Spread of primary tumor to spine, where bone destruction exceeds bone production
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Barzilai O et al: State of the art treatment of spinal metastatic disease. Neurosurgery. 82(6):757-69, 2018
Matamalas A et al: Team approach: metastatic disease of the spine. JBJS Rev. 6(5):e6, 2018
Kumar N et al: Evolution in treatment strategy for metastatic spine disease: presently evolving modalities. Eur J Surg Oncol. 43(9):1784-801, 2017
Kaloostian PE et al: Current paradigms for metastatic spinal disease: an evidence-based review. Ann Surg Oncol. 21(1):248-62, 2014
Molina CA et al: Diagnosis and management of metastatic cervical spine tumors. Orthop Clin North Am. 43(1):75-87, viii-ix, 2012
Quraishi NA et al: Management of metastatic sacral tumours. Eur Spine J. 21(10):1984-93, 2012
Heran MK: Preoperative embolization of spinal metastatic disease: rationale and technical considerations. Semin Musculoskelet Radiol. 15(2):135-42, 2011
Munk PL et al: Fire and ice: percutaneous ablative therapies and cement injection in management of metastatic disease of the spine. Semin Musculoskelet Radiol. 15(2):125-34, 2011
Fehlings MG et al: Decision making in the surgical treatment of cervical spine metastases. Spine (Phila Pa 1976). 34(22 Suppl):S108-17, 2009
Guillevin R et al: Spine metastasis imaging: review of the literature. J Neuroradiol. 34(5):311-21, 2007
Kubota T et al: High-resolution imaging of the spine using multidetector-row computed tomography: differentiation between benign and malignant vertebral compression fractures. J Comput Assist Tomogr. 29(5):712-9, 2005
Tokuhashi Y et al: A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 30(19):2186-91, 2005
Aebi M: Spinal metastasis in the elderly. Eur Spine J. 12 Suppl 2:S202-13, 2003
Chang EL et al: Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 8(5):398-410, 2003
Lipton A: Bone metastases in breast cancer. Curr Treat Options Oncol. 4(2):151-8, 2003
Tomita K et al: Surgical strategy for spinal metastases. Spine. 26(3):298-306, 2001
Castillo M et al: Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol. 21(5):948-53, 2000
Murphy KJ et al: Percutaneous vertebroplasty in benign and malignant disease. Neuroimaging Clin N Am. 10(3):535-45, 2000
Wetzel FT et al: Management of metastatic disease of the spine. Orthop Clin North Am. 31(4):611-21, 2000
Chamberlain MC et al: Epidural spinal cord compression: a single institution's retrospective experience. Neuro Oncol. 1(2):120-3, 1999
Cook AM et al: Magnetic resonance imaging of the whole spine in suspected malignant spinal cord compression: impact on management. Clin Oncol (R Coll Radiol). 10(1):39-43, 1998
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Osteolytic metastases
Definitions
Spread of primary tumor to spine, where bone destruction exceeds bone production
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nonvascular Interventions
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Image Interpretation Pearls
Selected References
Barzilai O et al: State of the art treatment of spinal metastatic disease. Neurosurgery. 82(6):757-69, 2018
Matamalas A et al: Team approach: metastatic disease of the spine. JBJS Rev. 6(5):e6, 2018
Kumar N et al: Evolution in treatment strategy for metastatic spine disease: presently evolving modalities. Eur J Surg Oncol. 43(9):1784-801, 2017
Kaloostian PE et al: Current paradigms for metastatic spinal disease: an evidence-based review. Ann Surg Oncol. 21(1):248-62, 2014
Molina CA et al: Diagnosis and management of metastatic cervical spine tumors. Orthop Clin North Am. 43(1):75-87, viii-ix, 2012
Quraishi NA et al: Management of metastatic sacral tumours. Eur Spine J. 21(10):1984-93, 2012
Heran MK: Preoperative embolization of spinal metastatic disease: rationale and technical considerations. Semin Musculoskelet Radiol. 15(2):135-42, 2011
Munk PL et al: Fire and ice: percutaneous ablative therapies and cement injection in management of metastatic disease of the spine. Semin Musculoskelet Radiol. 15(2):125-34, 2011
Fehlings MG et al: Decision making in the surgical treatment of cervical spine metastases. Spine (Phila Pa 1976). 34(22 Suppl):S108-17, 2009
Guillevin R et al: Spine metastasis imaging: review of the literature. J Neuroradiol. 34(5):311-21, 2007
Kubota T et al: High-resolution imaging of the spine using multidetector-row computed tomography: differentiation between benign and malignant vertebral compression fractures. J Comput Assist Tomogr. 29(5):712-9, 2005
Tokuhashi Y et al: A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 30(19):2186-91, 2005
Aebi M: Spinal metastasis in the elderly. Eur Spine J. 12 Suppl 2:S202-13, 2003
Chang EL et al: Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 8(5):398-410, 2003
Lipton A: Bone metastases in breast cancer. Curr Treat Options Oncol. 4(2):151-8, 2003
Tomita K et al: Surgical strategy for spinal metastases. Spine. 26(3):298-306, 2001
Castillo M et al: Diffusion-weighted MR imaging offers no advantage over routine noncontrast MR imaging in the detection of vertebral metastases. AJNR Am J Neuroradiol. 21(5):948-53, 2000
Murphy KJ et al: Percutaneous vertebroplasty in benign and malignant disease. Neuroimaging Clin N Am. 10(3):535-45, 2000
Wetzel FT et al: Management of metastatic disease of the spine. Orthop Clin North Am. 31(4):611-21, 2000
Chamberlain MC et al: Epidural spinal cord compression: a single institution's retrospective experience. Neuro Oncol. 1(2):120-3, 1999
Cook AM et al: Magnetic resonance imaging of the whole spine in suspected malignant spinal cord compression: impact on management. Clin Oncol (R Coll Radiol). 10(1):39-43, 1998
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