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Malignant Fibrous Histiocytoma of Bone
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Malignant fibrous histiocytoma (MFH)
          • Synonyms

            • Malignant histiocytoma, xanthosarcoma, malignant fibrous xanthoma, fibroxanthosarcoma
          • Definitions

            • Malignant osseous neoplasm composed of fibroblasts and pleomorphic cells exhibiting storiform pattern

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
                                        2. Romeo S et al: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 461(5):561-70, 2012
                                        3. Koplas MC et al: Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. Skeletal Radiol. 39(8):791-8, 2010
                                        4. Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
                                        5. Min WK et al: Malignant fibrous histiocytoma arising in the area of total hip replacement. Joint Bone Spine. 75(3):319-21, 2008
                                        6. Hoshi M et al: Malignant change secondary to fibrous dysplasia. Int J Clin Oncol. 11(3):229-35, 2006
                                        7. Richter H et al: Malignant fibrous histiocytoma associated with remote internal fixation of an ankle fracture. Foot Ankle Int. 27(5):375-9, 2006
                                        8. Scottish Bone Tumor Registry et al: Paget sarcoma of the spine: Scottish Bone Tumor Registry experience. Spine (Phila Pa 1976). 31(12):1344-50, 2006
                                        9. Staals EL et al: Dedifferentiated central chondrosarcoma. Cancer. 106(12):2682-91, 2006
                                        10. Tarkkanen M et al: Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. Eur J Cancer. 42(8):1172-80, 2006
                                        11. Visuri T et al: Malignant tumors at the site of total hip prosthesis. Analytic review of 46 cases. J Arthroplasty. 21(3):311-23, 2006
                                        12. Zlowodzki M et al: CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. Clin Orthop Relat Res. 439:269-73, 2005
                                        13. Steiner GC et al: Malignant Fibrous Histiocytoma of Bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 294-6, 2002
                                        14. Murphey MD et al: From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics. 14(4):807-26; quiz 827-8, 1994
                                        15. Yokoyama R et al: Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. Cancer. 72(6):1902-8, 1993
                                        16. Torres FX et al: Bone infarct-associated osteosarcoma. Cancer. 70(10):2418-30, 1992
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Malignant fibrous histiocytoma (MFH)
                                                • Synonyms

                                                  • Malignant histiocytoma, xanthosarcoma, malignant fibrous xanthoma, fibroxanthosarcoma
                                                • Definitions

                                                  • Malignant osseous neoplasm composed of fibroblasts and pleomorphic cells exhibiting storiform pattern

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Qu N et al: Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review. Medicine (Baltimore). 94(3):e369, 2015
                                                                              2. Romeo S et al: Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 461(5):561-70, 2012
                                                                              3. Koplas MC et al: Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. Skeletal Radiol. 39(8):791-8, 2010
                                                                              4. Domson GF et al: Infarct-associated bone sarcomas. Clin Orthop Relat Res. 467(7):1820-5, 2009
                                                                              5. Min WK et al: Malignant fibrous histiocytoma arising in the area of total hip replacement. Joint Bone Spine. 75(3):319-21, 2008
                                                                              6. Hoshi M et al: Malignant change secondary to fibrous dysplasia. Int J Clin Oncol. 11(3):229-35, 2006
                                                                              7. Richter H et al: Malignant fibrous histiocytoma associated with remote internal fixation of an ankle fracture. Foot Ankle Int. 27(5):375-9, 2006
                                                                              8. Scottish Bone Tumor Registry et al: Paget sarcoma of the spine: Scottish Bone Tumor Registry experience. Spine (Phila Pa 1976). 31(12):1344-50, 2006
                                                                              9. Staals EL et al: Dedifferentiated central chondrosarcoma. Cancer. 106(12):2682-91, 2006
                                                                              10. Tarkkanen M et al: Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. Eur J Cancer. 42(8):1172-80, 2006
                                                                              11. Visuri T et al: Malignant tumors at the site of total hip prosthesis. Analytic review of 46 cases. J Arthroplasty. 21(3):311-23, 2006
                                                                              12. Zlowodzki M et al: CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. Clin Orthop Relat Res. 439:269-73, 2005
                                                                              13. Steiner GC et al: Malignant Fibrous Histiocytoma of Bone. In Fletcher CDM et al: World Health Organization Classification of Tumours: Tumours of Soft Tissue and Bone. Lyon: IARC Press. 294-6, 2002
                                                                              14. Murphey MD et al: From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics. 14(4):807-26; quiz 827-8, 1994
                                                                              15. Yokoyama R et al: Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. Cancer. 72(6):1902-8, 1993
                                                                              16. Torres FX et al: Bone infarct-associated osteosarcoma. Cancer. 70(10):2418-30, 1992