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Mandible-Maxilla Paget Disease
C. Grace Petrikowski, DDS, MSc, FRCD(C)
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Paget disease (PD)
            • Synonyms

              • Osteitis deformans
            • Definitions

              • Chronic disease of osteoclasts: Disordered and excessive bone remodeling resulting from alternating waves of osteoclastic and osteoblastic activity
                • Active and quiescent phases
                • Anatomic distribution asymmetric and not all bones may be involved
              • Individual sites progress at variable rates; differing phases may be seen within same patient

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      • Nuclear Medicine Findings

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Al-Rashid M et al: Paget disease of bone. Orthop Clin North Am. 46(4):577-85, 2015
                                              2. Griz L et al: Diagnosis and management of Paget's disease of bone. Arq Bras Endocrinol Metabol. 58(6):587-99, 2014
                                              3. Bolland MJ et al: Paget's disease of bone: clinical review and update. J Clin Pathol. 66(11):924-7, 2013
                                              4. Wat WZ et al: A case series of Paget's disease of bone in Chinese. Hong Kong Med J. 19(3):242-8, 2013
                                              5. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                              6. Roodman GD et al: Paget disease of bone. J Clin Invest. 115(2):200-8, 2005
                                              7. Hullar TE et al: Paget's disease and fibrous dysplasia. Otolaryngol Clin North Am. 36(4):707-32, 2003
                                              8. Whitten CR et al: MRI of Paget's disease of bone. Clin Radiol. 58(10):763-9, 2003
                                              9. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                              10. Ankrom MA et al: Paget's disease of bone (osteitis deformans). J Am Geriatr Soc. 46(8):1025-33, 1998
                                              11. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                              12. Tehranzadeh J et al: Computed tomography of Paget disease of the skull versus fibrous dysplasia. Skeletal Radiol. 27(12):664-72, 1998
                                              13. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                              14. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                              15. Carrillo R et al: Benign fibro-osseous lesions in Paget's disease of the jaws. Oral Surg Oral Med Oral Pathol. 71(5):588-92, 1991
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Paget disease (PD)
                                                        • Synonyms

                                                          • Osteitis deformans
                                                        • Definitions

                                                          • Chronic disease of osteoclasts: Disordered and excessive bone remodeling resulting from alternating waves of osteoclastic and osteoblastic activity
                                                            • Active and quiescent phases
                                                            • Anatomic distribution asymmetric and not all bones may be involved
                                                          • Individual sites progress at variable rates; differing phases may be seen within same patient

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • MR Findings

                                                                • Imaging Recommendations

                                                                  • Nuclear Medicine Findings

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Al-Rashid M et al: Paget disease of bone. Orthop Clin North Am. 46(4):577-85, 2015
                                                                                          2. Griz L et al: Diagnosis and management of Paget's disease of bone. Arq Bras Endocrinol Metabol. 58(6):587-99, 2014
                                                                                          3. Bolland MJ et al: Paget's disease of bone: clinical review and update. J Clin Pathol. 66(11):924-7, 2013
                                                                                          4. Wat WZ et al: A case series of Paget's disease of bone in Chinese. Hong Kong Med J. 19(3):242-8, 2013
                                                                                          5. Hansen MF et al: Osteosarcoma in Paget's disease of bone. J Bone Miner Res. 21 Suppl 2:P58-63, 2006
                                                                                          6. Roodman GD et al: Paget disease of bone. J Clin Invest. 115(2):200-8, 2005
                                                                                          7. Hullar TE et al: Paget's disease and fibrous dysplasia. Otolaryngol Clin North Am. 36(4):707-32, 2003
                                                                                          8. Whitten CR et al: MRI of Paget's disease of bone. Clin Radiol. 58(10):763-9, 2003
                                                                                          9. Smith SE et al: From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 22(5):1191-216, 2002
                                                                                          10. Ankrom MA et al: Paget's disease of bone (osteitis deformans). J Am Geriatr Soc. 46(8):1025-33, 1998
                                                                                          11. Boutin RD et al: Complications in Paget disease at MR imaging. Radiology. 209(3):641-51, 1998
                                                                                          12. Tehranzadeh J et al: Computed tomography of Paget disease of the skull versus fibrous dysplasia. Skeletal Radiol. 27(12):664-72, 1998
                                                                                          13. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part I. Skeletal Radiol. 24(3):163-71, 1995
                                                                                          14. Mirra JM et al: Paget's disease of bone: review with emphasis on radiologic features, Part II. Skeletal Radiol. 24(3):173-84, 1995
                                                                                          15. Carrillo R et al: Benign fibro-osseous lesions in Paget's disease of the jaws. Oral Surg Oral Med Oral Pathol. 71(5):588-92, 1991