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Malignant Pleural Effusion
Allen Heeger, DO
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Malignant pleural effusion (MPE)
              • Definitions

                • Exudate; neoplastic cells from pleural malignancy
                • Paramalignant effusion: Pleural effusion in malignancy
                  • Postobstructive atelectasis, pulmonary embolism, lymphatic/thoracic duct obstruction, superior vena cava obstruction, malignant pericardial effusion/tamponade, hypoalbuminemia, post treatment

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      • Ultrasonographic Findings

                        • Nuclear Medicine Findings

                          • Imaging Recommendations

                            DIFFERENTIAL DIAGNOSIS

                              PATHOLOGY

                              • General Features

                                • Staging, Grading, & Classification

                                  • Gross Pathologic & Surgical Features

                                    • Microscopic Features

                                      CLINICAL ISSUES

                                      • Presentation

                                        • Demographics

                                          • Natural History & Prognosis

                                            • Treatment

                                              DIAGNOSTIC CHECKLIST

                                              • Consider

                                                • Image Interpretation Pearls

                                                  Selected References

                                                  1. Jany B et al: Pleural effusion in adults-etiology, diagnosis, and treatment. Dtsch Arztebl Int. 116(21):377-86, 2019
                                                  2. Kaul V et al: Contemporary approach to the diagnosis of malignant pleural effusion. Ann Am Thorac Soc. 16(9):1099-106, 2019
                                                  3. Skok K et al: Malignant pleural effusion and its current management: a review. Medicina (Kaunas). 55(8), 2019
                                                  4. Wahla AS et al: Managing malignant pleural effusion. Cleve Clin J Med. 86(2):95-9, 2019
                                                  5. Asciak R et al: Malignant pleural effusion: from diagnostics to therapeutics. Clin Chest Med. 39(1):181-93, 2018
                                                  6. Abrao FC et al: Prognostic factors of 30-day mortality after palliative procedures in patients with malignant pleural effusion. Ann Surg Oncol. 22(12):4083-8, 2015
                                                  7. DeBiasi EM et al: Mortality among patients with pleural effusion undergoing thoracentesis. Eur Respir J. ;46(2):495-502, 2015
                                                  8. Porcel JM et al: Clinical features and survival of lung cancer patients with pleural effusions. Respirology. 20(4):654-9, 2015
                                                  9. Zamboni MM et al: Important prognostic factors for survival in patients with malignant pleural effusion. BMC Pulm Med. 15:29, 2015
                                                  Related Anatomy
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                                                  Related Differential Diagnoses
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                                                  References
                                                  Tables

                                                  Tables

                                                  KEY FACTS

                                                  • Terminology

                                                    • Imaging

                                                      • Top Differential Diagnoses

                                                        • Pathology

                                                          • Clinical Issues

                                                            • Diagnostic Checklist

                                                              TERMINOLOGY

                                                              • Abbreviations

                                                                • Malignant pleural effusion (MPE)
                                                              • Definitions

                                                                • Exudate; neoplastic cells from pleural malignancy
                                                                • Paramalignant effusion: Pleural effusion in malignancy
                                                                  • Postobstructive atelectasis, pulmonary embolism, lymphatic/thoracic duct obstruction, superior vena cava obstruction, malignant pericardial effusion/tamponade, hypoalbuminemia, post treatment

                                                              IMAGING

                                                              • General Features

                                                                • Radiographic Findings

                                                                  • CT Findings

                                                                    • MR Findings

                                                                      • Ultrasonographic Findings

                                                                        • Nuclear Medicine Findings

                                                                          • Imaging Recommendations

                                                                            DIFFERENTIAL DIAGNOSIS

                                                                              PATHOLOGY

                                                                              • General Features

                                                                                • Staging, Grading, & Classification

                                                                                  • Gross Pathologic & Surgical Features

                                                                                    • Microscopic Features

                                                                                      CLINICAL ISSUES

                                                                                      • Presentation

                                                                                        • Demographics

                                                                                          • Natural History & Prognosis

                                                                                            • Treatment

                                                                                              DIAGNOSTIC CHECKLIST

                                                                                              • Consider

                                                                                                • Image Interpretation Pearls

                                                                                                  Selected References

                                                                                                  1. Jany B et al: Pleural effusion in adults-etiology, diagnosis, and treatment. Dtsch Arztebl Int. 116(21):377-86, 2019
                                                                                                  2. Kaul V et al: Contemporary approach to the diagnosis of malignant pleural effusion. Ann Am Thorac Soc. 16(9):1099-106, 2019
                                                                                                  3. Skok K et al: Malignant pleural effusion and its current management: a review. Medicina (Kaunas). 55(8), 2019
                                                                                                  4. Wahla AS et al: Managing malignant pleural effusion. Cleve Clin J Med. 86(2):95-9, 2019
                                                                                                  5. Asciak R et al: Malignant pleural effusion: from diagnostics to therapeutics. Clin Chest Med. 39(1):181-93, 2018
                                                                                                  6. Abrao FC et al: Prognostic factors of 30-day mortality after palliative procedures in patients with malignant pleural effusion. Ann Surg Oncol. 22(12):4083-8, 2015
                                                                                                  7. DeBiasi EM et al: Mortality among patients with pleural effusion undergoing thoracentesis. Eur Respir J. ;46(2):495-502, 2015
                                                                                                  8. Porcel JM et al: Clinical features and survival of lung cancer patients with pleural effusions. Respirology. 20(4):654-9, 2015
                                                                                                  9. Zamboni MM et al: Important prognostic factors for survival in patients with malignant pleural effusion. BMC Pulm Med. 15:29, 2015