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Marrow Distribution: Normal
Sandra Moore, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Synonyms

          • Marrow distribution: Normal developmental conversion of red to yellow marrow
        • Definitions

          • Hematopoietic (red) and fatty (yellow) marrow coexist within medullary space
            • Relationship is dynamic
            • Changes throughout development in orderly fashion
            • Detectable as changes in SI on routine MR sequences

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Imaging Recommendations

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • Staging, Grading, & Classification

                    • Gross Pathologic & Surgical Features

                      DIAGNOSTIC CHECKLIST

                      • Consider

                        • Image Interpretation Pearls

                          • Reporting Tips

                            Selected References

                            1. Kohl CA et al: Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis: review of a single institution's experience. Skeletal Radiol. 43(8):1079-84, 2014
                            2. Chen BB et al: Dynamic contrast-enhanced MR imaging measurement of vertebral bone marrow perfusion may be indicator of outcome of acute myeloid leukemia patients in remission. Radiology. 258(3):821-31, 2011
                            3. Kung JW et al: Bone marrow signal alteration in the extremities. AJR Am J Roentgenol. 196(5):W492-510, 2011
                            4. Laor T et al: MR imaging insights into skeletal maturation: what is normal? Radiology. 250(1):28-38, 2009
                            5. Shabshin N et al: Age dependent T2 changes of bone marrow in pediatric wrist MRI. Skeletal Radiol. 38(12):1163-8, 2009
                            6. Van der Woude HJ et al: Contrast-enhanced magnetic resonance imaging of bone marrow. Semin Musculoskelet Radiol. 5(1):21-33, 2001
                            7. Ricci C et al: Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology. 177(1):83-8, 1990
                            8. Custer RP: An Atlas of the Blood and Bone Marrow. Philadelphia: Saunders, 1974
                            9. Ellis RE: The distribution of active bone marrow in the adult. Phys Med Biol. 5:255-8, 1961
                            Related Anatomy
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                            Related Differential Diagnoses
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                            References
                            Tables

                            Tables

                            KEY FACTS

                            • Terminology

                              • Imaging

                                • Diagnostic Checklist

                                  TERMINOLOGY

                                  • Synonyms

                                    • Marrow distribution: Normal developmental conversion of red to yellow marrow
                                  • Definitions

                                    • Hematopoietic (red) and fatty (yellow) marrow coexist within medullary space
                                      • Relationship is dynamic
                                      • Changes throughout development in orderly fashion
                                      • Detectable as changes in SI on routine MR sequences

                                  IMAGING

                                  • General Features

                                    • CT Findings

                                      • MR Findings

                                        • Imaging Recommendations

                                          DIFFERENTIAL DIAGNOSIS

                                            PATHOLOGY

                                            • Staging, Grading, & Classification

                                              • Gross Pathologic & Surgical Features

                                                DIAGNOSTIC CHECKLIST

                                                • Consider

                                                  • Image Interpretation Pearls

                                                    • Reporting Tips

                                                      Selected References

                                                      1. Kohl CA et al: Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis: review of a single institution's experience. Skeletal Radiol. 43(8):1079-84, 2014
                                                      2. Chen BB et al: Dynamic contrast-enhanced MR imaging measurement of vertebral bone marrow perfusion may be indicator of outcome of acute myeloid leukemia patients in remission. Radiology. 258(3):821-31, 2011
                                                      3. Kung JW et al: Bone marrow signal alteration in the extremities. AJR Am J Roentgenol. 196(5):W492-510, 2011
                                                      4. Laor T et al: MR imaging insights into skeletal maturation: what is normal? Radiology. 250(1):28-38, 2009
                                                      5. Shabshin N et al: Age dependent T2 changes of bone marrow in pediatric wrist MRI. Skeletal Radiol. 38(12):1163-8, 2009
                                                      6. Van der Woude HJ et al: Contrast-enhanced magnetic resonance imaging of bone marrow. Semin Musculoskelet Radiol. 5(1):21-33, 2001
                                                      7. Ricci C et al: Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology. 177(1):83-8, 1990
                                                      8. Custer RP: An Atlas of the Blood and Bone Marrow. Philadelphia: Saunders, 1974
                                                      9. Ellis RE: The distribution of active bone marrow in the adult. Phys Med Biol. 5:255-8, 1961