-FDG uptake on PET/CT. Clin Nucl Med. 41(7):543-57, 2016
Nicholson BT et al: Extranodal lymphoma of the breast. Radiol Clin North Am. 54(4):711-26, 2016
Gkali CA et al: Primary non-Hodgkin lymphoma of the breast: Ultrasonography, elastography, digital mammography, contrast-enhanced digital mammography, and pathology findings. Ultrasound Q. 31(4):279-82, 2015
Wang L et al: MRI features of breast lymphoma: preliminary experience in seven cases. Diagn Interv Radiol. 21(6):441-7, 2015
Cheah CY et al: Primary breast lymphoma. Cancer Treat Rev. 40(8):900-8, 2014
Larribe M et al: Breast cancers with round lumps: correlations between imaging and anatomopathology. Diagn Interv Imaging. 95(1):37-46, 2014
Radkani P et al: Primary breast lymphoma: 30 years of experience with diagnosis and treatment at a single medical center. JAMA Surg. 149(1):91-3, 2014
Aviv A et al: Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 24(9):2236-44, 2013
Liu K et al: The features of breast lymphoma on MRI. Br J Radiol. 86(1031):20130220, 2013
Matsubayashi RN et al: MR imaging of malignant primary breast lymphoma: including diffusion-weighted imaging, histologic features, and a literature review. Jpn J Radiol. 31(10):668-76, 2013
Caon J et al: Treatment and outcomes of primary breast lymphoma. Clin Breast Cancer. 12(6):412-9, 2012
Ikeda T et al: Malignant lymphoma of the breast in a male patient: ultrasound imaging features. Breast Cancer. Epub ahead of print, 2012
Surov A et al: Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol. 85(1014):e195-205, 2012
Ginat DT et al: FDG PET/CT manifestations of hematopoietic malignancies of the breast. Acad Radiol. 17(8):1026-30, 2010
Broyde A et al: Role and prognostic significance of the Ki-67 index in non-Hodgkin's lymphoma. Am J Hematol. 84(6):338-43, 2009
Rizzo S et al: Magnetic resonance imaging of primary breast lymphoma. Radiol Med. 114(6):915-24, 2009
Kuroda H et al: Primary diffuse large B-cell lymphoma of the breast. Breast Cancer. 14(3):317-22, 2007
Lyou CY et al: Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 31(4):234-8, 2007
Woo OH et al: Synchronous bilateral primary breast lymphoma: MRI and pathologic findings. Breast J. 13(4):429-30, 2007
Yang WT et al: Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology. 245(3):692-702, 2007
Areia AL et al: Primary breast lymphoma. Eur J Gynaecol Oncol. 26(2):163-4, 2005
Baker R et al: Multifocal primary breast lymphoma. South Med J. 98(10):1045-8, 2005
Espinosa LA et al: MRI features of mucosa-associated lymphoid tissue lymphoma in the breast. AJR Am J Roentgenol. 185(1):199-202, 2005
Fruchart C et al: High grade primary breast lymphoma: is it a different clinical entity? Breast Cancer Res Treat. 93(3):191-8, 2005
Grubstein A et al: Extranodal primary B-cell non-Hodgkin lymphoma of the breast mimicking acute mastitis. J Clin Ultrasound. 33(3):140-2, 2005
Kebudi A et al: Primary T-lymphoma of the breast with bilateral involvement, unusual presentation. Int J Clin Pract Suppl. (147):95-8, 2005
Kumar R et al: F-18 FDG positron emission tomography in non-Hodgkin lymphoma of the breast. Clin Nucl Med. 30(4):246-8, 2005
Liu MT et al: Primary breast lymphoma: a pooled analysis of prognostic factors and survival in 93 cases. Ann Saudi Med. 25(4):288-93, 2005
Maounis N et al: Bilateral primary lymphoma of the breast: a case report initially diagnosed by FNAC. Diagn Cytopathol. 32(2):114-8, 2005
Mason HS et al: Primary breast lymphoma: radiologic and pathologic findings. Breast J. 11(6):495-6, 2005
Vardar E et al: Primary breast lymphoma cytologic diagnosis. Arch Pathol Lab Med. 129(5):694-6, 2005
Venizelos ID et al: Primary non-Hodgkin's lymphoma arising in an intramammary lymph node. Leuk Lymphoma. 46(3):451-5, 2005
Vignot S et al: Non-Hodgkin's lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma. 6(1):37-42, 2005
Carrascosa LA et al: Synchronous primary bilateral breast lymphoma. Am J Clin Oncol. 27(6):635, 2004
Loughrey MB et al: WHO reclassification of breast lymphomas. J Clin Pathol. 57(11):1213-4, 2004
Mpallas G et al: Primary breast lymphoma in a male patient. Breast. 13(5):436-8, 2004
Pruthi S et al: Primary mammary (non-Hodgkin) lymphoma presenting as locally advanced breast cancer. Mayo Clin Proc. 79(10):1310-4, 2004
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Primary breast lymphoma (PBL)
Mucosa-associated lymphoid tissue (MALT)
Definitions
Clonal population of malignant lymphocytes involving breast ± axillary lymph node(s) in absence of extramammary disease
Breast parenchymal lesion required for diagnosis
Diagnosis based on Wiseman and Liao criteria
Close association of mammary tissue with lymphomatous infiltrate
No evidence of systemic lymphoma or previous extramammary lymphoma at time of diagnosis
Restricted to breast &/or ipsilateral axillary lymph nodes at time of diagnosis
Technically adequate pathologic sample
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Peñalver FJ et al: Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO). Haematologica. 102(2):235-245, 2017
Wienbeck S et al: Radiological imaging characteristics of intramammary hematological malignancies: results from a german multicenter study. Sci Rep. 7(1):7435, 2017
Dong A et al: Spectrum of the breast lesions with increased 18F-FDG uptake on PET/CT. Clin Nucl Med. 41(7):543-57, 2016
Nicholson BT et al: Extranodal lymphoma of the breast. Radiol Clin North Am. 54(4):711-26, 2016
Gkali CA et al: Primary non-Hodgkin lymphoma of the breast: Ultrasonography, elastography, digital mammography, contrast-enhanced digital mammography, and pathology findings. Ultrasound Q. 31(4):279-82, 2015
Wang L et al: MRI features of breast lymphoma: preliminary experience in seven cases. Diagn Interv Radiol. 21(6):441-7, 2015
Cheah CY et al: Primary breast lymphoma. Cancer Treat Rev. 40(8):900-8, 2014
Larribe M et al: Breast cancers with round lumps: correlations between imaging and anatomopathology. Diagn Interv Imaging. 95(1):37-46, 2014
Radkani P et al: Primary breast lymphoma: 30 years of experience with diagnosis and treatment at a single medical center. JAMA Surg. 149(1):91-3, 2014
Aviv A et al: Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 24(9):2236-44, 2013
Liu K et al: The features of breast lymphoma on MRI. Br J Radiol. 86(1031):20130220, 2013
Matsubayashi RN et al: MR imaging of malignant primary breast lymphoma: including diffusion-weighted imaging, histologic features, and a literature review. Jpn J Radiol. 31(10):668-76, 2013
Caon J et al: Treatment and outcomes of primary breast lymphoma. Clin Breast Cancer. 12(6):412-9, 2012
Ikeda T et al: Malignant lymphoma of the breast in a male patient: ultrasound imaging features. Breast Cancer. Epub ahead of print, 2012
Surov A et al: Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol. 85(1014):e195-205, 2012
Ginat DT et al: FDG PET/CT manifestations of hematopoietic malignancies of the breast. Acad Radiol. 17(8):1026-30, 2010
Broyde A et al: Role and prognostic significance of the Ki-67 index in non-Hodgkin's lymphoma. Am J Hematol. 84(6):338-43, 2009
Rizzo S et al: Magnetic resonance imaging of primary breast lymphoma. Radiol Med. 114(6):915-24, 2009
Kuroda H et al: Primary diffuse large B-cell lymphoma of the breast. Breast Cancer. 14(3):317-22, 2007
Lyou CY et al: Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 31(4):234-8, 2007
Woo OH et al: Synchronous bilateral primary breast lymphoma: MRI and pathologic findings. Breast J. 13(4):429-30, 2007
Yang WT et al: Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology. 245(3):692-702, 2007
Areia AL et al: Primary breast lymphoma. Eur J Gynaecol Oncol. 26(2):163-4, 2005
Baker R et al: Multifocal primary breast lymphoma. South Med J. 98(10):1045-8, 2005
Espinosa LA et al: MRI features of mucosa-associated lymphoid tissue lymphoma in the breast. AJR Am J Roentgenol. 185(1):199-202, 2005
Fruchart C et al: High grade primary breast lymphoma: is it a different clinical entity? Breast Cancer Res Treat. 93(3):191-8, 2005
Grubstein A et al: Extranodal primary B-cell non-Hodgkin lymphoma of the breast mimicking acute mastitis. J Clin Ultrasound. 33(3):140-2, 2005
Kebudi A et al: Primary T-lymphoma of the breast with bilateral involvement, unusual presentation. Int J Clin Pract Suppl. (147):95-8, 2005
Kumar R et al: F-18 FDG positron emission tomography in non-Hodgkin lymphoma of the breast. Clin Nucl Med. 30(4):246-8, 2005
Liu MT et al: Primary breast lymphoma: a pooled analysis of prognostic factors and survival in 93 cases. Ann Saudi Med. 25(4):288-93, 2005
Maounis N et al: Bilateral primary lymphoma of the breast: a case report initially diagnosed by FNAC. Diagn Cytopathol. 32(2):114-8, 2005
Mason HS et al: Primary breast lymphoma: radiologic and pathologic findings. Breast J. 11(6):495-6, 2005
Vardar E et al: Primary breast lymphoma cytologic diagnosis. Arch Pathol Lab Med. 129(5):694-6, 2005
Venizelos ID et al: Primary non-Hodgkin's lymphoma arising in an intramammary lymph node. Leuk Lymphoma. 46(3):451-5, 2005
Vignot S et al: Non-Hodgkin's lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma. 6(1):37-42, 2005
Carrascosa LA et al: Synchronous primary bilateral breast lymphoma. Am J Clin Oncol. 27(6):635, 2004
Loughrey MB et al: WHO reclassification of breast lymphomas. J Clin Pathol. 57(11):1213-4, 2004
Mpallas G et al: Primary breast lymphoma in a male patient. Breast. 13(5):436-8, 2004
Pruthi S et al: Primary mammary (non-Hodgkin) lymphoma presenting as locally advanced breast cancer. Mayo Clin Proc. 79(10):1310-4, 2004
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