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Mandible-Maxilla Non-Hodgkin Lymphoma
Christine M. Glastonbury, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Non-Hodgkin lymphoma (NHL)
            • Definitions

              • Lymphoma is lymphoreticular system malignancy
              • All lymphomas designated Hodgkin (HL) or non-Hodgkin (NHL)
                • HL: Neoplastic Reed-Sternberg cells with mixed inflammatory cell mass
                • NHL: Multiple subtypes of B-cell, T-cell, or NK-cell lymphomas/leukemias
                  • Diffuse large B cell (DLBCL) most common (30%)
              • Head & neck NHL has multiple forms
                • Nodal, non-nodal lymphatic (tonsils & adenoids), extralymphatic (e.g., thyroid, sinuses)

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Edge SB et al: Lymphoid Neoplasms. 7th ed. AJCC Cancer Staging Manual. New York: Springer. 599-615, 2010
                                      2. Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010
                                      3. Weiler-Sagie M et al: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 51(1):25-30, 2010
                                      4. Gaini RM et al: Lymphomas of head and neck in pediatric patients. Int J Pediatr Otorhinolaryngol. 73 Suppl 1:S65-70, 2009
                                      5. Abramson SJ et al: Imaging of pediatric lymphomas. Radiol Clin North Am. 46(2):313-38, ix, 2008
                                      6. Cheson BD: New staging and response criteria for non-Hodgkin lymphoma and Hodgkin lymphoma. Radiol Clin North Am. 46(2):213-23, vii, 2008
                                      7. Haque S et al: Imaging of lymphoma of the central nervous system, spine, and orbit. Radiol Clin North Am. 46(2):339-61, ix, 2008
                                      8. Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
                                      9. Swerdlow SH et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: IARC Press. 158-66, 2008
                                      10. Armitage JO: Staging non-Hodgkin lymphoma. CA Cancer J Clin. 55(6):368-76, 2005
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Non-Hodgkin lymphoma (NHL)
                                                • Definitions

                                                  • Lymphoma is lymphoreticular system malignancy
                                                  • All lymphomas designated Hodgkin (HL) or non-Hodgkin (NHL)
                                                    • HL: Neoplastic Reed-Sternberg cells with mixed inflammatory cell mass
                                                    • NHL: Multiple subtypes of B-cell, T-cell, or NK-cell lymphomas/leukemias
                                                      • Diffuse large B cell (DLBCL) most common (30%)
                                                  • Head & neck NHL has multiple forms
                                                    • Nodal, non-nodal lymphatic (tonsils & adenoids), extralymphatic (e.g., thyroid, sinuses)

                                                IMAGING

                                                • General Features

                                                  • CT Findings

                                                    • MR Findings

                                                      • Nuclear Medicine Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Edge SB et al: Lymphoid Neoplasms. 7th ed. AJCC Cancer Staging Manual. New York: Springer. 599-615, 2010
                                                                          2. Paes FM et al: FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics. 30(1):269-91, 2010
                                                                          3. Weiler-Sagie M et al: (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 51(1):25-30, 2010
                                                                          4. Gaini RM et al: Lymphomas of head and neck in pediatric patients. Int J Pediatr Otorhinolaryngol. 73 Suppl 1:S65-70, 2009
                                                                          5. Abramson SJ et al: Imaging of pediatric lymphomas. Radiol Clin North Am. 46(2):313-38, ix, 2008
                                                                          6. Cheson BD: New staging and response criteria for non-Hodgkin lymphoma and Hodgkin lymphoma. Radiol Clin North Am. 46(2):213-23, vii, 2008
                                                                          7. Haque S et al: Imaging of lymphoma of the central nervous system, spine, and orbit. Radiol Clin North Am. 46(2):339-61, ix, 2008
                                                                          8. Matasar MJ et al: Overview of lymphoma diagnosis and management. Radiol Clin North Am. 46(2):175-98, vii, 2008
                                                                          9. Swerdlow SH et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: IARC Press. 158-66, 2008
                                                                          10. Armitage JO: Staging non-Hodgkin lymphoma. CA Cancer J Clin. 55(6):368-76, 2005