Group of lesions affecting reticuloendothelial system and characterized by proliferation of Langerhans cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Azariah ED et al: "Histiocytosis X" - a rare case report. J Clin Diagn Res. 10(10):ZD19-ZD22, 2016
Gambirazi L et al: Diagnosis and intralesional corticotherapy in oral ulcers occurring as the sole manifestation of Langerhans cell histiocytosis. A Case Report. Open Dent J. 10:330-7, 2016
Plona GA et al: Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. Oral Surg Oral Med Oral Pathol Oral Radiol. 122(2):e60-3, 2016
Agarwal P et al: An unusual presentation of Langerhans cell histiocytosis. J Cytol. 31(4):227-9, 2014
Shi S et al: Multifocal Langerhans cell histiocytosis in an adult with a pathological fracture of the mandible and spontaneous malunion: A case report. Oncol Lett. 8(3):1075-1079, 2014
Cho YA et al: Hypothetical pathogenesis of eosinophilic infiltration in Langerhans cell histiocytosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(6):734-42, 2013
Lee BD et al: Eosinophilic granuloma in the anterior mandible mimicking radicular cyst. Imaging Sci Dent. 43(2):117-22, 2013
Lee SH et al: Intralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(4):e255-60, 2013
Zajko J: Mandibular Langerhans cell histiocytosis in an adult. Bratisl Lek Listy. 114(8):488-90, 2013
Ge Y et al: [Langerhans cell histiocytosis: a case report.] Hua Xi Kou Qiang Yi Xue Za Zhi. 30(5):554-6, 2012
Lajolo C et al: Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature. Gerodontology. 29(2):e1207-14, 2012
Parihar A et al: Management of polyostotic eosinophilic granuloma. Dent Res J (Isfahan). 9(6):821-5, 2012
Yepes JF et al: Chronic focal Langerhans cell histiocytosis of the left mandibular condyle presenting as limited jaw opening: a case report. Ear Nose Throat J. 91(10):E26-30, 2012
Murray M et al: Multifocal oral Langerhans cell histiocytosis. J Oral Maxillofac Surg. 69(10):2585-91, 2011
Noonan V et al: Langerhans cell histiocytosis (eosinophilic granuloma). J Mass Dent Soc. 60(2):35, 2011
Zhao Y et al: [The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis.] Hua Xi Kou Qiang Yi Xue Za Zhi. 29(6):604-9, 2011
Altug HA et al: Incidental discovery of asymptomatic radiolucent lesion of the posterior mandible. J Oral Maxillofac Surg. 68(4):845-8, 2010
Esen A et al: Treatment of localized Langerhans' cell histiocytosis of the mandible with intralesional steroid injection: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109(2):e53-8, 2010
Neville B et al: Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders, 2009
Muramatsu T et al: Clinico-pathologic conference: case 4. Langerhans cell histiocytosis (LCH). Head Neck Pathol. 4(4):343-6, 2010
Jalil Ab et al: Oral Langerhans cell histiocytosis in Malaysian children: a 40-year experience. Int J Paediatr Dent. 19(5):349-53, 2009
Rees J et al: Langerhans cell histiocytosis in an adult. Br J Oral Maxillofac Surg. 47(1):52-3, 2009
Baltacioğlu E et al: Clinical, pathological and radiological evaluation of disseminated Langerhans' cell histiocytosis in a 30-month-old boy. Dentomaxillofac Radiol. 36(8):526-9, 2007
dos Anjos Pontual ML et al: Eosinophilic granuloma in the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(6):e47-51, 2007
Ramani P et al: Langerhans cell histiocytosis of the mandible in a six-year-old child. Indian J Dermatol Venereol Leprol. 73(2):114-6, 2007
Schroff J. Eosinophilic granuloma of bone: case report of eosinophilic granuloma of mouth (jaws et al: 1948. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100(2 Suppl):S37-41, 2005
Eckardt A et al: Maxillofacial manifestations of Langerhans cell histiocytosis: a clinical and therapeutic analysis of 10 patients. Oral Oncol. 39(7):687-94, 2003
Siessegger M et al: Monolocular Langerhans cell histiocytosis of the mandibular condyle. A case report. Br J Oral Maxillofac Surg. 40(6):516-8, 2002
Kessler P et al: Langerhans cell granulomatosis: a case report of polyostotic manifestation in the jaw. Int J Oral Maxillofac Surg. 30(4):359-61, 2001
Loducca SV et al: Langerhans cell histiocytosis: recurrent lesions affecting mandible in a 10-year-old patient. J Clin Pediatr Dent. 25(3):241-3, 2001
Namai T et al: Spontaneous remission of a solitary eosinophilic granuloma of the mandible after biopsy: a case report. J Oral Maxillofac Surg. 59(12):1485-7, 2001
Asaumi J et al: Two cases of polyostotic eosinophilic granuloma. Dentomaxillofac Radiol. 29(6):382-5, 2000
Miyamoto H et al: Eosinophilic granuloma of the mandibular condyle. J Oral Maxillofac Surg. 58(5):560-2, 2000
Watzke IM et al: Multifocal eosinophilic granuloma of the jaw: long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90(3):317-22, 2000
Ardekian L et al: Clinical and radiographic features of eosinophilic granuloma in the jaws: review of 41 lesions treated by surgery and low-dose radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 87(2):238-42, 1999
Saunders JG et al: Langerhans cell histiocytosis presenting as bilateral eosinophilic granulomata in the molar region of the mandible. A case report. J Clin Periodontol. 25(4):340-2, 1998
Wong GB et al: Eosinophilic granuloma of the mandibular condyle: report of three cases and review of the literature. J Oral Maxillofac Surg. 55(8):870-8, 1997
Uckan S et al: Recurrent multifocal Langerhans cell eosinophilic granuloma of the jaws: report of a case. J Oral Maxillofac Surg. 54(7):906-9, 1996
Group of lesions affecting reticuloendothelial system and characterized by proliferation of Langerhans cells
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Azariah ED et al: "Histiocytosis X" - a rare case report. J Clin Diagn Res. 10(10):ZD19-ZD22, 2016
Gambirazi L et al: Diagnosis and intralesional corticotherapy in oral ulcers occurring as the sole manifestation of Langerhans cell histiocytosis. A Case Report. Open Dent J. 10:330-7, 2016
Plona GA et al: Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. Oral Surg Oral Med Oral Pathol Oral Radiol. 122(2):e60-3, 2016
Agarwal P et al: An unusual presentation of Langerhans cell histiocytosis. J Cytol. 31(4):227-9, 2014
Shi S et al: Multifocal Langerhans cell histiocytosis in an adult with a pathological fracture of the mandible and spontaneous malunion: A case report. Oncol Lett. 8(3):1075-1079, 2014
Cho YA et al: Hypothetical pathogenesis of eosinophilic infiltration in Langerhans cell histiocytosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(6):734-42, 2013
Lee BD et al: Eosinophilic granuloma in the anterior mandible mimicking radicular cyst. Imaging Sci Dent. 43(2):117-22, 2013
Lee SH et al: Intralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(4):e255-60, 2013
Zajko J: Mandibular Langerhans cell histiocytosis in an adult. Bratisl Lek Listy. 114(8):488-90, 2013
Ge Y et al: [Langerhans cell histiocytosis: a case report.] Hua Xi Kou Qiang Yi Xue Za Zhi. 30(5):554-6, 2012
Lajolo C et al: Langerhans's cell histiocytosis in old subjects: two rare case reports and review of the literature. Gerodontology. 29(2):e1207-14, 2012
Parihar A et al: Management of polyostotic eosinophilic granuloma. Dent Res J (Isfahan). 9(6):821-5, 2012
Yepes JF et al: Chronic focal Langerhans cell histiocytosis of the left mandibular condyle presenting as limited jaw opening: a case report. Ear Nose Throat J. 91(10):E26-30, 2012
Murray M et al: Multifocal oral Langerhans cell histiocytosis. J Oral Maxillofac Surg. 69(10):2585-91, 2011
Noonan V et al: Langerhans cell histiocytosis (eosinophilic granuloma). J Mass Dent Soc. 60(2):35, 2011
Zhao Y et al: [The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis.] Hua Xi Kou Qiang Yi Xue Za Zhi. 29(6):604-9, 2011
Altug HA et al: Incidental discovery of asymptomatic radiolucent lesion of the posterior mandible. J Oral Maxillofac Surg. 68(4):845-8, 2010
Esen A et al: Treatment of localized Langerhans' cell histiocytosis of the mandible with intralesional steroid injection: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109(2):e53-8, 2010
Neville B et al: Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders, 2009
Muramatsu T et al: Clinico-pathologic conference: case 4. Langerhans cell histiocytosis (LCH). Head Neck Pathol. 4(4):343-6, 2010
Jalil Ab et al: Oral Langerhans cell histiocytosis in Malaysian children: a 40-year experience. Int J Paediatr Dent. 19(5):349-53, 2009
Rees J et al: Langerhans cell histiocytosis in an adult. Br J Oral Maxillofac Surg. 47(1):52-3, 2009
Baltacioğlu E et al: Clinical, pathological and radiological evaluation of disseminated Langerhans' cell histiocytosis in a 30-month-old boy. Dentomaxillofac Radiol. 36(8):526-9, 2007
dos Anjos Pontual ML et al: Eosinophilic granuloma in the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(6):e47-51, 2007
Ramani P et al: Langerhans cell histiocytosis of the mandible in a six-year-old child. Indian J Dermatol Venereol Leprol. 73(2):114-6, 2007
Schroff J. Eosinophilic granuloma of bone: case report of eosinophilic granuloma of mouth (jaws et al: 1948. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100(2 Suppl):S37-41, 2005
Eckardt A et al: Maxillofacial manifestations of Langerhans cell histiocytosis: a clinical and therapeutic analysis of 10 patients. Oral Oncol. 39(7):687-94, 2003
Siessegger M et al: Monolocular Langerhans cell histiocytosis of the mandibular condyle. A case report. Br J Oral Maxillofac Surg. 40(6):516-8, 2002
Kessler P et al: Langerhans cell granulomatosis: a case report of polyostotic manifestation in the jaw. Int J Oral Maxillofac Surg. 30(4):359-61, 2001
Loducca SV et al: Langerhans cell histiocytosis: recurrent lesions affecting mandible in a 10-year-old patient. J Clin Pediatr Dent. 25(3):241-3, 2001
Namai T et al: Spontaneous remission of a solitary eosinophilic granuloma of the mandible after biopsy: a case report. J Oral Maxillofac Surg. 59(12):1485-7, 2001
Asaumi J et al: Two cases of polyostotic eosinophilic granuloma. Dentomaxillofac Radiol. 29(6):382-5, 2000
Miyamoto H et al: Eosinophilic granuloma of the mandibular condyle. J Oral Maxillofac Surg. 58(5):560-2, 2000
Watzke IM et al: Multifocal eosinophilic granuloma of the jaw: long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 90(3):317-22, 2000
Ardekian L et al: Clinical and radiographic features of eosinophilic granuloma in the jaws: review of 41 lesions treated by surgery and low-dose radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 87(2):238-42, 1999
Saunders JG et al: Langerhans cell histiocytosis presenting as bilateral eosinophilic granulomata in the molar region of the mandible. A case report. J Clin Periodontol. 25(4):340-2, 1998
Wong GB et al: Eosinophilic granuloma of the mandibular condyle: report of three cases and review of the literature. J Oral Maxillofac Surg. 55(8):870-8, 1997
Uckan S et al: Recurrent multifocal Langerhans cell eosinophilic granuloma of the jaws: report of a case. J Oral Maxillofac Surg. 54(7):906-9, 1996
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