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Mandible-Maxilla Nerve Sheath Tumor
Lisa J. Koenig, BChD, DDS, MS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Schwannoma: Neurilemmoma, peripheral fibroblastoma, neurinoma
                • Neurofibroma (NF): Neurinoma
              • Definitions

                • Benign perineural tumor arising from cells of neural sheath
                  • Schwannoma: Arises from Schwann cells and displaces axons
                    • Schwann cells cover myelinated nerves
                  • NF: Mixture of Schwann cells and perineural cells that incorporate axons
                • Malignant peripheral nerve sheath tumor
                  • Most commonly involves major nerve trunks, including brachial plexus

              IMAGING

              • General Features

                • Radiographic Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Majumdar S et al: Malignant peripheral nerve sheath tumor -a rare malignancy in mandible. J Clin Diagn Res. 10(6):ZD12-3, 2016
                                          2. Noonan V et al: Enlargement of the inferior alveolar canal. J Mass Dent Soc. 64(4):37, 2016
                                          3. Meundi MA et al: Intraosseous schwannoma of the maxilla mimicking a periapical lesion: a diagnostic challenge. J Clin Diagn Res. 9(3):ZD01-4, 2015
                                          4. Patel S et al: Malignant peripheral nerve sheath tumour (MPNST) of mandible: solving the perplexity. BMJ Case Rep. 2015, 2015
                                          5. Yin Y et al: Microcystic/reticular schwannoma of the mandible first case report and review of the literature. Medicine (Baltimore). 94(45):e1974, 2015
                                          6. Aboh IV et al: Giant palatal schwannoma. J Craniofac Surg. 25(5):e418-20, 2014
                                          7. Jain D et al: Neurofibroma of the maxillary antrum: a rare case. Contemp Clin Dent. 5(1):115-8, 2014
                                          8. Jangam SS et al: Solitary intraosseous neurofibroma: report of a unique case. Contemp Clin Dent. 5(4):561-3, 2014
                                          9. Naina P et al: Infraorbital nerve schwannoma: a rare cause of upper jaw swelling. Indian J Dent Res. 25(2):263-5, 2014
                                          10. Bodner L et al: [Introsseous schwannoma of the mandible.] Fogorv Sz. 106(4):131-4, 2013
                                          11. da Rosa MR et al: Solitary giant neurofibroma of the mental nerve: a trauma-related lesion? J Craniofac Surg. 24(3):e247-51, 2013
                                          12. Lambade PN et al: Unusual intramaxillary plexiform schwannoma. Oral Maxillofac Surg. 17(2):137-40, 2013
                                          13. Suga K et al: Intraosseous schwannoma originating in inferior alveolar nerve: a case report. Bull Tokyo Dent Coll. 54(1):19-25, 2013
                                          14. Vuity D et al: [A 40 year old palatal neurofibroma. A case report.] Fogorv Sz. 106(1):3-6, 2013
                                          15. Agarwal K et al: Slowly growing swelling on body of the mandible with paresthesia on lower lip. Oral Surg Oral Med Oral Pathol Oral Radiol. 114(6):677-82, 2012
                                          16. Kurup S et al: Intraoral schwannoma--a report of two cases. BMJ Case Rep. 2012, 2012
                                          17. Deichler J et al: Solitary intraosseous neurofibroma of the mandible. Apropos of a case. Med Oral Patol Oral Cir Bucal. 16(6):e704-7, 2011
                                          18. Chrcanovic BR et al: Neurofibromatosis type 1 associated with bilateral central giant cell granuloma of the mandible. J Craniomaxillofac Surg. 39(7):538-43, 2010
                                          19. Isildak H et al: Schwannoma of the hard palate. J Craniofac Surg. 21(1):276-8, 2010
                                          20. Tao Q et al: Neurofibroma in the left mandible: a case report. Kaohsiung J Med Sci. 26(4):217-21, 2010
                                          21. Vera-Sempere F et al: Intraosseus plexiform schwannoma of the mandible: immunohistochemical differential diagnosis. J Craniofac Surg. 21(6):1820-4, 2010
                                          22. Wasa J et al: MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74, 2010
                                          23. Woertler K: Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol. 14(5):547-58, 2010
                                          24. Yamaguchi R et al: Solitary intraosseous neurofibroma of the frontal bone. Case report. Neurol Med Chir (Tokyo). 50(8):683-6, 2010
                                          25. Buric N et al: Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol. 38(3):178-81, 2009
                                          26. Depprich R et al: Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case. Head Face Med. 5:24, 2009
                                          27. Martins MD et al: Intra-oral schwannoma: case report and literature review. Indian J Dent Res. 20(1):121-5, 2009
                                          28. Salla JT et al: Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res. 23(1):43-8, 2009
                                          29. Subhashraj K et al: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal. 14(1):E12-4, 2009
                                          30. Chao JC et al: Malignant schwannoma of the mandible: a case report. Auris Nasus Larynx. 34(2):287-91, 2007
                                          31. de Lacerda SA et al: Intraosseous schwannoma of mandibular symphysis: case report. Braz Dent J. 17(3):255-8, 2006
                                          32. Pimkhaokham A et al: Central neurilemmoma of the jaw in concurrence with radicular cyst: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 102(4):e34-6, 2006
                                          33. Vivek N et al: Solitary intraosseous neurofibroma of mandible. Indian J Dent Res. 17(3):135-8, 2006
                                          34. Hisatomi M et al: Bone deformity showing a deep coronoid notch of the mandible in a patient with neurofibromatosis type 1. Dentomaxillofac Radiol. 34(6):380-3, 2005
                                          35. Amir R et al: Neurilemmoma of the hard palate. J Oral Maxillofac Surg. 60(9):1069-71, 2002
                                          36. Bekisz O et al: Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report. J Clin Periodontol. 27(5):361-5, 2000
                                          37. Sadeghi EM et al: Intrabony neurilemmoma: diagnosis and management. J Am Dent Assoc. 129(6):729-32, 1998
                                          38. Belli E et al: Schwannoma of the mandible. J Craniofac Surg. 8(5):413-6, 1997
                                          39. Habal MB: Malignant epithelioid schwannoma of the mandible and the skull base. J Craniofac Surg. 8(5):417-21, 1997
                                          40. Lee L et al: Radiographic features of the mandible in neurofibromatosis: a report of 10 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 81(3):361-7, 1996
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Synonyms

                                                        • Schwannoma: Neurilemmoma, peripheral fibroblastoma, neurinoma
                                                        • Neurofibroma (NF): Neurinoma
                                                      • Definitions

                                                        • Benign perineural tumor arising from cells of neural sheath
                                                          • Schwannoma: Arises from Schwann cells and displaces axons
                                                            • Schwann cells cover myelinated nerves
                                                          • NF: Mixture of Schwann cells and perineural cells that incorporate axons
                                                        • Malignant peripheral nerve sheath tumor
                                                          • Most commonly involves major nerve trunks, including brachial plexus

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Majumdar S et al: Malignant peripheral nerve sheath tumor -a rare malignancy in mandible. J Clin Diagn Res. 10(6):ZD12-3, 2016
                                                                                  2. Noonan V et al: Enlargement of the inferior alveolar canal. J Mass Dent Soc. 64(4):37, 2016
                                                                                  3. Meundi MA et al: Intraosseous schwannoma of the maxilla mimicking a periapical lesion: a diagnostic challenge. J Clin Diagn Res. 9(3):ZD01-4, 2015
                                                                                  4. Patel S et al: Malignant peripheral nerve sheath tumour (MPNST) of mandible: solving the perplexity. BMJ Case Rep. 2015, 2015
                                                                                  5. Yin Y et al: Microcystic/reticular schwannoma of the mandible first case report and review of the literature. Medicine (Baltimore). 94(45):e1974, 2015
                                                                                  6. Aboh IV et al: Giant palatal schwannoma. J Craniofac Surg. 25(5):e418-20, 2014
                                                                                  7. Jain D et al: Neurofibroma of the maxillary antrum: a rare case. Contemp Clin Dent. 5(1):115-8, 2014
                                                                                  8. Jangam SS et al: Solitary intraosseous neurofibroma: report of a unique case. Contemp Clin Dent. 5(4):561-3, 2014
                                                                                  9. Naina P et al: Infraorbital nerve schwannoma: a rare cause of upper jaw swelling. Indian J Dent Res. 25(2):263-5, 2014
                                                                                  10. Bodner L et al: [Introsseous schwannoma of the mandible.] Fogorv Sz. 106(4):131-4, 2013
                                                                                  11. da Rosa MR et al: Solitary giant neurofibroma of the mental nerve: a trauma-related lesion? J Craniofac Surg. 24(3):e247-51, 2013
                                                                                  12. Lambade PN et al: Unusual intramaxillary plexiform schwannoma. Oral Maxillofac Surg. 17(2):137-40, 2013
                                                                                  13. Suga K et al: Intraosseous schwannoma originating in inferior alveolar nerve: a case report. Bull Tokyo Dent Coll. 54(1):19-25, 2013
                                                                                  14. Vuity D et al: [A 40 year old palatal neurofibroma. A case report.] Fogorv Sz. 106(1):3-6, 2013
                                                                                  15. Agarwal K et al: Slowly growing swelling on body of the mandible with paresthesia on lower lip. Oral Surg Oral Med Oral Pathol Oral Radiol. 114(6):677-82, 2012
                                                                                  16. Kurup S et al: Intraoral schwannoma--a report of two cases. BMJ Case Rep. 2012, 2012
                                                                                  17. Deichler J et al: Solitary intraosseous neurofibroma of the mandible. Apropos of a case. Med Oral Patol Oral Cir Bucal. 16(6):e704-7, 2011
                                                                                  18. Chrcanovic BR et al: Neurofibromatosis type 1 associated with bilateral central giant cell granuloma of the mandible. J Craniomaxillofac Surg. 39(7):538-43, 2010
                                                                                  19. Isildak H et al: Schwannoma of the hard palate. J Craniofac Surg. 21(1):276-8, 2010
                                                                                  20. Tao Q et al: Neurofibroma in the left mandible: a case report. Kaohsiung J Med Sci. 26(4):217-21, 2010
                                                                                  21. Vera-Sempere F et al: Intraosseus plexiform schwannoma of the mandible: immunohistochemical differential diagnosis. J Craniofac Surg. 21(6):1820-4, 2010
                                                                                  22. Wasa J et al: MRI features in the differentiation of malignant peripheral nerve sheath tumors and neurofibromas. AJR Am J Roentgenol. 194(6):1568-74, 2010
                                                                                  23. Woertler K: Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol. 14(5):547-58, 2010
                                                                                  24. Yamaguchi R et al: Solitary intraosseous neurofibroma of the frontal bone. Case report. Neurol Med Chir (Tokyo). 50(8):683-6, 2010
                                                                                  25. Buric N et al: Mandible schwannoma (neurilemmoma) presenting as periapical lesion. Dentomaxillofac Radiol. 38(3):178-81, 2009
                                                                                  26. Depprich R et al: Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case. Head Face Med. 5:24, 2009
                                                                                  27. Martins MD et al: Intra-oral schwannoma: case report and literature review. Indian J Dent Res. 20(1):121-5, 2009
                                                                                  28. Salla JT et al: Retrospective analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res. 23(1):43-8, 2009
                                                                                  29. Subhashraj K et al: Ancient schwannoma arising from mental nerve. A case report and review. Med Oral Patol Oral Cir Bucal. 14(1):E12-4, 2009
                                                                                  30. Chao JC et al: Malignant schwannoma of the mandible: a case report. Auris Nasus Larynx. 34(2):287-91, 2007
                                                                                  31. de Lacerda SA et al: Intraosseous schwannoma of mandibular symphysis: case report. Braz Dent J. 17(3):255-8, 2006
                                                                                  32. Pimkhaokham A et al: Central neurilemmoma of the jaw in concurrence with radicular cyst: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 102(4):e34-6, 2006
                                                                                  33. Vivek N et al: Solitary intraosseous neurofibroma of mandible. Indian J Dent Res. 17(3):135-8, 2006
                                                                                  34. Hisatomi M et al: Bone deformity showing a deep coronoid notch of the mandible in a patient with neurofibromatosis type 1. Dentomaxillofac Radiol. 34(6):380-3, 2005
                                                                                  35. Amir R et al: Neurilemmoma of the hard palate. J Oral Maxillofac Surg. 60(9):1069-71, 2002
                                                                                  36. Bekisz O et al: Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report. J Clin Periodontol. 27(5):361-5, 2000
                                                                                  37. Sadeghi EM et al: Intrabony neurilemmoma: diagnosis and management. J Am Dent Assoc. 129(6):729-32, 1998
                                                                                  38. Belli E et al: Schwannoma of the mandible. J Craniofac Surg. 8(5):413-6, 1997
                                                                                  39. Habal MB: Malignant epithelioid schwannoma of the mandible and the skull base. J Craniofac Surg. 8(5):417-21, 1997
                                                                                  40. Lee L et al: Radiographic features of the mandible in neurofibromatosis: a report of 10 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 81(3):361-7, 1996