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Malignant Peripheral Nerve Sheath Tumor
Terrance Healey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Neurofibromatosis type 1 (NF1)
              • Definitions

                • Malignant peripheral nerve sheath tumor (MPNST)
                  • Spindle cell sarcoma of nerve sheath origin

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Imaging Recommendations

                        • Nuclear Medicine Findings

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Gross Pathologic & Surgical Features

                                • Microscopic Features

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Abreu E et al: Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol. Epub ahead of print, 2011
                                              2. Nam SJ et al: Imaging of primary chest wall tumors with radiologic-pathologic correlation. Radiographics. 31(3):749-70, 2011
                                              3. Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
                                              4. Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
                                              5. Woertler K: Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol. 14(5):547-58, 2010
                                              6. Spitzer AL et al: Anatomic classification system for surgical management of paraspinal tumors. Arch Surg. 139(3):262-9, 2004
                                              7. Takeda S et al: Intrathoracic neurogenic tumors--50 years' experience in a Japanese institution. Eur J Cardiothorac Surg. 26(4):807-12, 2004
                                              8. Cardona S et al: Evaluation of F18-deoxyglucose positron emission tomography (FDG-PET) to assess the nature of neurogenic tumours. Eur J Surg Oncol. 29(6):536-41, 2003
                                              9. Erasmus JJ et al: MR imaging of mediastinal masses. Magn Reson Imaging Clin N Am. 8(1):59-89, 2000
                                              10. Reeder LB: Neurogenic tumors of the mediastinum. Semin Thorac Cardiovasc Surg. 12(4):261-7, 2000
                                              11. Lee JY et al: Spectrum of neurogenic tumors in the thorax: CT and pathologic findings. J Comput Assist Tomogr. 23(3):399-406, 1999
                                              12. Marchevsky AM: Mediastinal tumors of peripheral nervous system origin. Semin Diagn Pathol. 16(1):65-78, 1999
                                              13. Rossi SE et al: Thoracic manifestations of neurofibromatosis-I. AJR Am J Roentgenol. 173(6):1631-8, 1999
                                              14. Strollo DC et al: Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 112(5):1344-57, 1997
                                              15. Sakai F et al: Intrathoracic neurogenic tumors: MR-pathologic correlation. AJR Am J Roentgenol. 159(2):279-83, 1992
                                              16. Levine E et al: Malignant nerve-sheath neoplasms in neurofibromatosis: distinction from benign tumors by using imaging techniques. AJR Am J Roentgenol. 149(5):1059-64, 1987
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Abbreviations

                                                            • Neurofibromatosis type 1 (NF1)
                                                          • Definitions

                                                            • Malignant peripheral nerve sheath tumor (MPNST)
                                                              • Spindle cell sarcoma of nerve sheath origin

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Imaging Recommendations

                                                                    • Nuclear Medicine Findings

                                                                      DIFFERENTIAL DIAGNOSIS

                                                                        PATHOLOGY

                                                                        • General Features

                                                                          • Gross Pathologic & Surgical Features

                                                                            • Microscopic Features

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Abreu E et al: Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol. Epub ahead of print, 2011
                                                                                          2. Nam SJ et al: Imaging of primary chest wall tumors with radiologic-pathologic correlation. Radiographics. 31(3):749-70, 2011
                                                                                          3. Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
                                                                                          4. Wasa J, Nishida Y, Tsukushi S, et al. MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74., 2010
                                                                                          5. Woertler K: Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol. 14(5):547-58, 2010
                                                                                          6. Spitzer AL et al: Anatomic classification system for surgical management of paraspinal tumors. Arch Surg. 139(3):262-9, 2004
                                                                                          7. Takeda S et al: Intrathoracic neurogenic tumors--50 years' experience in a Japanese institution. Eur J Cardiothorac Surg. 26(4):807-12, 2004
                                                                                          8. Cardona S et al: Evaluation of F18-deoxyglucose positron emission tomography (FDG-PET) to assess the nature of neurogenic tumours. Eur J Surg Oncol. 29(6):536-41, 2003
                                                                                          9. Erasmus JJ et al: MR imaging of mediastinal masses. Magn Reson Imaging Clin N Am. 8(1):59-89, 2000
                                                                                          10. Reeder LB: Neurogenic tumors of the mediastinum. Semin Thorac Cardiovasc Surg. 12(4):261-7, 2000
                                                                                          11. Lee JY et al: Spectrum of neurogenic tumors in the thorax: CT and pathologic findings. J Comput Assist Tomogr. 23(3):399-406, 1999
                                                                                          12. Marchevsky AM: Mediastinal tumors of peripheral nervous system origin. Semin Diagn Pathol. 16(1):65-78, 1999
                                                                                          13. Rossi SE et al: Thoracic manifestations of neurofibromatosis-I. AJR Am J Roentgenol. 173(6):1631-8, 1999
                                                                                          14. Strollo DC et al: Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 112(5):1344-57, 1997
                                                                                          15. Sakai F et al: Intrathoracic neurogenic tumors: MR-pathologic correlation. AJR Am J Roentgenol. 159(2):279-83, 1992
                                                                                          16. Levine E et al: Malignant nerve-sheath neoplasms in neurofibromatosis: distinction from benign tumors by using imaging techniques. AJR Am J Roentgenol. 149(5):1059-64, 1987