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Head and Neck
Diagnosis
Mandible-Maxilla
Tumor-like Lesions
Mandible-Maxilla Fibrous Dysplasia
Mandible-Maxilla Fibrous Dysplasia
C. Grace Petrikowski, DDS, MSc, FRCD(C); Dania Tamimi, BDS, DMSc
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Fibrous dysplasia (FD)

            • Synonyms

              • Osteitis fibrosa, osteodystrophia fibrosa, fibrous osteoma, fibrous osteodysplasia

            • Definitions

              • Benign fibroosseous disease
              • Replacement of normal cancellous bone with cellular fibrous tissue containing foci of immature woven bone

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • CT Findings

                    • MR Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Atalar MH et al: CT and MR imaging in a large series of patients with craniofacial fibrous dysplasia. Pol J Radiol. 80:232-40, 2015
                                              2. Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
                                              3. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                              4. Wu H et al: Clinical characteristics of craniomaxillofacial fibrous dysplasia. J Craniomaxillofac Surg. 42(7):1450-5, 2014
                                              5. Akintoye SO et al: Dental perspectives in fibrous dysplasia and McCune-Albright syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(3):e149-55, 2013
                                              6. Cheng J et al: Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia. J Craniofac Surg. 24(1):141-5, 2013
                                              7. DeKlotz TR et al: Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright syndrome. Laryngoscope. 123(4):823-8, 2013
                                              8. Hanifi B et al: Craniofacial fibrous dysplasia. Clin Imaging. 37(6):1109-15, 2013
                                              9. Kurra S et al: Fibrous dysplasia and central giant cell granuloma: a report of hybrid lesion with its review and hypotheticated pathogenesis. J Clin Diagn Res. 7(5):954-8, 2013
                                              10. Menon S et al: Craniofacial fibrous dysplasia: surgery and literature review. Ann Maxillofac Surg. 3(1):66-71, 2013
                                              11. Nadaf A et al: Monostostic fibrous dysplasia with nonspecific cystic degeneration: A case report and review of literature. J Oral Maxillofac Pathol. 17(2):274-80, 2013
                                              12. Collins MT et al: McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia. Orphanet J Rare Dis. 7 Suppl 1:S4, 2012
                                              13. Sontakke SA et al: Computed tomographic features of fibrous dysplasia of maxillofacial region. Imaging Sci Dent. 41(1):23-8, 2011
                                              14. Kanazawa I et al: Osteosarcoma in a pregnant patient with McCune-Albright syndrome. Bone. 45(3):603-8, 2009
                                              15. MacDonald-Jankowski D: Fibrous dysplasia: a systematic review. Dentomaxillofac Radiol. 38(4):196-215, 2009
                                              16. Macdonald-Jankowski DS et al: Fibrous dysplasia in a Hong Kong community: the clinical and radiological features and outcomes of treatment. Dentomaxillofac Radiol. 38(2):63-72, 2009
                                              17. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 2004 Jan;59(1):11-25. Review. Erratum in: Clin Radiol. 64(1):107, 2009
                                              18. Cappabianca S et al: Maxillofacial fibrous dysplasia: personal experience with gadoliniumenhanced magnetic resonance imaging. Radiol Med. 113(8):1198-210, 2008
                                              19. MacDonald-Jankowski DS et al: Computed tomography of fibrous dysplasia. Dentomaxillofac Radiol. 33(2):114-8, 2004
                                              20. Lustig LR et al: Fibrous dysplasia involving the skull base and temporal bone. Arch Otolaryngol Head Neck Surg. 127(10):1239-47, 2001
                                              21. Ferretti C et al: Cystic degeneration in fibrous dysplasia of the jaws: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88(3):337-42, 1999
                                              22. Petrikowski CG et al: Radiographic differentiation of osteogenic sarcoma, osteomyelitis, and fibrous dysplasia of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 80(6):744-50, 1995
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Pathology

                                                      • Clinical Issues

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Fibrous dysplasia (FD)

                                                        • Synonyms

                                                          • Osteitis fibrosa, osteodystrophia fibrosa, fibrous osteoma, fibrous osteodysplasia

                                                        • Definitions

                                                          • Benign fibroosseous disease
                                                          • Replacement of normal cancellous bone with cellular fibrous tissue containing foci of immature woven bone

                                                        IMAGING

                                                        • General Features

                                                          • Imaging Recommendations

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Atalar MH et al: CT and MR imaging in a large series of patients with craniofacial fibrous dysplasia. Pol J Radiol. 80:232-40, 2015
                                                                                          2. Muthusamy S et al: Locally aggressive fibrous dysplasia mimicking malignancy: a report of four cases and review of the literature. Clin Orthop Relat Res. 473(2):742-50, 2015
                                                                                          3. Bousson V et al: Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 83(10):1828-42, 2014
                                                                                          4. Wu H et al: Clinical characteristics of craniomaxillofacial fibrous dysplasia. J Craniomaxillofac Surg. 42(7):1450-5, 2014
                                                                                          5. Akintoye SO et al: Dental perspectives in fibrous dysplasia and McCune-Albright syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(3):e149-55, 2013
                                                                                          6. Cheng J et al: Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia. J Craniofac Surg. 24(1):141-5, 2013
                                                                                          7. DeKlotz TR et al: Sinonasal disease in polyostotic fibrous dysplasia and McCune-Albright syndrome. Laryngoscope. 123(4):823-8, 2013
                                                                                          8. Hanifi B et al: Craniofacial fibrous dysplasia. Clin Imaging. 37(6):1109-15, 2013
                                                                                          9. Kurra S et al: Fibrous dysplasia and central giant cell granuloma: a report of hybrid lesion with its review and hypotheticated pathogenesis. J Clin Diagn Res. 7(5):954-8, 2013
                                                                                          10. Menon S et al: Craniofacial fibrous dysplasia: surgery and literature review. Ann Maxillofac Surg. 3(1):66-71, 2013
                                                                                          11. Nadaf A et al: Monostostic fibrous dysplasia with nonspecific cystic degeneration: A case report and review of literature. J Oral Maxillofac Pathol. 17(2):274-80, 2013
                                                                                          12. Collins MT et al: McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia. Orphanet J Rare Dis. 7 Suppl 1:S4, 2012
                                                                                          13. Sontakke SA et al: Computed tomographic features of fibrous dysplasia of maxillofacial region. Imaging Sci Dent. 41(1):23-8, 2011
                                                                                          14. Kanazawa I et al: Osteosarcoma in a pregnant patient with McCune-Albright syndrome. Bone. 45(3):603-8, 2009
                                                                                          15. MacDonald-Jankowski D: Fibrous dysplasia: a systematic review. Dentomaxillofac Radiol. 38(4):196-215, 2009
                                                                                          16. Macdonald-Jankowski DS et al: Fibrous dysplasia in a Hong Kong community: the clinical and radiological features and outcomes of treatment. Dentomaxillofac Radiol. 38(2):63-72, 2009
                                                                                          17. MacDonald-Jankowski DS: Fibro-osseous lesions of the face and jaws. Clin Radiol. 2004 Jan;59(1):11-25. Review. Erratum in: Clin Radiol. 64(1):107, 2009
                                                                                          18. Cappabianca S et al: Maxillofacial fibrous dysplasia: personal experience with gadoliniumenhanced magnetic resonance imaging. Radiol Med. 113(8):1198-210, 2008
                                                                                          19. MacDonald-Jankowski DS et al: Computed tomography of fibrous dysplasia. Dentomaxillofac Radiol. 33(2):114-8, 2004
                                                                                          20. Lustig LR et al: Fibrous dysplasia involving the skull base and temporal bone. Arch Otolaryngol Head Neck Surg. 127(10):1239-47, 2001
                                                                                          21. Ferretti C et al: Cystic degeneration in fibrous dysplasia of the jaws: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88(3):337-42, 1999
                                                                                          22. Petrikowski CG et al: Radiographic differentiation of osteogenic sarcoma, osteomyelitis, and fibrous dysplasia of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 80(6):744-50, 1995