Dublin JC et al: Nodal metastases in pediatric and adult acinic cell carcinoma of the major salivary glands. Otolaryngol Head Neck Surg. ePub, 2022
Ladbury C et al: Prognostic impact of primary tumor extent and postoperative radiation facility location in major salivary gland malignancies. Cureus. 14(4):e24038, 2022
Pharaon RR et al: Prolonged response to checkpoint inhibitor therapy in two metastatic mucoepidermoid salivary gland carcinoma cases: a research report. Cold Spring Harb Mol Case Stud. 8(3), 2022
Tranchito E et al: Occult nodal metastasis in major salivary gland malignancy: an update from the National Cancer Database. Oral Oncol. ePub, 2022
Yan F et al: Elective neck dissection in salivary gland malignancies: systematic review and meta-analysis. Head Neck. 44(2):505-17, 2022
Ma G et al: Intravoxel incoherent motion magnetic resonance imaging for assessing parotid gland tumors: correlation and comparison with arterial spin labeling imaging. Korean J Radiol. 22(2):243-52, 2021
Wei PY et al: Diagnostic value of maximum signal intensity on T1-weighted MRI images for differentiating parotid gland tumours along with pathological correlation. Clin Radiol. 76(6):472.e19-25, 2021
Wei P et al: Quantitative analysis and pathological basis of signal intensity on t2-weighted MR images in benign and malignant parotid tumors. Cancer Manag Res. 13:5423-31, 2021
Fang Q et al: Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients. Cancer Manag Res. 11:1081-5, 2019
Lei BW et al: Lymph node ratio (LNR) as a complementary staging system to TNM staging in salivary gland cancer. Eur Arch Otorhinolaryngol. 276(12):3425-34, 2019
Niu X et al: Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland. BMC Cancer. 19(1):417, 2019
Aro K et al: Development of a novel salivary gland cancer lymph node staging system. Cancer. 124(15):3171-80, 2018
Aro K et al: Submandibular gland cancer: Specific features and treatment considerations. Head Neck. 40(1):154-62, 2018
Forner D et al: Secretory carcinoma: the eastern Canadian experience and literature review. J Otolaryngol Head Neck Surg. 47(1):69, 2018
Jang JY et al: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer. 18(1):672, 2018
Szewczyk M et al: Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 23(4):260-5, 2018
Atula T et al: Preoperative evaluation and surgical planning of submandibular gland tumors. Head Neck. 39(6):1071-7, 2017
Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
Gilbert MR et al: A 20-year review of 75 cases of salivary duct carcinoma. JAMA Otolaryngol Head Neck Surg. 142(5):489-95, 2016
Shinomiya H et al: Patterns of lymph node metastasis of parotid cancer. Auris Nasus Larynx. 43(4):446-50, 2016
Liu S et al: Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma. J Craniomaxillofac Surg. 42(8):1891-6, 2014
Ali S et al: Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. Ann Surg Oncol. 20(7):2396-404, 2013
Friedman ER et al: Pitfalls in the staging of cancer of the major salivary gland neoplasms. Neuroimaging Clin N Am. 23(1):107-22, 2013
Feinstein TM et al: Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy. Head Neck. 33(3):318-23, 2011
Guzzo M et al: Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 74(2):134-48, 2010
van der Schroeff MP et al: Cytology and histology have limited added value in prognostic models for salivary gland carcinomas. Oral Oncol. 46(9):662-6, 2010
Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
Nagliati M et al: Surgery and radiotherapy in the treatment of malignant parotid tumors: a retrospective multicenter study. Tumori. 95(4):442-8, 2009
Takahama Junior A et al: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol. 75(4):497-501, 2009
Moreno M et al: Sentinel lymph node biopsy in adenocarcinoma of minor salivary gland. Oral Oncol. 44(3):305-8, 2008
Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
Cermik TF et al: FDG PET in detecting primary and recurrent malignant salivary gland tumors. Clin Nucl Med. 32(4):286-91, 2007
de Ru JA et al: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg. 65(5):945-52, 2007
Roh JL et al: Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med. 48(2):240-6, 2007
Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
Tincani AJ et al: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J. 124(1):26-30, 2006
Bell RB et al: Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg. 63(7):917-28, 2005
Fiorella R et al: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital. 2005 Jun;25(3):182-90. Erratum in: Acta Otorhinolaryngol Ital. 25(5):following 337, 2005
Witt RL: Major salivary gland cancer. Surg Oncol Clin N Am. 13(1):113-27, 2004
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
OVERVIEW
General Comments
Classification
PATHOLOGY
Routes of Spread
General Features
Gross Pathology & Surgical Features
Microscopic Features
IMAGING FINDINGS
Detection
Staging
Restaging
CLINICAL ISSUES
Presentation
Cancer Natural History & Prognosis
Treatment Options
REPORTING CHECKLIST
T Staging
N Staging
M Staging
Selected References
Alvi S et al: Parotid Cancer. StatPearls. 2022
Dublin JC et al: Nodal metastases in pediatric and adult acinic cell carcinoma of the major salivary glands. Otolaryngol Head Neck Surg. ePub, 2022
Ladbury C et al: Prognostic impact of primary tumor extent and postoperative radiation facility location in major salivary gland malignancies. Cureus. 14(4):e24038, 2022
Pharaon RR et al: Prolonged response to checkpoint inhibitor therapy in two metastatic mucoepidermoid salivary gland carcinoma cases: a research report. Cold Spring Harb Mol Case Stud. 8(3), 2022
Tranchito E et al: Occult nodal metastasis in major salivary gland malignancy: an update from the National Cancer Database. Oral Oncol. ePub, 2022
Yan F et al: Elective neck dissection in salivary gland malignancies: systematic review and meta-analysis. Head Neck. 44(2):505-17, 2022
Ma G et al: Intravoxel incoherent motion magnetic resonance imaging for assessing parotid gland tumors: correlation and comparison with arterial spin labeling imaging. Korean J Radiol. 22(2):243-52, 2021
Wei PY et al: Diagnostic value of maximum signal intensity on T1-weighted MRI images for differentiating parotid gland tumours along with pathological correlation. Clin Radiol. 76(6):472.e19-25, 2021
Wei P et al: Quantitative analysis and pathological basis of signal intensity on t2-weighted MR images in benign and malignant parotid tumors. Cancer Manag Res. 13:5423-31, 2021
Fang Q et al: Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients. Cancer Manag Res. 11:1081-5, 2019
Lei BW et al: Lymph node ratio (LNR) as a complementary staging system to TNM staging in salivary gland cancer. Eur Arch Otorhinolaryngol. 276(12):3425-34, 2019
Niu X et al: Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland. BMC Cancer. 19(1):417, 2019
Aro K et al: Development of a novel salivary gland cancer lymph node staging system. Cancer. 124(15):3171-80, 2018
Aro K et al: Submandibular gland cancer: Specific features and treatment considerations. Head Neck. 40(1):154-62, 2018
Forner D et al: Secretory carcinoma: the eastern Canadian experience and literature review. J Otolaryngol Head Neck Surg. 47(1):69, 2018
Jang JY et al: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer. 18(1):672, 2018
Szewczyk M et al: Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 23(4):260-5, 2018
Atula T et al: Preoperative evaluation and surgical planning of submandibular gland tumors. Head Neck. 39(6):1071-7, 2017
Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
Gilbert MR et al: A 20-year review of 75 cases of salivary duct carcinoma. JAMA Otolaryngol Head Neck Surg. 142(5):489-95, 2016
Shinomiya H et al: Patterns of lymph node metastasis of parotid cancer. Auris Nasus Larynx. 43(4):446-50, 2016
Liu S et al: Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma. J Craniomaxillofac Surg. 42(8):1891-6, 2014
Ali S et al: Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. Ann Surg Oncol. 20(7):2396-404, 2013
Friedman ER et al: Pitfalls in the staging of cancer of the major salivary gland neoplasms. Neuroimaging Clin N Am. 23(1):107-22, 2013
Feinstein TM et al: Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy. Head Neck. 33(3):318-23, 2011
Guzzo M et al: Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 74(2):134-48, 2010
van der Schroeff MP et al: Cytology and histology have limited added value in prognostic models for salivary gland carcinomas. Oral Oncol. 46(9):662-6, 2010
Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
Nagliati M et al: Surgery and radiotherapy in the treatment of malignant parotid tumors: a retrospective multicenter study. Tumori. 95(4):442-8, 2009
Takahama Junior A et al: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol. 75(4):497-501, 2009
Moreno M et al: Sentinel lymph node biopsy in adenocarcinoma of minor salivary gland. Oral Oncol. 44(3):305-8, 2008
Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
Cermik TF et al: FDG PET in detecting primary and recurrent malignant salivary gland tumors. Clin Nucl Med. 32(4):286-91, 2007
de Ru JA et al: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg. 65(5):945-52, 2007
Roh JL et al: Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med. 48(2):240-6, 2007
Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
Tincani AJ et al: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J. 124(1):26-30, 2006
Bell RB et al: Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg. 63(7):917-28, 2005
Fiorella R et al: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital. 2005 Jun;25(3):182-90. Erratum in: Acta Otorhinolaryngol Ital. 25(5):following 337, 2005
Witt RL: Major salivary gland cancer. Surg Oncol Clin N Am. 13(1):113-27, 2004
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