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Malignant Peripheral Nerve Sheath Tumor of Head and Neck
Hilda E. Stambuk, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Malignant peripheral nerve sheath tumor (MPNST)
            • Synonyms

              • Neurogenic sarcoma, malignant schwannoma, malignant neurolemmoma, neurofibrosarcoma
            • Definitions

              • Malignant tumor of Schwann cell or other nerve sheath cell origin

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Broski SM et al: Evaluation of (18)F-FDG PET and MRI in differentiating benign and malignant peripheral nerve sheath tumors. Skeletal Radiol. 45(8):1097-105, 2016
                                          2. Patel TD et al: Comparative analysis of head and neck and non-head and neck malignant peripheral nerve sheath tumors. Otolaryngol Head Neck Surg. 154(1):113-20, 2016
                                          3. Arshi A et al: Malignant peripheral nerve sheath tumors of the head and neck: Demographics, clinicopathologic features, management, and treatment outcomes. Oral Oncol. 51(12):1088-94, 2015
                                          4. Soldatos T et al: Advanced MR imaging of peripheral nerve sheath tumors including diffusion imaging. Semin Musculoskelet Radiol. 19(2):179-90, 2015
                                          5. Zhang Z et al: MR imaging differentiation of malignant soft tissue tumors from peripheral schwannomas with large size and heterogeneous signal intensity. Eur J Radiol. 84(5):940-6, 2015
                                          6. Ahlawat S et al: Magnetic resonance neurography of peripheral nerve tumors and tumorlike conditions. Neuroimaging Clin N Am. 24(1):171-92, 2014
                                          7. Khiewvan B et al: The value of ¹⁸F-FDG PET/CT in the management of malignant peripheral nerve sheath tumors. Eur J Nucl Med Mol Imaging. 41(9):1756-66, 2014
                                          8. Wasa J et al: MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74, 2010
                                          9. Beegun I et al: Malignant peripheral nerve sheath tumours of the infraorbital nerve: case report and literature review. J Laryngol Otol. 123(4):466-70, 2009
                                          10. Wu JS et al: Soft-tissue tumors and tumorlike lesions: a systematic imaging approach. Radiology. 253(2):297-316, 2009
                                          11. Grobmyer SR et al: Malignant peripheral nerve Sheath tumor: molecular pathogenesis and current management considerations. J Surg Oncol. 97(4):340-9, 2008
                                          12. Gupta G et al: Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 19(4):533-43, v, 2008
                                          13. Hara M et al: Malignant peripheral nerve sheath tumor with Horner's syndrome: a case report. Ann Thorac Cardiovasc Surg. 14(4):246-8, 2008
                                          14. Das S et al: Tumors of the brachial plexus. Neurosurg Focus. 22(6):E26, 2007
                                          15. Singh T et al: Imaging of peripheral nerve tumors. Neurosurg Focus. 22(6):E6, 2007
                                          16. Martin-Duverneuil N et al: Facial malignant peripheral nerve sheath tumors. J Neuroradiol. 33(4):237-49, 2006
                                          17. Martinez Devesa P et al: Malignant peripheral nerve sheath tumors of the head and neck: two cases and a review of the literature. Ear Nose Throat J. 85(6):392-6, 2006
                                          18. Mrugala MM et al: Peripheral and cranial nerve sheath tumors. Curr Opin Neurol. 18(5):604-10, 2005
                                          19. Perrin RG et al: Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 15(2):203-16, 2004
                                          20. Lyons CJ et al: Orbital malignant peripheral nerve sheath tumours. Br J Ophthalmol. 73(9):731-8, 1989
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Malignant peripheral nerve sheath tumor (MPNST)
                                                    • Synonyms

                                                      • Neurogenic sarcoma, malignant schwannoma, malignant neurolemmoma, neurofibrosarcoma
                                                    • Definitions

                                                      • Malignant tumor of Schwann cell or other nerve sheath cell origin

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Broski SM et al: Evaluation of (18)F-FDG PET and MRI in differentiating benign and malignant peripheral nerve sheath tumors. Skeletal Radiol. 45(8):1097-105, 2016
                                                                                  2. Patel TD et al: Comparative analysis of head and neck and non-head and neck malignant peripheral nerve sheath tumors. Otolaryngol Head Neck Surg. 154(1):113-20, 2016
                                                                                  3. Arshi A et al: Malignant peripheral nerve sheath tumors of the head and neck: Demographics, clinicopathologic features, management, and treatment outcomes. Oral Oncol. 51(12):1088-94, 2015
                                                                                  4. Soldatos T et al: Advanced MR imaging of peripheral nerve sheath tumors including diffusion imaging. Semin Musculoskelet Radiol. 19(2):179-90, 2015
                                                                                  5. Zhang Z et al: MR imaging differentiation of malignant soft tissue tumors from peripheral schwannomas with large size and heterogeneous signal intensity. Eur J Radiol. 84(5):940-6, 2015
                                                                                  6. Ahlawat S et al: Magnetic resonance neurography of peripheral nerve tumors and tumorlike conditions. Neuroimaging Clin N Am. 24(1):171-92, 2014
                                                                                  7. Khiewvan B et al: The value of ¹⁸F-FDG PET/CT in the management of malignant peripheral nerve sheath tumors. Eur J Nucl Med Mol Imaging. 41(9):1756-66, 2014
                                                                                  8. Wasa J et al: MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74, 2010
                                                                                  9. Beegun I et al: Malignant peripheral nerve sheath tumours of the infraorbital nerve: case report and literature review. J Laryngol Otol. 123(4):466-70, 2009
                                                                                  10. Wu JS et al: Soft-tissue tumors and tumorlike lesions: a systematic imaging approach. Radiology. 253(2):297-316, 2009
                                                                                  11. Grobmyer SR et al: Malignant peripheral nerve Sheath tumor: molecular pathogenesis and current management considerations. J Surg Oncol. 97(4):340-9, 2008
                                                                                  12. Gupta G et al: Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 19(4):533-43, v, 2008
                                                                                  13. Hara M et al: Malignant peripheral nerve sheath tumor with Horner's syndrome: a case report. Ann Thorac Cardiovasc Surg. 14(4):246-8, 2008
                                                                                  14. Das S et al: Tumors of the brachial plexus. Neurosurg Focus. 22(6):E26, 2007
                                                                                  15. Singh T et al: Imaging of peripheral nerve tumors. Neurosurg Focus. 22(6):E6, 2007
                                                                                  16. Martin-Duverneuil N et al: Facial malignant peripheral nerve sheath tumors. J Neuroradiol. 33(4):237-49, 2006
                                                                                  17. Martinez Devesa P et al: Malignant peripheral nerve sheath tumors of the head and neck: two cases and a review of the literature. Ear Nose Throat J. 85(6):392-6, 2006
                                                                                  18. Mrugala MM et al: Peripheral and cranial nerve sheath tumors. Curr Opin Neurol. 18(5):604-10, 2005
                                                                                  19. Perrin RG et al: Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 15(2):203-16, 2004
                                                                                  20. Lyons CJ et al: Orbital malignant peripheral nerve sheath tumours. Br J Ophthalmol. 73(9):731-8, 1989