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Mandible-Maxilla Primary Intraosseous Squamous Cell Carcinoma
C. Grace Petrikowski, DDS, MSc, FRCD(C)
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Primary intraosseous squamous cell carcinoma (PIOSCC)
            • Synonyms

              • Central squamous cell carcinoma, primary intraosseous carcinoma, odontogenic squamous cell carcinoma, primary intraalveolar carcinoma, primary odontogenic carcinoma
            • Definitions

              • Rare malignancy arising from odontogenic epithelium residues in bone
                • Arises de novo from intraosseous remnants of odontogenic epithelium: Rests of Malassez, remnants of dental lamina, or reduced enamel epithelium surrounding unerupted/impacted tooth
                • Covered by normal mucosa; no cystic component or other odontogenic tumor cells; absence of primary tumor elsewhere (not metastatic)
                • Does not include osseous spread from soft tissue carcinoma (gingiva, alveolar ridge, floor of mouth)

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • Staging, Grading, & Classification

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Geetha P et al: Primary intraosseous carcinoma of the mandible: a clinicoradiographic view. J Cancer Res Ther. 11(3):651, 2015
                                      2. Lukandu OM et al: Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(5):e204-9, 2015
                                      3. Sukegawa S et al: Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report. Oncol Lett. 9(1):131-135, 2015
                                      4. Iino M et al: Solid type primary intraosseous squamous cell carcinoma in the maxilla: report of a new case. BMC Ear Nose Throat Disord. 13(1):13, 2013
                                      5. Tamgadge S et al: Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review. Ecancermedicalscience. 7:316, 2013
                                      6. Choi YJ et al: Primary intraosseous squamous cell carcinoma mimicking periapical disease: a case report. Imaging Sci Dent. 42(4):265-70, 2012
                                      7. Huang JW et al: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med. 133(11):1834-40, 2009
                                      8. Lin YJ et al: Primary intraosseous carcinoma of the mandible. Dentomaxillofac Radiol. 34(2):112-6, 2005
                                      9. Thomas G et al: Primary intraosseous carcinoma of the mandible--a case report and review of the literature. Eur J Surg Oncol. 26(1):82-6, 2000
                                      10. Kaffe I et al: Radiological features of primary intra-osseous carcinoma of the jaws. Analysis of the literature and report of a new case. Dentomaxillofac Radiol. 27(4):209-14, 1998
                                      11. Ariji E et al: Central squamous cell carcinoma of the mandible. Computed tomographic findings. Oral Surg Oral Med Oral Pathol. 77(5):541-8, 1994
                                      12. Elzay RP: Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 54(3):299-303, 1982
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • Primary intraosseous squamous cell carcinoma (PIOSCC)
                                                • Synonyms

                                                  • Central squamous cell carcinoma, primary intraosseous carcinoma, odontogenic squamous cell carcinoma, primary intraalveolar carcinoma, primary odontogenic carcinoma
                                                • Definitions

                                                  • Rare malignancy arising from odontogenic epithelium residues in bone
                                                    • Arises de novo from intraosseous remnants of odontogenic epithelium: Rests of Malassez, remnants of dental lamina, or reduced enamel epithelium surrounding unerupted/impacted tooth
                                                    • Covered by normal mucosa; no cystic component or other odontogenic tumor cells; absence of primary tumor elsewhere (not metastatic)
                                                    • Does not include osseous spread from soft tissue carcinoma (gingiva, alveolar ridge, floor of mouth)

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • Staging, Grading, & Classification

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Geetha P et al: Primary intraosseous carcinoma of the mandible: a clinicoradiographic view. J Cancer Res Ther. 11(3):651, 2015
                                                                          2. Lukandu OM et al: Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(5):e204-9, 2015
                                                                          3. Sukegawa S et al: Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report. Oncol Lett. 9(1):131-135, 2015
                                                                          4. Iino M et al: Solid type primary intraosseous squamous cell carcinoma in the maxilla: report of a new case. BMC Ear Nose Throat Disord. 13(1):13, 2013
                                                                          5. Tamgadge S et al: Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: a case report and literature review. Ecancermedicalscience. 7:316, 2013
                                                                          6. Choi YJ et al: Primary intraosseous squamous cell carcinoma mimicking periapical disease: a case report. Imaging Sci Dent. 42(4):265-70, 2012
                                                                          7. Huang JW et al: Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med. 133(11):1834-40, 2009
                                                                          8. Lin YJ et al: Primary intraosseous carcinoma of the mandible. Dentomaxillofac Radiol. 34(2):112-6, 2005
                                                                          9. Thomas G et al: Primary intraosseous carcinoma of the mandible--a case report and review of the literature. Eur J Surg Oncol. 26(1):82-6, 2000
                                                                          10. Kaffe I et al: Radiological features of primary intra-osseous carcinoma of the jaws. Analysis of the literature and report of a new case. Dentomaxillofac Radiol. 27(4):209-14, 1998
                                                                          11. Ariji E et al: Central squamous cell carcinoma of the mandible. Computed tomographic findings. Oral Surg Oral Med Oral Pathol. 77(5):541-8, 1994
                                                                          12. Elzay RP: Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 54(3):299-303, 1982