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Lymphoma
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL)
          • Synonyms

            • Hodgkin disease
          • Definitions

            • Lymphoma: Malignant neoplasm arising from constituent cells of immune system or their precursors
              • Classic HL subtypes: Nodular sclerosis (NS), lymphocyte rich (LR), mixed cellularity (MC), lymphocyte depleted (LD)
              • NHL subtypes: Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), anaplastic large cell lymphoma (ALCL), lymphoblastic lymphoma (LBL)

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Allen CE et al: Pediatric lymphomas and histiocytic disorders of childhood. Pediatr Clin North Am. 62(1):139-65, 2015
                                          2. Minard-Colin V et al: Non-Hodgkin lymphoma in children and adolescents: progress through effective collaboration, current knowledge, and challenges ahead. J Clin Oncol. 33(27):2963-74, 2015
                                          3. Atkin KL et al: The role of whole-body MRI in pediatric oncology. J Pediatr Hematol Oncol. 36(5):342-52, 2014
                                          4. Dokmanović L et al: Non-Hodgkin lymphomas in childhood: how to move on? Srp Arh Celok Lek. 142(7-8):498-504, 2014
                                          5. Terezakis SA et al: ACR appropriateness criteria pediatric Hodgkin lymphoma. Pediatr Blood Cancer. 61(7):1305-12, 2014
                                          6. Averill LW et al: Update on pediatric leukemia and lymphoma imaging. Semin Ultrasound CT MR. 34(6):578-99, 2013
                                          7. Qiu L et al: The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hell J Nucl Med. 16(3):230-6, 2013
                                          8. Toma P et al: Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 27(5):1335-54, 2007
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL)
                                                  • Synonyms

                                                    • Hodgkin disease
                                                  • Definitions

                                                    • Lymphoma: Malignant neoplasm arising from constituent cells of immune system or their precursors
                                                      • Classic HL subtypes: Nodular sclerosis (NS), lymphocyte rich (LR), mixed cellularity (MC), lymphocyte depleted (LD)
                                                      • NHL subtypes: Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), anaplastic large cell lymphoma (ALCL), lymphoblastic lymphoma (LBL)

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Allen CE et al: Pediatric lymphomas and histiocytic disorders of childhood. Pediatr Clin North Am. 62(1):139-65, 2015
                                                                                  2. Minard-Colin V et al: Non-Hodgkin lymphoma in children and adolescents: progress through effective collaboration, current knowledge, and challenges ahead. J Clin Oncol. 33(27):2963-74, 2015
                                                                                  3. Atkin KL et al: The role of whole-body MRI in pediatric oncology. J Pediatr Hematol Oncol. 36(5):342-52, 2014
                                                                                  4. Dokmanović L et al: Non-Hodgkin lymphomas in childhood: how to move on? Srp Arh Celok Lek. 142(7-8):498-504, 2014
                                                                                  5. Terezakis SA et al: ACR appropriateness criteria pediatric Hodgkin lymphoma. Pediatr Blood Cancer. 61(7):1305-12, 2014
                                                                                  6. Averill LW et al: Update on pediatric leukemia and lymphoma imaging. Semin Ultrasound CT MR. 34(6):578-99, 2013
                                                                                  7. Qiu L et al: The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hell J Nucl Med. 16(3):230-6, 2013
                                                                                  8. Toma P et al: Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 27(5):1335-54, 2007