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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Non-Hodgkin lymphoma (NHL)
Definitions
Clonal population of malignant lymphocytes involving breast
2 distinct entities
Primary breast lymphoma
Restricted to breast parenchyma ± axillary nodes at diagnosis without previous known lymphoma
Secondary (metastatic) lymphoma involving breast
Breast ± axillary node involvement in patient with concurrent or prior systemic lymphoma
Rare, < 0.5% of breast malignancies; ~ 5% of extranodal lymphomas; more common than primary breast lymphoma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
CT Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Ollila TA et al: Extranodal diffuse large B-cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol. 19(8):38, 2018
Alsadi A et al: Hematologic malignancies discovered on investigation of breast abnormalities. South Med J. 110(10):614-20, 2017
Hoffmann J et al: Hematolymphoid lesions of the breast. Semin Diagn Pathol. 34(5):462-9, 2017
Marinopoulos S et al: Breast lymphoma in a patient with B-cell non-Hodgkin lymphoma: a case report study. Int J Surg Case Rep. 40:1-5, 2017
Wienbeck S et al: Radiological imaging characteristics of intramammary hematological malignancies: results from a German multicenter study. Sci Rep. 7(1):7435, 2017
Nicholson BT et al: Extranodal lymphoma of the breast. Radiol Clin North Am. 54(4):711-26, 2016
Sousaris N et al: Sonoelastography of breast lymphoma. Ultrasound Q. 32(3):208-11, 2016
Ikeda T et al: Malignant lymphoma of the breast in a male patient: ultrasound imaging features. Breast Cancer. 22(2):201-5, 2015
Glazebrook KN et al: Breast imaging findings in haematological malignancies. Insights Imaging. 5(6):715-22, 2014
Surov A et al: Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol. 85(1014):e195-205, 2012
Ilica AT et al: Imaging of extranodal lymphoma with PET/CT. Clin Nucl Med. 36(10):e127-38, 2011
Thomas AG et al: Extranodal lymphoma from head to toe: part 2, the trunk and extremities. AJR Am J Roentgenol. 197(2):357-64, 2011
Ginat DT et al: FDG PET/CT manifestations of hematopoietic malignancies of the breast. Acad Radiol. 17(8):1026-30, 2010
Ng A et al: ACR Appropriateness Criteria: follow-up of Hodgkin's lymphoma. Curr Probl Cancer. 34(3):211-27, 2010
Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
Rizzo S et al: Magnetic resonance imaging of primary breast lymphoma. Radiol Med. 114(6):915-24, 2009
Talwalkar SS et al: Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol. 32(9):1299-309, 2008
Kuroda H et al: Primary diffuse large B-cell lymphoma of the breast. Breast Cancer. 14(3):317-22, 2007
Lyou CY et al: Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 31(4):234-8, 2007
Woo OH et al: Synchronous bilateral primary breast lymphoma: MRI and pathologic findings. Breast J. 13(4):429-30, 2007
Yang WT et al: Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology. 245(3):692-702, 2007
Grubstein A et al: Extranodal primary B-cell non-Hodgkin lymphoma of the breast mimicking acute mastitis. J Clin Ultrasound. 33(3):140-2, 2005
Kumar R et al: F-18 FDG positron emission tomography in non-Hodgkin lymphoma of the breast. Clin Nucl Med. 30(4):246-8, 2005
Vignot S et al: Non-Hodgkin's lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma. 6(1):37-42, 2005
Loughrey MB et al: WHO reclassification of breast lymphomas. J Clin Pathol. 57(11):1213-4, 2004
Mattia AR et al: Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol. 17(6):574-87, 1993
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Non-Hodgkin lymphoma (NHL)
Definitions
Clonal population of malignant lymphocytes involving breast
2 distinct entities
Primary breast lymphoma
Restricted to breast parenchyma ± axillary nodes at diagnosis without previous known lymphoma
Secondary (metastatic) lymphoma involving breast
Breast ± axillary node involvement in patient with concurrent or prior systemic lymphoma
Rare, < 0.5% of breast malignancies; ~ 5% of extranodal lymphomas; more common than primary breast lymphoma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
CT Findings
Image-Guided Biopsy
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Ollila TA et al: Extranodal diffuse large B-cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol. 19(8):38, 2018
Alsadi A et al: Hematologic malignancies discovered on investigation of breast abnormalities. South Med J. 110(10):614-20, 2017
Hoffmann J et al: Hematolymphoid lesions of the breast. Semin Diagn Pathol. 34(5):462-9, 2017
Marinopoulos S et al: Breast lymphoma in a patient with B-cell non-Hodgkin lymphoma: a case report study. Int J Surg Case Rep. 40:1-5, 2017
Wienbeck S et al: Radiological imaging characteristics of intramammary hematological malignancies: results from a German multicenter study. Sci Rep. 7(1):7435, 2017
Nicholson BT et al: Extranodal lymphoma of the breast. Radiol Clin North Am. 54(4):711-26, 2016
Sousaris N et al: Sonoelastography of breast lymphoma. Ultrasound Q. 32(3):208-11, 2016
Ikeda T et al: Malignant lymphoma of the breast in a male patient: ultrasound imaging features. Breast Cancer. 22(2):201-5, 2015
Glazebrook KN et al: Breast imaging findings in haematological malignancies. Insights Imaging. 5(6):715-22, 2014
Surov A et al: Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol. 85(1014):e195-205, 2012
Ilica AT et al: Imaging of extranodal lymphoma with PET/CT. Clin Nucl Med. 36(10):e127-38, 2011
Thomas AG et al: Extranodal lymphoma from head to toe: part 2, the trunk and extremities. AJR Am J Roentgenol. 197(2):357-64, 2011
Ginat DT et al: FDG PET/CT manifestations of hematopoietic malignancies of the breast. Acad Radiol. 17(8):1026-30, 2010
Ng A et al: ACR Appropriateness Criteria: follow-up of Hodgkin's lymphoma. Curr Probl Cancer. 34(3):211-27, 2010
Chua SC et al: Imaging features of primary extranodal lymphomas. Clin Radiol. 64(6):574-88, 2009
Rizzo S et al: Magnetic resonance imaging of primary breast lymphoma. Radiol Med. 114(6):915-24, 2009
Talwalkar SS et al: Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol. 32(9):1299-309, 2008
Kuroda H et al: Primary diffuse large B-cell lymphoma of the breast. Breast Cancer. 14(3):317-22, 2007
Lyou CY et al: Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging. 31(4):234-8, 2007
Woo OH et al: Synchronous bilateral primary breast lymphoma: MRI and pathologic findings. Breast J. 13(4):429-30, 2007
Yang WT et al: Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology. 245(3):692-702, 2007
Grubstein A et al: Extranodal primary B-cell non-Hodgkin lymphoma of the breast mimicking acute mastitis. J Clin Ultrasound. 33(3):140-2, 2005
Kumar R et al: F-18 FDG positron emission tomography in non-Hodgkin lymphoma of the breast. Clin Nucl Med. 30(4):246-8, 2005
Vignot S et al: Non-Hodgkin's lymphoma of the breast: a report of 19 cases and a review of the literature. Clin Lymphoma. 6(1):37-42, 2005
Loughrey MB et al: WHO reclassification of breast lymphomas. J Clin Pathol. 57(11):1213-4, 2004
Mattia AR et al: Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol. 17(6):574-87, 1993
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