Rare malignancy arising from odontogenic epithelium residues in bone
Arises de novo from intraosseous remnants of odontogenic epithelium: Rests of Malassez, remnants of dental lamina, or reduced enamel epithelium surrounding unerupted/impacted tooth
Covered by normal mucosa; no cystic component or other odontogenic tumor cells; absence of primary tumor elsewhere (not metastatic)
Does not include osseous spread from soft tissue carcinoma (gingiva, alveolar ridge, floor of mouth)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Geetha P et al: Primary intraosseous carcinoma of the mandible: a clinicoradiographic view. J Cancer Res Ther. 11(3):651, 2015
Lukandu OM et al: Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(5):e204-9, 2015
Sukegawa S et al: Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report. Oncol Lett. 9(1):131-135, 2015
Iino M et al: Solid type primary intraosseous squamous cell carcinoma in the maxilla: report of a new case. BMC Ear Nose Throat Disord. 13(1):13, 2013
Tamgadge S et al: Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review. Ecancermedicalscience. 7:316, 2013
Choi YJ et al: Primary intraosseous squamous cell carcinoma mimicking periapical disease: a case report. Imaging Sci Dent. 42(4):265-70, 2012
Huang JW et al: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med. 133(11):1834-40, 2009
Lin YJ et al: Primary intraosseous carcinoma of the mandible. Dentomaxillofac Radiol. 34(2):112-6, 2005
Thomas G et al: Primary intraosseous carcinoma of the mandible--a case report and review of the literature. Eur J Surg Oncol. 26(1):82-6, 2000
Kaffe I et al: Radiological features of primary intra-osseous carcinoma of the jaws. Analysis of the literature and report of a new case. Dentomaxillofac Radiol. 27(4):209-14, 1998
Ariji E et al: Central squamous cell carcinoma of the mandible. Computed tomographic findings. Oral Surg Oral Med Oral Pathol. 77(5):541-8, 1994
Elzay RP: Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 54(3):299-303, 1982
Rare malignancy arising from odontogenic epithelium residues in bone
Arises de novo from intraosseous remnants of odontogenic epithelium: Rests of Malassez, remnants of dental lamina, or reduced enamel epithelium surrounding unerupted/impacted tooth
Covered by normal mucosa; no cystic component or other odontogenic tumor cells; absence of primary tumor elsewhere (not metastatic)
Does not include osseous spread from soft tissue carcinoma (gingiva, alveolar ridge, floor of mouth)
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Geetha P et al: Primary intraosseous carcinoma of the mandible: a clinicoradiographic view. J Cancer Res Ther. 11(3):651, 2015
Lukandu OM et al: Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(5):e204-9, 2015
Sukegawa S et al: Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report. Oncol Lett. 9(1):131-135, 2015
Iino M et al: Solid type primary intraosseous squamous cell carcinoma in the maxilla: report of a new case. BMC Ear Nose Throat Disord. 13(1):13, 2013
Tamgadge S et al: Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review. Ecancermedicalscience. 7:316, 2013
Choi YJ et al: Primary intraosseous squamous cell carcinoma mimicking periapical disease: a case report. Imaging Sci Dent. 42(4):265-70, 2012
Huang JW et al: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med. 133(11):1834-40, 2009
Lin YJ et al: Primary intraosseous carcinoma of the mandible. Dentomaxillofac Radiol. 34(2):112-6, 2005
Thomas G et al: Primary intraosseous carcinoma of the mandible--a case report and review of the literature. Eur J Surg Oncol. 26(1):82-6, 2000
Kaffe I et al: Radiological features of primary intra-osseous carcinoma of the jaws. Analysis of the literature and report of a new case. Dentomaxillofac Radiol. 27(4):209-14, 1998
Ariji E et al: Central squamous cell carcinoma of the mandible. Computed tomographic findings. Oral Surg Oral Med Oral Pathol. 77(5):541-8, 1994
Elzay RP: Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 54(3):299-303, 1982
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