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Malakoplakia
Amir A. Borhani, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Malacoplakia = soft plaque
              • Definitions

                • Rare chronic granulomatous condition affecting urinary tract; thought to be due to altered host response and defective phagocytosis

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Stamatiou K et al: Renal failure caused by malakoplakia lesions of the urinary bladder. Nephrourol Mon. 6(4):e18522, 2014
                                      2. Sanchez LM et al: Malacoplakia presenting with obstructive nephropathy with bilateral ureter involvement. Nat Rev Nephrol. 5(7):418-22, 2009
                                      3. Wang J et al: Transitional cell carcinoma of upper urinary tract vs. benign lesions: distinctive MSCT features. Abdom Imaging. 34(1):94-106, 2009
                                      4. Wong-You-Cheong JJ et al: From the archives of the AFIP: Inflammatory and nonneoplastic bladder masses: radiologic-pathologic correlation. Radiographics. 26(6):1847-68, 2006
                                      5. Steele B et al: Sonographic appearance of bladder malacoplakia. Pediatr Radiol. 33(4):253-5, 2003
                                      6. Gumus E et al: Extensive bilateral renal pelvis, ureter and bladder leukoplakia. Int J Urol. 9(11):653-5, 2002
                                      7. Baumgartner BR et al: Malakoplakia of the ureter and bladder. Urol Radiol. 12(3):157-9, 1990
                                      8. Long JP Jr et al: Malacoplakia: a 25-year experience with a review of the literature. J Urol. 141(6):1328-31, 1989
                                      9. Bidwell JK et al: Computed tomography of bladder malakoplakia. J Comput Assist Tomogr. 11(5):909-10, 1987
                                      10. Curran FT: Malakoplakia of the bladder. Br J Urol. 59(6):559-63, 1987
                                      11. Arap S et al: Malakoplakia of the urinary tract. Eur Urol. 12(2):113-6, 1986
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Malacoplakia = soft plaque
                                                  • Definitions

                                                    • Rare chronic granulomatous condition affecting urinary tract; thought to be due to altered host response and defective phagocytosis

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Gross Pathologic & Surgical Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Stamatiou K et al: Renal failure caused by malakoplakia lesions of the urinary bladder. Nephrourol Mon. 6(4):e18522, 2014
                                                                          2. Sanchez LM et al: Malacoplakia presenting with obstructive nephropathy with bilateral ureter involvement. Nat Rev Nephrol. 5(7):418-22, 2009
                                                                          3. Wang J et al: Transitional cell carcinoma of upper urinary tract vs. benign lesions: distinctive MSCT features. Abdom Imaging. 34(1):94-106, 2009
                                                                          4. Wong-You-Cheong JJ et al: From the archives of the AFIP: Inflammatory and nonneoplastic bladder masses: radiologic-pathologic correlation. Radiographics. 26(6):1847-68, 2006
                                                                          5. Steele B et al: Sonographic appearance of bladder malacoplakia. Pediatr Radiol. 33(4):253-5, 2003
                                                                          6. Gumus E et al: Extensive bilateral renal pelvis, ureter and bladder leukoplakia. Int J Urol. 9(11):653-5, 2002
                                                                          7. Baumgartner BR et al: Malakoplakia of the ureter and bladder. Urol Radiol. 12(3):157-9, 1990
                                                                          8. Long JP Jr et al: Malacoplakia: a 25-year experience with a review of the literature. J Urol. 141(6):1328-31, 1989
                                                                          9. Bidwell JK et al: Computed tomography of bladder malakoplakia. J Comput Assist Tomogr. 11(5):909-10, 1987
                                                                          10. Curran FT: Malakoplakia of the bladder. Br J Urol. 59(6):559-63, 1987
                                                                          11. Arap S et al: Malakoplakia of the urinary tract. Eur Urol. 12(2):113-6, 1986