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Mastocytosis
Michael P. Federle, MD, FACR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Systemic mastocytosis (SM)
          • Synonyms

            • Systemic mast cell disease
          • Definitions

            • Rare disorder characterized by mast cell proliferation in skin, bones, lymph nodes, and abdominal viscera

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • Nuclear Medicine Findings

                  DIFFERENTIAL DIAGNOSIS

                    PATHOLOGY

                    • General Features

                      • Staging, Grading, & Classification

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Bonadonna P et al: Mastocytosis and allergic diseases. J Investig Allergol Clin Immunol. 24(5):288-97; quiz 3 p preceding 297, 2014
                                    2. Ustun C et al: Hematopoietic stem-cell transplantation for advanced systemic mastocytosis. J Clin Oncol. 32(29):3264-74, 2014
                                    3. Black JS et al: Systemic mastocytosis as a rare cause of diffuse gastrointestinal hemorrhage. Am Surg. 75(5):429-30, 2009
                                    4. Butterfield JH: Survey of aspirin administration in systemic mastocytosis. Prostaglandins Other Lipid Mediat. 88(3-4):122-4, 2009
                                    5. Lim KH et al: Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 113(23):5727-36, 2009
                                    6. Vannucchi AM et al: Advances in understanding and management of myeloproliferative neoplasms. CA Cancer J Clin. 59(3):171-91, 2009
                                    7. Avila NA et al: Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 202(2):367-72, 1997
                                    8. Metcalfe DD: The liver, spleen, and lymph nodes in mastocytosis. J Invest Dermatol. 96(3):45S-46S, 1991
                                    9. Johnson AC et al: Systemic mastocytosis and mastocytosis-like syndrome: radiologic features of gastrointestinal manifestations. South Med J. 81(6):729-33, 750, 1988
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Imaging

                                      • Top Differential Diagnoses

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Systemic mastocytosis (SM)
                                            • Synonyms

                                              • Systemic mast cell disease
                                            • Definitions

                                              • Rare disorder characterized by mast cell proliferation in skin, bones, lymph nodes, and abdominal viscera

                                            IMAGING

                                            • General Features

                                              • Radiographic Findings

                                                • CT Findings

                                                  • Nuclear Medicine Findings

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Staging, Grading, & Classification

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Bonadonna P et al: Mastocytosis and allergic diseases. J Investig Allergol Clin Immunol. 24(5):288-97; quiz 3 p preceding 297, 2014
                                                                      2. Ustun C et al: Hematopoietic stem-cell transplantation for advanced systemic mastocytosis. J Clin Oncol. 32(29):3264-74, 2014
                                                                      3. Black JS et al: Systemic mastocytosis as a rare cause of diffuse gastrointestinal hemorrhage. Am Surg. 75(5):429-30, 2009
                                                                      4. Butterfield JH: Survey of aspirin administration in systemic mastocytosis. Prostaglandins Other Lipid Mediat. 88(3-4):122-4, 2009
                                                                      5. Lim KH et al: Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 113(23):5727-36, 2009
                                                                      6. Vannucchi AM et al: Advances in understanding and management of myeloproliferative neoplasms. CA Cancer J Clin. 59(3):171-91, 2009
                                                                      7. Avila NA et al: Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 202(2):367-72, 1997
                                                                      8. Metcalfe DD: The liver, spleen, and lymph nodes in mastocytosis. J Invest Dermatol. 96(3):45S-46S, 1991
                                                                      9. Johnson AC et al: Systemic mastocytosis and mastocytosis-like syndrome: radiologic features of gastrointestinal manifestations. South Med J. 81(6):729-33, 750, 1988