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Major Salivary Gland Carcinoma
Philip R. Chapman, MD
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7

OVERVIEW

  • General Comments

    • Classification

      PATHOLOGY

      • Routes of Spread

        • General Features

          • Gross Pathology & Surgical Features

            • Microscopic Features

              IMAGING FINDINGS

              • Detection

                • Staging

                  • Restaging

                    CLINICAL ISSUES

                    • Presentation

                      • Cancer Natural History & Prognosis

                        • Treatment Options

                          REPORTING CHECKLIST

                          • T Staging

                            • N Staging

                              • M Staging

                                Selected References

                                1. Fang Q et al: Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients. Cancer Manag Res. 11:1081-5, 2019
                                2. Niu X et al: Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland. BMC Cancer. 19(1):417, 2019
                                3. Aro K et al: Development of a novel salivary gland cancer lymph node staging system. Cancer. 124(15):3171-80, 2018
                                4. Aro K et al: Submandibular gland cancer: Specific features and treatment considerations. Head Neck. 40(1):154-62, 2018
                                5. Forner D et al: Secretory carcinoma: the eastern Canadian experience and literature review. J Otolaryngol Head Neck Surg. 47(1):69, 2018
                                6. Jang JY et al: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer. 18(1):672, 2018
                                7. Szewczyk M et al: Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 23(4):260-5, 2018
                                8. Atula T et al: Preoperative evaluation and surgical planning of submandibular gland tumors. Head Neck. 39(6):1071-7, 2017
                                9. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                10. Gilbert MR et al: A 20-year review of 75 cases of salivary duct carcinoma. JAMA Otolaryngol Head Neck Surg. 142(5):489-95, 2016
                                11. Liu S et al: Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma. J Craniomaxillofac Surg. 42(8):1891-6, 2014
                                12. Ali S et al: Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. Ann Surg Oncol. 20(7):2396-404, 2013
                                13. Friedman ER et al: Pitfalls in the staging of cancer of the major salivary gland neoplasms. Neuroimaging Clin N Am. 23(1):107-22, 2013
                                14. Feinstein TM et al: Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy. Head Neck. 33(3):318-23, 2011
                                15. Guzzo M et al: Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 74(2):134-48, 2010
                                16. van der Schroeff MP et al: Cytology and histology have limited added value in prognostic models for salivary gland carcinomas. Oral Oncol. 46(9):662-6, 2010
                                17. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                18. Nagliati M et al: Surgery and radiotherapy in the treatment of malignant parotid tumors: a retrospective multicenter study. Tumori. 95(4):442-8, 2009
                                19. Takahama Junior A et al: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol. 75(4):497-501, 2009
                                20. Moreno M et al: Sentinel lymph node biopsy in adenocarcinoma of minor salivary gland. Oral Oncol. 44(3):305-8, 2008
                                21. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                22. Cermik TF et al: FDG PET in detecting primary and recurrent malignant salivary gland tumors. Clin Nucl Med. 32(4):286-91, 2007
                                23. de Ru JA et al: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg. 65(5):945-52, 2007
                                24. Roh JL et al: Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med. 48(2):240-6, 2007
                                25. Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
                                26. Tincani AJ et al: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J. 124(1):26-30, 2006
                                27. Bell RB et al: Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg. 63(7):917-28, 2005
                                28. Fiorella R et al: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital. 2005 Jun;25(3):182-90. Erratum in: Acta Otorhinolaryngol Ital. 25(5):following 337, 2005
                                29. Witt RL: Major salivary gland cancer. Surg Oncol Clin N Am. 13(1):113-27, 2004
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                OVERVIEW

                                • General Comments

                                  • Classification

                                    PATHOLOGY

                                    • Routes of Spread

                                      • General Features

                                        • Gross Pathology & Surgical Features

                                          • Microscopic Features

                                            IMAGING FINDINGS

                                            • Detection

                                              • Staging

                                                • Restaging

                                                  CLINICAL ISSUES

                                                  • Presentation

                                                    • Cancer Natural History & Prognosis

                                                      • Treatment Options

                                                        REPORTING CHECKLIST

                                                        • T Staging

                                                          • N Staging

                                                            • M Staging

                                                              Selected References

                                                              1. Fang Q et al: Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients. Cancer Manag Res. 11:1081-5, 2019
                                                              2. Niu X et al: Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland. BMC Cancer. 19(1):417, 2019
                                                              3. Aro K et al: Development of a novel salivary gland cancer lymph node staging system. Cancer. 124(15):3171-80, 2018
                                                              4. Aro K et al: Submandibular gland cancer: Specific features and treatment considerations. Head Neck. 40(1):154-62, 2018
                                                              5. Forner D et al: Secretory carcinoma: the eastern Canadian experience and literature review. J Otolaryngol Head Neck Surg. 47(1):69, 2018
                                                              6. Jang JY et al: Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer. BMC Cancer. 18(1):672, 2018
                                                              7. Szewczyk M et al: Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 23(4):260-5, 2018
                                                              8. Atula T et al: Preoperative evaluation and surgical planning of submandibular gland tumors. Head Neck. 39(6):1071-7, 2017
                                                              9. Amin MB et al: AJCC Cancer Staging Manual. 8th Ed. Springer New York, 2017
                                                              10. Gilbert MR et al: A 20-year review of 75 cases of salivary duct carcinoma. JAMA Otolaryngol Head Neck Surg. 142(5):489-95, 2016
                                                              11. Liu S et al: Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma. J Craniomaxillofac Surg. 42(8):1891-6, 2014
                                                              12. Ali S et al: Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. Ann Surg Oncol. 20(7):2396-404, 2013
                                                              13. Friedman ER et al: Pitfalls in the staging of cancer of the major salivary gland neoplasms. Neuroimaging Clin N Am. 23(1):107-22, 2013
                                                              14. Feinstein TM et al: Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy. Head Neck. 33(3):318-23, 2011
                                                              15. Guzzo M et al: Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 74(2):134-48, 2010
                                                              16. van der Schroeff MP et al: Cytology and histology have limited added value in prognostic models for salivary gland carcinomas. Oral Oncol. 46(9):662-6, 2010
                                                              17. Boukheris H et al: Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States. Cancer Epidemiol Biomarkers Prev. 18(11):2899-906, 2009
                                                              18. Nagliati M et al: Surgery and radiotherapy in the treatment of malignant parotid tumors: a retrospective multicenter study. Tumori. 95(4):442-8, 2009
                                                              19. Takahama Junior A et al: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol. 75(4):497-501, 2009
                                                              20. Moreno M et al: Sentinel lymph node biopsy in adenocarcinoma of minor salivary gland. Oral Oncol. 44(3):305-8, 2008
                                                              21. Subramaniam RM et al: F-18 FDG PET/CT imaging of submandibular gland oncocytoma. Clin Nucl Med. 33(7):472-4, 2008
                                                              22. Cermik TF et al: FDG PET in detecting primary and recurrent malignant salivary gland tumors. Clin Nucl Med. 32(4):286-91, 2007
                                                              23. de Ru JA et al: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg. 65(5):945-52, 2007
                                                              24. Roh JL et al: Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med. 48(2):240-6, 2007
                                                              25. Thoeny HC: Imaging of salivary gland tumours. Cancer Imaging. 7:52-62, 2007
                                                              26. Tincani AJ et al: Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series. Sao Paulo Med J. 124(1):26-30, 2006
                                                              27. Bell RB et al: Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg. 63(7):917-28, 2005
                                                              28. Fiorella R et al: Major salivary gland diseases. Multicentre study. Acta Otorhinolaryngol Ital. 2005 Jun;25(3):182-90. Erratum in: Acta Otorhinolaryngol Ital. 25(5):following 337, 2005
                                                              29. Witt RL: Major salivary gland cancer. Surg Oncol Clin N Am. 13(1):113-27, 2004